Search Results - "KLEIN, OLIVER"

Delayed Autoimmune Toxicity Occurring Several Months After Cessation of Anti‐PD‐1 Therapy by Parakh, Sagun, Cebon, Jonathan, Klein, Oliver

“…Treatment with anti‐programmed cell death protein 1 (PD‐1) antibodies has demonstrated clinical efficacy in a whole range of malignancies including advanced…”
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TRANSNATIONAL NETWORKS OF PORK PRODUCTION: FRAGILE LINKAGES BETWEEN GERMANY AND CEE COUNTRIES by Klein, Oliver

“…The intention of this paper is to explore the internationalization efforts of German pork producers towards Central and Eastern Europe (CEE) with a special…”
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Enhancing therapeutic anti-cancer responses by combining immune checkpoint and tyrosine kinase inhibition by Daly, Roger J, Scott, Andrew M, Klein, Oliver, Ernst, Matthias

“…Over the past decade, immune checkpoint inhibitor (ICI) therapy has been established as the standard of care for many types of cancer, but the strategies…”
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Mechanical Unloading by Fulminant Myocarditis: LV-IMPELLA, ECMELLA, BI-PELLA, and PROPELLA Concepts by Tschöpe, Carsten, Van Linthout, Sophie, Klein, Oliver, Mairinger, Thomas, Krackhardt, Florian, Potapov, Evgenij V., Schmidt, Gunther, Burkhoff, Daniel, Pieske, Burkert, Spillmann, Frank

“…Mechanical circulatory support (MCS) is often required to stabilize patients with acute fulminant myocarditis with cardiogenic shock. This review gives an…”
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Multiplex enzyme activity imaging by MALDI-IMS of substrate library conversions by Klein, Oliver, Haeckel, Akvile, Reimer, Ulf, Nebrich, Grit, Schellenberger, Eyk

“…Enzymes are fundamental to biological processes and involved in most pathologies. Here we demonstrate the concept of simultaneously mapping multiple enzyme…”
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Killing hypoxic cell populations in a 3D tumor model with EtNBS-PDT by Evans, Conor L, Abu-Yousif, Adnan O, Park, Yong Jin, Klein, Oliver J, Celli, Jonathan P, Rizvi, Imran, Zheng, Xiang, Hasan, Tayyaba

“…An outstanding problem in cancer therapy is the battle against treatment-resistant disease. This is especially true for ovarian cancer, where the majority of…”
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Longitudinal, label-free, quantitative tracking of cell death and viability in a 3D tumor model with OCT by Jung, Yookyung, Klein, Oliver J., Wang, Hequn, Evans, Conor L.

“…Three-dimensional in vitro tumor models are highly useful tools for studying tumor growth and treatment response of malignancies such as ovarian cancer…”
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Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum by Vollstädt-Klein, Sabine, Wichert, Svenja, Rabinstein, Juri, Bühler, Mira, Klein, Oliver, Ende, Gabriele, Hermann, Derik, Mann, Karl

“…ABSTRACT Aims  During the development of drug addiction, initial hedonic effects decrease when substance use becomes habitual and ultimately compulsive. Animal…”
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Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells by Geissler, Sven, Textor, Martin, Kühnisch, Jirko, Könnig, Delia, Klein, Oliver, Ode, Andrea, Pfitzner, Tilman, Adjaye, James, Kasper, Grit, Duda, Georg N

“…Mesenchymal stromal cells (MSCs) are of high relevance for the regeneration of mesenchymal tissues such as bone and cartilage. The promising role of MSCs in…”
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Click-Assembled, Oxygen-Sensing Nanoconjugates for Depth-Resolved, Near-Infrared Imaging in a 3 D Cancer Model by Nichols, Alexander J., Roussakis, Emmanuel, Klein, Oliver J., Evans, Conor L.

“…Hypoxia is an important contributing factor to the development of drug‐resistant cancer, yet few nonperturbative tools exist for studying oxygenation in…”
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Mode-of-action of the PROPELLA concept in fulminant myocarditis by Spillmann, Frank, Van Linthout, Sophie, Schmidt, Gunther, Klein, Oliver, Hamdani, Nazha, Mairinger, Thomas, Krackhardt, Florian, Maroski, Bastian, Schlabs, Thomas, Soltani, Sajjad, Anker, Stefan, Potapov, Evgenij V, Burkhoff, Daniel, Pieske, Burkert, Tschöpe, Carsten

“…Abstract Aims Haemodynamic load induces cardiac remodelling via mechano-transduction pathways, which can further trigger inflammatory responses. We…”
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Anti-programmed cell death protein 1 (anti-PD1) immunotherapy induced autoimmune polyendocrine syndrome type II (APS-2): a case report and review of the literature by Gunjur, Ashray, Klein, Oliver, Kee, Damien, Cebon, Jonathan

“…Autoimmune polyendocrine syndrome type II (APS-2) is a rare constellation of autoimmune hypoadrenalism, thyroid dysfunction and/or type 1 diabetes (T1DM),…”
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Optimizing environmental enrichment for Sprague Dawley rats: Exemplary insights into the liver proteome by Roschke, Nathalie N, Hillebrandt, Karl H, Polenz, Dietrich, Klein, Oliver, Gassner, Joseph M G V, Pratschke, Johann, Krenzien, Felix, Sauer, Igor M, Raschzok, Nathanael, Moosburner, Simon

“…Considering the expected increase in the elderly population and the growing emphasis on aging-related biomedical research, the demand for aged laboratory…”
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Collagen Fibrils Mechanically Contribute to Tissue Contraction in an In Vitro Wound Healing Scenario by Brauer, Erik, Lippens, Evi, Klein, Oliver, Nebrich, Grit, Schreivogel, Sophie, Korus, Gabriela, Duda, Georg N., Petersen, Ansgar

“…Wound contraction is an ancient survival mechanism of vertebrates that results from tensile forces supporting wound closure. So far, tissue tension was…”
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PLGA nanoparticle encapsulation reduces toxicity while retaining the therapeutic efficacy of EtNBS-PDT in vitro by Hung, Hsin-I, Klein, Oliver J., Peterson, Sam W., Rokosh, Sarah R., Osseiran, Sam, Nowell, Nicholas H., Evans, Conor L.

“…Photodynamic therapy regimens, which use light-activated molecules known as photosensitizers, are highly selective against many malignancies and can bypass…”
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Propagation and annihilation of threading dislocations during off-axis growth of heteroepitaxial diamond films by Klein, Oliver, Mayr, Michael, Fischer, Martin, Gsell, Stefan, Schreck, Matthias

“…Threading dislocations in heteroepitaxial diamond films deposited on Ir/YSZ/Si(001) substrates with an off-axis angle of 4° towards [100] have been studied by…”
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In Situ N -Glycosylation Signatures of Epithelial Ovarian Cancer Tissue as Defined by MALDI Mass Spectrometry Imaging by Grzeski, Marta, Taube, Eliane T, Braicu, Elena I, Sehouli, Jalid, Blanchard, Véronique, Klein, Oliver

“…The particularly high mortality of epithelial ovarian cancer (EOC) is in part linked to limited understanding of its molecular signatures. Although there are…”
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Safety and efficacy of clip‐based vs. suture mediated vascular closure for femoral access hemostasis: A prospective randomized single center study comparing the StarClose and the ProGlide device by Klein‐Wiele, Oliver, Baliota, Maria, Kara, Kaffer, Käunicke, Matthias, Schäfer, Harald, Garbrecht, Marc, Abdulghafor, Marwan, Garmer, Marietta, Hailer, Birgit

“…Objectives This study is the first head‐to‐head analysis of StarClose vs. ProGlide in patients undergoing 5F or 6F percutaneous coronary catheterization or…”
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Towards a Novel Patch Material for Cardiac Applications: Tissue-Specific Extracellular Matrix Introduces Essential Key Features to Decellularized Amniotic Membrane by Becker, Matthias, Maring, Janita A, Schneider, Maria, Herrera Martin, Aarón X, Seifert, Martina, Klein, Oliver, Braun, Thorsten, Falk, Volkmar, Stamm, Christof

“…There is a growing need for scaffold material with tissue-specific bioactivity for use in regenerative medicine, tissue engineering, and for surgical repair of…”
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An Integrin-Targeted, Highly Diffusive Construct for Photodynamic Therapy by Klein, Oliver J., Yuan, Hushan, Nowell, Nicholas H., Kaittanis, Charalambos, Josephson, Lee, Evans, Conor L.

“…Targeted antineoplastic agents show great promise in the treatment of cancer, having the ability to impart cytotoxicity only to specific tumor types. However,…”
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