Search Results - "KLEIN, Wolfram"

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants by Glas, Jürgen, Seiderer, Julia, Wetzke, Martin, Konrad, Astrid, Török, Helga-Paula, Schmechel, Silke, Tonenchi, Laurian, Grassl, Christine, Dambacher, Julia, Pfennig, Simone, Maier, Kerstin, Griga, Thomas, Klein, Wolfram, Epplen, Jörg T, Schiemann, Uwe, Folwaczny, Christian, Lohse, Peter, Göke, Burkhard, Ochsenkühn, Thomas, Müller-Myhsok, Bertram, Folwaczny, Matthias, Mussack, Thomas, Brand, Stephan

“…The IL23R gene has been identified as a susceptibility gene for inflammatory bowel disease (IBD) in the North American population. The aim of our study was to…”
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Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset by Glas, Jürgen, Seiderer, Julia, Nagy, Melinda, Fries, Christoph, Beigel, Florian, Weidinger, Maria, Pfennig, Simone, Klein, Wolfram, Epplen, Jörg T, Lohse, Peter, Folwaczny, Matthias, Göke, Burkhard, Ochsenkühn, Thomas, Diegelmann, Julia, Müller-Myhsok, Bertram, Roeske, Darina, Brand, Stephan

“…Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple…”
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Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease by Török, Helga P, Glas, Jürgen, Endres, Ilona, Tonenchi, Laurian, Teshome, Molla Y, Wetzke, Martin, Klein, Wolfram, Lohse, Peter, Ochsenkühn, Thomas, Folwaczny, Matthias, Göke, Burkhard, Folwaczny, Christian, Müller-Myhsok, Bertram, Brand, Stephan

“…Recent data suggest functional interactions between NOD2 and other receptors of the innate immune system modulating inflammatory responses. Here we analyzed…”
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The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease by Glas, Jürgen, Török, Helga-Paula, Tonenchi, Laurian, Wetzke, Martin, Beynon, Vanessa, Teshome, Molla Y., Cotofana, Sebastian, Schiemann, Uwe, Griga, Thomas, Klein, Wolfram, Epplen, Joerg T., Folwaczny, Christian, Folwaczny, Matthias, Mussack, Thomas, Weiss, Elisabeth H.

“…HLA-G is a non-classical MHC class Ib molecule predominantly expressed in cytotrophoblasts and under pathological conditions also in chronically inflamed and…”
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Bi-allelic loss-of-function variants in KIF21A cause severe fetal akinesia with arthrogryposis multiplex by Falb, Ruth J, Müller, Amelie J, Klein, Wolfram, Grimmel, Mona, Grasshoff, Ute, Spranger, Stephanie, Stöbe, Petra, Gauck, Darja, Kuechler, Alma, Dikow, Nicola, Schwaibold, Eva M C, Schmidt, Christoph, Averdunk, Luisa, Buchert, Rebecca, Heinrich, Tilman, Prodan, Natalia, Park, Joohyun, Kehrer, Martin, Sturm, Marc, Kelemen, Olga, Hartmann, Silke, Horn, Denise, Emmerich, Dirk, Hirt, Nina, Neumann, Armin, Kristiansen, Glen, Gembruch, Ulrich, Haen, Susanne, Siebert, Reiner, Hentze, Sabine, Hoopmann, Markus, Ossowski, Stephan, Waldmüller, Stephan, Beck-Wödl, Stefanie, Gläser, Dieter, Tekesin, Ismail, Distelmaier, Felix, Riess, Olaf, Kagan, Karl-Oliver, Dufke, Andreas, Haack, Tobias B

“…Fetal akinesia (FA) results in variable clinical presentations and has been associated with more than 166 different disease loci. However, the underlying…”
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Evaluation of the aromaticity of borepin: synthesis and properties of 1-substituted borepins by Ashe, Arthur J, Klein, Wolfram, Rousseau, Roger

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Simulation-Based Robust Scheduling for Smart Factories Considering Improved Test Strategies by Hipp, Ulrich, Zeh, Tobias, Klein, Wolfram, Joanni, Andreas, Rothbauer, Stefan, Zeller, Marc

“…Summary & ConclusionsIn the context of Industrie 4.0, the vision of an adaptable and flexible factory is addressed, and therefore the ability of a factory to…”
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Complex genetic predisposition in adult and juvenile rheumatoid arthritis by Miterski, Bianca, Drynda, Susanne, Böschow, Gundula, Klein, Wolfram, Oppermann, Joachim, Kekow, Jörn, Epplen, Jörg Thomas

“…Rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) are complex multifactorial diseases caused by environmental influences and an unknown number…”
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Novel Genetic Risk Markers for Ulcerative Colitis in the IL2/IL21 Region Are in Epistasis With IL23R and Suggest a Common Genetic Background for Ulcerative Colitis and Celiac Disease by GLAS, Jiirgen, STALLHOFER, Johannes, KOLETZKO, Sibylle, FOLWACZNY, Matthias, LOHSE, Peter, GÖKE, Burkhard, OCHSENKÜHN, Thomas, MÜLLER-MYHSOK, Bertram, BRAND, Stephan, RIPKE, Stephan, WETZKE, Martin, PFENNIG, Simone, KLEIN, Wolfram, EPPLEN, Jörg T, GRIGA, Thomas, SCHIEMANN, Uwe, LACHER, Martin

“…Recently, a genome-wide association study showed that single-nucleotide polymorphisms (SNPs) in the chromosome 4q27 region containing IL2 and IL21 are…”
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The ATG16L1 Gene Variants rs2241879 and rs2241880 (T300A) Are Strongly Associated With Susceptibility to Crohn's Disease in the German Population by GLAS, Jürgen, KONRAD, Astrid, PFENNIG, Simone, HALLER, Dirk, GRIGA, Thomas, KLEIN, Wolfram, EPPLEN, Jörg T, FOLWACZNY, Christian, LOHSE, Peter, GÖKE, Burkhard, OCHSENKÜHN, Thomas, MUSSACK, Thomas, SCHMECHEL, Silke, FOLWACZNY, Matthias, MÜLLER-MYHSOK, Bertram, BRAND, Stephan, DAMBACHER, Julia, SEIDERER, Julia, SCHROFF, Frieder, WETZKE, Martin, ROESKE, Darina, TÖRÖK, Helga-Paula, TONENCHI, Laurian

“…We analyzed ATG16L1, a recently identified Crohn's disease (CD) susceptibility gene, in a large cohort with inflammatory bowel disease (IBD) including…”
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Preparation of polyfunctional olefins and allenes using 1,1-bimetallics of zinc and zirconium by Tucker, Charles E, Greve, Bjoern, Klein, Wolfram, Knochel, Paul

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A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses by Griga, Thomas, Wilkens, Christian, Wirkus, Natascha, Epplen, Joerg, Schmiegel, Wolff, Klein, Wolfram

“…Macrophage migration inhibitory factor (MIF) is an important cytokine involved in the regulation of the innate immune system in IBD. Secreted MIF is able to…”
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Rs224136 on Chromosome 10q21.1 and Variants in PHOX2B, NCF4, and FAM92B Are Not Major Genetic Risk Factors for Susceptibility to Crohn's Disease in the German Population by GLAS, Jürgen, SEIDERER, Julia, STALLHOFER, Johannes, JÜRGENS, Matthias, GRIGA, Thomas, KLEIN, Wolfram, EPPLEN, Jörg T, SCHIEMANN, Uwe, MUSSACK, Thomas, LOHSE, Peter, GÖKE, Burkhard, OCHSENKÜHN, Thomas, PASCIUTO, Giulia, FOLWACZNY, Matthias, MÜLLER-MYHSOK, Bertram, BRAND, Stephan, TILLACK, Cornelia, DIEGELMANN, Julia, PFENNIG, Simone, KONRAD, Astrid, SCHMECHEL, Silke, WETZKE, Martin, TÖRÖK, Helga-Paula

“…Recently, a North American genome-wide association study identified three novel gene variants in PHOX2B, NCF4, and FAM92B as well as one single nucleotide…”
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Role of the NFKB1 −94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL‐1RN genes by Glas, Jürgen, Török, Helga‐Paula, Tonenchi, Laurian, Müller‐Myhsok, Bertram, Mussack, Thomas, Wetzke, Martin, Klein, Wolfram, Epplen, Joerg T., Griga, Thomas, Schiemann, Uwe, Lohse, Peter, Seiderer, Julia, Schnitzler, Fabian, Brand, Stephan, Ochsenkühn, Thomas, Folwaczny, Matthias, Folwaczny, Christian

“…Background: Recently, an association of the NFKB1 polymorphism −94ins/delATTG with ulcerative colitis (UC) has been reported. This 4‐bp insertion/deletion…”
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A polymorphism of the NFKBIA gene is associated with Crohn's disease patients lacking a predisposing allele of the CARD15 gene by KLEIN, Wolfram, TROMM, Andreas, FOLWACZNY, Christian, HAGEDORN, Michaela, DUERIG, Natascha, EPPLEN, Joerg T, SCHMIEGEL, Wolff H, GRIGA, Thomas

“…Nuclear factor kappa-B (NFkappaB) plays a crucial role in diseases associated with dysregulated immune response. NFkappaB inhibitor alpha downregulates the…”
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Epistasis Between Toll-Like Receptor-9 Polymorph isms and Variants in NOD2 and IL23R Modulates Susceptibility to Crohn's Disease by TÖRÖK, Helga P, GLAS, Jürgen, GÖKE, Burkhard, FOLWACZNY, Christian, MÜLLER-MYHSOK, Bertram, BRAND, Stephan, ENDRES, Ilona, TONENCHI, Laurian, TESHOME, Molla Y, WETZKE, Martin, KLEIN, Wolfram, LOHSE, Peter, OCHSENKÜHN, Thomas, FOLWACZNY, Matthias

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Association of the ASP299GLY TLR4 polymorphism with COPD by Rohde, Gernot, Klein, Wolfram, Arinir, Umut, Hagedorn, Michaela, Duerig, Natascha, T. Bauer, Torsten, Gillissen, Adrian, Schultze-Werninghaus, Gerhard, T. Epplen, Jörg

“…Bacterial infection and colonization plays an important role in COPD. The inflammatory response to these bacteria is mediated by Toll-like receptors. The…”
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Polymorphisms in the interleukin-8 gene in patients with chronic obstructive pulmonary disease by Arinir, Umut, Klein, Wolfram, Rohde, Gernot, Stemmler, Susanne, Epplen, Joerg T., Schultze-Werninghaus, Gerhard

“…Airway inflammation is the main pathophysiological feature of patients with chronic obstructive pulmonary disease (COPD). Interleukin‐8 (IL‐8) is a potent…”
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rs224136 on Chromosome 10q21.1 and Variants in PHOX2B, NCF4, and FAM92B Are Not Major Genetic Risk Factors for Susceptibility to Crohnʼs Disease in the German Population by Glas, Jürgen, Seiderer, Julia, Pasciuto, Giulia, Tillack, Cornelia, Diegelmann, Julia, Pfennig, Simone, Konrad, Astrid, Schmechel, Silke, Wetzke, Martin, Török, Helga-Paula, Stallhofer, Johannes, Jürgens, Matthias, Griga, Thomas, Klein, Wolfram, Epplen, Jörg T., Schiemann, Uwe, Mussack, Thomas, Lohse, Peter, Göke, Burkhard, Ochsenkühn, Thomas, Folwaczny, Matthias, Müller-Myhsok, Bertram, Brand, Stephan

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Polymorphisms in theinterleukin-8 gene in patients with chronic obstructive pulmonary disease by Arinir, Umut, Klein, Wolfram, Rohde, Gernot, Stemmler, Susanne, Epplen, Joerg T., Schultze-Werninghaus, Gerhard

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