Search Results - "KLEANTHOUS, Harry"

Scientific rationale for developing potent RBD-based vaccines targeting COVID-19 by Kleanthous, Harry, Silverman, Judith Maxwell, Makar, Karen W., Yoon, In-Kyu, Jackson, Nicholas, Vaughn, David W.

“…Vaccination of the global population against COVID-19 is a great scientific, logistical, and moral challenge. Despite the rapid development and authorization…”
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CX3CR1 Is Expressed in Differentiated Human Ciliated Airway Cells and Co-Localizes with Respiratory Syncytial Virus on Cilia in a G Protein-Dependent Manner by Jeong, Kwang-Il, Piepenhagen, Peter A, Kishko, Michael, DiNapoli, Joshua M, Groppo, Rachel P, Zhang, Linong, Almond, Jeffrey, Kleanthous, Harry, Delagrave, Simon, Parrington, Mark

“…Respiratory syncytial virus (RSV) is the principal cause of bronchiolitis in infants and a significant healthcare problem. The RSV Glycoprotein (G) mediates…”
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Antibody-mediated NK cell activation as a correlate of immunity against influenza infection by Boudreau, Carolyn M., Burke, John S., Yousif, Ashraf S., Sangesland, Maya, Jastrzebski, Sandra, Verschoor, Chris, Kuchel, George, Lingwood, Daniel, Kleanthous, Harry, De Bruijn, Iris, Landolfi, Victoria, Sridhar, Saranya, Alter, Galit

“…Antibodies play a critical role in protection against influenza; yet titers and viral neutralization represent incomplete correlates of immunity. Instead, the…”
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Antibodies directed towards neuraminidase restrict influenza virus replication in primary human bronchial epithelial cells by Smet, Anouk, Catani, Joao Paulo Portela, Ysenbaert, Tine, Gonçalves, Amanda, Kleanthous, Harry, Vogel, Thorsten U, Saelens, Xavier, Job, Emma R

“…Influenza neuraminidase (NA) is implicated in various aspects of the virus replication cycle and therefore is an attractive target for vaccination and…”
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Impact of age and pre-existing influenza immune responses in humans receiving split inactivated influenza vaccine on the induction of the breadth of antibodies to influenza A strains by Nuñez, Ivette A, Carlock, Michael A, Allen, James D, Owino, Simon O, Moehling, Krissy K, Nowalk, Patricia, Susick, Michael, Diagle, Kensington, Sweeney, Kristen, Mundle, Sophia, Vogel, Thorsten U, Delagrave, Simon, Ramgopal, Moti, Zimmerman, Richard K, Kleanthous, Harry, Ross, Ted M

“…Most humans have pre-existing immunity to influenza viruses. In this study, volunteers (ages of 18-85 years) were vaccinated with split, inactivated Fluzone™…”
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A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses by Shen, Chenguang, Chen, Junyu, Li, Rui, Zhang, Mengya, Wang, Guosong, Stegalkina, Svetlana, Zhang, Limin, Chen, Jing, Cao, Jianli, Bi, Xingjian, Anderson, Stephen F, Alefantis, Timothy, Zhang, Minwei, Cai, Xiaoyang, Yang, Kunyu, Zheng, Qingbing, Fang, Mujing, Yu, Hai, Luo, Wenxin, Zheng, Zizheng, Yuan, Quan, Zhang, Jun, Wai-Kuo Shih, James, Kleanthous, Harry, Chen, Honglin, Chen, Yixin, Xia, Ningshao

“…Influenza B virus causes considerable disease burden worldwide annually, highlighting the limitations of current influenza vaccines and antiviral drugs. In…”
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Mapping of a Novel H3-Specific Broadly Neutralizing Monoclonal Antibody Targeting the Hemagglutinin Globular Head Isolated from an Elite Influenza Virus-Immunized Donor Exhibiting Serological Breadth by Qiu, Yu, Stegalkina, Svetlana, Zhang, Jianxin, Boudanova, Ekaterina, Park, Anna, Zhou, Yanfeng, Prabakaran, Ponraj, Pougatcheva, Svetlana, Ustyugova, Irina V, Vogel, Thorsten U, Mundle, Sophia T, Oomen, Ray, Delagrave, Simon, Ross, Ted M, Kleanthous, Harry, Qiu, Huawei

“…The discovery of potent and broadly protective influenza virus epitopes could lead to improved vaccines that are resistant to antigenic drift. Here, we…”
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Impact of age and pre-existing immunity on the induction of human antibody responses against influenza B viruses by Carlock, Michael A., Ingram, John G., Clutter, Emily F., Cecil, Noah C., Ramgopal, Moti, Zimmerman, Richard K., Warren, William, Kleanthous, Harry, Ross, Ted M.

“…Pre-existing immunity to influenza is dependent on a number of factors and can vary greatly within and across influenza subtypes. In this study, volunteers…”
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Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants by Bajoria, Sakshi, Kaur, Kawaljit, Kumru, Ozan S., Van Slyke, Greta, Doering, Jennifer, Novak, Hayley, Rodriguez Aponte, Sergio A., Dalvie, Neil C., Naranjo, Christopher A., Johnston, Ryan S., Silverman, Judith Maxwell, Kleanthous, Harry, Love, J. Christopher, Mantis, Nicholas J., Joshi, Sangeeta B., Volkin, David B.

“…Low-cost, refrigerator-stable COVID-19 vaccines will facilitate global access and improve vaccine coverage in low- and middle-income countries. To this end,…”
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Enhancing Immunogenicity of a Thermostable, Efficacious SARS-CoV-2 Vaccine Formulation through Oligomerization and Adjuvant Choice by Khan, Mohammad Suhail, Jakob, Virginie, Singh, Randhir, Rajmani, Raju S, Kumar, Sahil, Lemoine, Céline, Kleanthous, Harry, Ringe, Rajesh P, Dubois, Patrice M, Varadarajan, Raghavan

“…Currently deployed SARS-CoV-2 vaccines all require storage at refrigerated or sub-zero temperatures. We demonstrate that after month-long incubation at 37 °C,…”
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Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD) by Kumru, Ozan S., Bajoria, Sakshi, Kaur, Kawaljit, Hickey, John M., Van Slyke, Greta, Doering, Jennifer, Berman, Katherine, Richardson, Charles, Lien, Hans, Kleanthous, Harry, Mantis, Nicholas J., Joshi, Sangeeta B., Volkin, David B.

“…Second-generation COVID-19 vaccines with improved immunogenicity (e.g., breadth, duration) and availability (e.g., lower costs, refrigerator stable) are needed…”
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Core bead chromatography for preparation of highly pure, infectious respiratory syncytial virus in the negative purification mode by Mundle, Sophia T, Kishko, Michael, Groppo, Rachel, DiNapoli, Joshua, Hamberger, John, McNeil, Bryan, Kleanthous, Harry, Parrington, Mark, Zhang, Linong, Anderson, Stephen F

“…Highlights • A purification procedure for respiratory syncytial virus is described. • Purification is achieved by core bead chromatography followed by…”
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Single-dose vaccine against tick-borne encephalitis by Rumyantsev, Alexander A., Goncalvez, Ana P., Giel-Moloney, Maryann, Catalan, John, Liu, Yuxi, Gao, Qing-sheng, Almond, Jeff, Kleanthous, Harry, Pugachev, Konstantin V.

“…Tick-borne encephalitis (TBE) virus is the most important human pathogen transmitted by ticks in Eurasia. Inactivated vaccines are available but require…”
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High-purity preparation of HSV-2 vaccine candidate ACAM529 is immunogenic and efficacious in vivo by Mundle, Sophia T, Hernandez, Hector, Hamberger, John, Catalan, John, Zhou, Changhong, Stegalkina, Svetlana, Tiffany, Andrea, Kleanthous, Harry, Delagrave, Simon, Anderson, Stephen F

“…Genital herpes is a sexually transmitted infection (STI) caused by herpes simplex virus 2 (HSV-2) and to a lesser extent herpes simplex virus 1 (HSV-1)…”
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Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018TM Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen by Bajoria, Sakshi, Kumru, Ozan S., Doering, Jennifer, Berman, Katherine, Slyke, Greta Van, Prigodich, Anneka, Rodriguez-Aponte, Sergio A., Kleanthous, Harry, Love, J. Christopher, Mantis, Nicholas J., Joshi, Sangeeta B., Volkin, David B.

“…Aluminum-salt vaccine adjuvants (alum) are commercially available as micron-sized particles with varying chemical composition and crystallinity. There are…”
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Enhanced protective efficacy of a thermostable RBD-S2 vaccine formulation against SARS-CoV-2 and its variants by Mittal, Nidhi, Kumar, Sahil, Rajmani, Raju S., Singh, Randhir, Lemoine, Céline, Jakob, Virginie, BJ, Sowrabha, Jagannath, Nayana, Bhat, Madhuraj, Chakraborty, Debajyoti, Pandey, Suman, Jory, Aurélie, SA, Suba Soundarya, Kleanthous, Harry, Dubois, Patrice, Ringe, Rajesh P., Varadarajan, Raghavan

“…With the rapid emergence of variants of concern (VOC), the efficacy of currently licensed vaccines has reduced drastically. VOC mutations largely occur in the…”
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Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques by Jacob-Dolan, Catherine, Yu, Jingyou, McMahan, Katherine, Giffin, Victoria, Chandrashekar, Abishek, Martinot, Amanda J., Anioke, Tochi, Powers, Olivia C., Hall, Kevin, Hope, David, Miller, Jessica, Hachmann, Nichole P., Chung, Benjamin, Gardner, Sarah, Sellers, Daniel, Barrett, Julia, Lewis, Mark G., Andersen, Hanne, Kleanthous, Harry, Seo, Ki-Woen, Lee, Su Jeen, Park, Yong Wook, Kim, Hun, Barouch, Dan H.

“…Despite the availability of several effective SARS-CoV-2 vaccines, additional vaccines will be required for optimal global vaccination. In this study, we…”
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Immunogenicity and efficacy of intramuscular replication-defective and subunit vaccines against herpes simplex virus type 2 in the mouse genital model by Delagrave, Simon, Hernandez, Hector, Zhou, Changhong, Hamberger, John F, Mundle, Sophia T, Catalan, John, Baloglu, Simge, Anderson, Stephen F, DiNapoli, Joshua M, Londoño-Hayes, Patricia, Parrington, Mark, Almond, Jeffrey, Kleanthous, Harry

“…Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus that is highly prevalent worldwide, causing a range of symptoms that result in significant…”
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Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B by Liu, Jinyu, Kothe, Michael, Zhang, Jianxin, Oloo, Eliud, Stegalkina, Svetlana, Mundle, Sophia T., Li, Lu, Zhang, Jinrong, Cole, Leah E., Barone, Lucianna, Biemann, Hans-Peter, Kleanthous, Harry, Anosova, Natalie G., Anderson, Stephen F.

“…Clostridium difficile toxins are the primary causative agents for hospital-acquired diarrhea and pseudomembranous colitis. Numerous monoclonal antibodies…”
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Application of replication-defective West Nile virus vector to non-flavivirus vaccine targets by Giel-Moloney, Maryann, Vaine, Michael, Zhang, Linong, Parrington, Mark, Gajewska, Beata, Vogel, Thorsten U., Pougatcheva, Svetlana O., Duan, Xiaochu, Farrell, Timothy, Ustyugova, Irina, Phogat, Sanjay, Kleanthous, Harry, Pugachev, Konstantin V.

“…The RepliVax vaccine platform(RV) is based on flavivirus genomes that are rationally attenuated by deletion. The self-limiting infection provided by RV has…”
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