Search Results - "KLEIN, Robyn S"

Infectious immunity in the central nervous system and brain function by Klein, Robyn S, Garber, Charise, Howard, Nicole

“…Various neurotrophic pathogens are capable of infecting CNS tissues. Klein and colleagues review how immune responses and inflammation in the CNS affect brain…”
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Viral Encephalitis and Neurologic Diseases: Focus on Astrocytes by Soung, Allison, Klein, Robyn S.

“…Neurotropic RNA virus infections cause a major neurological disease burden. Due to the morbidity and mortality rates of viral encephalitides worldwide, there…”
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Protective and Pathological Immunity during Central Nervous System Infections by Klein, Robyn S., Hunter, Christopher A.

“…The concept of immune privilege of the central nervous system (CNS) has dominated the study of inflammatory processes in the brain. However, clinically…”
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Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise by Miner, Jonathan J., Cao, Bin, Govero, Jennifer, Smith, Amber M., Fernandez, Estefania, Cabrera, Omar H., Garber, Charise, Noll, Michelle, Klein, Robyn S., Noguchi, Kevin K., Mysorekar, Indira U., Diamond, Michael S.

“…Zika virus (ZIKV) infection in pregnant women causes intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we describe two mouse…”
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How COVID-19 shaped mental health: from infection to pandemic effects by Penninx, Brenda W. J. H., Benros, Michael E., Klein, Robyn S., Vinkers, Christiaan H.

“…The Coronavirus Disease 2019 (COVID-19) pandemic has threatened global mental health, both indirectly via disruptive societal changes and directly via…”
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CSF1R antagonism limits local restimulation of antiviral CD8 + T cells during viral encephalitis by Funk, Kristen E, Klein, Robyn S

“…Microglia are resident macrophages of the central nervous system (CNS) locally maintained through colony-stimulating factor 1 receptor (CSF1R) signaling…”
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Encephalitic Arboviruses of Africa: Emergence, Clinical Presentation and Neuropathogenesis by Klein, Robyn S

“…Many mosquito-borne viruses (arboviruses) are endemic in Africa, contributing to systemic and neurological infections in various geographical locations on the…”
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Type III Interferons: Emerging Roles in Autoimmunity by Manivasagam, Sindhu, Klein, Robyn S

“…Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines that play key roles in immune host defense at endothelial and…”
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COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital by Thakur, Kiran T, Miller, Emily Happy, Glendinning, Michael D, Al-Dalahmah, Osama, Banu, Matei A, Boehme, Amelia K, Boubour, Alexandra L, Bruce, Samuel S, Chong, Alexander M, Claassen, Jan, Faust, Phyllis L, Hargus, Gunnar, Hickman, Richard A, Jambawalikar, Sachin, Khandji, Alexander G, Kim, Carla Y, Klein, Robyn S, Lignelli-Dipple, Angela, Lin, Chun-Chieh, Liu, Yang, Miller, Michael L, Moonis, Gul, Nordvig, Anna S, Overdevest, Jonathan B, Prust, Morgan L, Przedborski, Serge, Roth, William H, Soung, Allison, Tanji, Kurenai, Teich, Andrew F, Agalliu, Dritan, Uhlemann, Anne-Catrin, Goldman, James E, Canoll, Peter

“…Many patients with SARS-CoV-2 infection develop neurological signs and symptoms, though, to date, little evidence exists that primary infection of the brain is…”
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Sex differences in cancer mechanisms by Rubin, Joshua B, Lagas, Joseph S, Broestl, Lauren, Sponagel, Jasmin, Rockwell, Nathan, Rhee, Gina, Rosen, Sarah F, Chen, Si, Klein, Robyn S, Imoukhuede, Princess, Luo, Jingqin

“…We now know that cancer is many different diseases, with great variation even within a single histological subtype. With the current emphasis on developing…”
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COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis by Soung, Allison L, Vanderheiden, Abigail, Nordvig, Anna S, Sissoko, Cheick A, Canoll, Peter, Mariani, Madeline B, Jiang, Xiaoping, Bricker, Traci, Rosoklija, Gorazd B, Arango, Victoria, Underwood, Mark, Mann, J John, Dwork, Andrew J, Goldman, James E, Boon, Adrianus C M, Boldrini, Maura, Klein, Robyn S

“…Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with acute and postacute cognitive and neuropsychiatric symptoms…”
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Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen by Santiago-Tirado, Felipe H, Onken, Michael D, Cooper, John A, Klein, Robyn S, Doering, Tamara L

“…The blood-brain barrier (BBB) protects the central nervous system (CNS) by restricting the passage of molecules and microorganisms. Despite this barrier,…”
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The blood–brain barrier, chemokines and multiple sclerosis by Holman, David W., Klein, Robyn S., Ransohoff, Richard M.

“…The infiltration of leukocytes into the central nervous system (CNS) is an essential step in the neuropathogenesis of multiple sclerosis (MS). Leukocyte…”
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Chemokines in the balance: maintenance of homeostasis and protection at CNS barriers by Williams, Jessica L, Holman, David W, Klein, Robyn S

“…In the adult central nervous system (CNS), chemokines and their receptors are involved in developmental, physiological and pathological processes. Although…”
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Quantification of increased cellularity during inflammatory demyelination by Wang, Yong, Wang, Qing, Haldar, Justin P., Yeh, Fang-Cheng, Xie, Mingqiang, Sun, Peng, Tu, Tsang-Wei, Trinkaus, Kathryn, Klein, Robyn S., Cross, Anne H., Song, Sheng-Kwei

“…Multiple sclerosis is characterized by inflammatory demyelination and irreversible axonal injury leading to permanent neurological disabilities. Diffusion…”
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CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination by Patel, Jigisha R., McCandless, Erin E., Dorsey, Denise, Klein, Robyn S., James, Anthony A.

“…Multiple sclerosis is a neurodegenerative disease characterized by episodes of autoimmune attack of oligodendrocytes leading to demyelination and progressive…”
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Knocking on Closed Doors: Host Interferons Dynamically Regulate Blood-Brain Barrier Function during Viral Infections of the Central Nervous System by Daniels, Brian P, Klein, Robyn S

“…  Neurotropic arboviruses capable of infecting the CNS include members of the Flaviviridae (e.g., West Nile and Japanese encephalitis viruses), Bunyaviridae…”
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The Olfactory Bulb: An Immunosensory Effector Organ during Neurotropic Viral Infections by Durrant, Douglas M, Ghosh, Soumitra, Klein, Robyn S

“…In 1935, the olfactory route was hypothesized to be a portal for virus entry into the central nervous system (CNS). This hypothesis was based on experiments in…”
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Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals by Daniels, Brian P, Holman, David W, Cruz-Orengo, Lillian, Jujjavarapu, Harsha, Durrant, Douglas M, Klein, Robyn S

“…Pattern recognition receptor (PRR) detection of pathogen-associated molecular patterns (PAMPs), such as viral RNA, drives innate immune responses against West…”
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Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection by Cain, Matthew D, Salimi, Hamid, Gong, Yongfeng, Yang, Lihua, Hamilton, Samantha L, Heffernan, James R, Hou, Jianghui, Miller, Mark J, Klein, Robyn S

“…Abstract Viral infections of the central nervous system (CNS) are often associated with blood-brain barrier (BBB) disruption, yet the impact of virus…”
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