Search Results - "KLAUSHOFER, K"

Vibrational spectroscopic techniques to assess bone quality by Paschalis, E. P., Gamsjaeger, S., Klaushofer, K.

“…Although musculoskeletal diseases such as osteoporosis are diagnosed and treatment outcome is evaluated based mainly on routine clinical outcomes of bone…”
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Bone mineralization density distribution in health and disease by Roschger, P, Paschalis, E.P, Fratzl, P, Klaushofer, K

“…Abstract Human cortical and trabecular bones are formed by individual osteons and bone packets, respectively, which are produced at different time points…”
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Antiresorptive therapy and risk of mortality and refracture in osteoporosis-related hip fracture: a nationwide study by Brozek, W., Reichardt, B., Zwerina, J., Dimai, H. P., Klaushofer, K., Zwettler, E.

“…Summary We analyzed the association of bisphosphonate therapy with mortality and hip refracture incidence among osteoporosis-related hip fracture patients in…”
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The contribution of the pericanalicular matrix to mineral content in human osteonal bone by Roschger, A., Roschger, P., Wagermaier, W., Chen, J., van Tol, A.F., Repp, F., Blouin, S., Berzlanovich, A., Gruber, G.M., Klaushofer, K., Fratzl, P., Weinkamer, R.

“…The osteocyte lacunar-canalicular network (LCN) penetrates bone and houses the osteocytes and their processes. Despite its rather low volume fraction, the LCN…”
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Spatial distribution of the trace elements zinc, strontium and lead in human bone tissue by Pemmer, B, Roschger, A, Wastl, A, Hofstaetter, J.G, Wobrauschek, P, Simon, R, Thaler, H.W, Roschger, P, Klaushofer, K, Streli, C

“…Abstract Trace elements are chemical elements in minute quantities, which are known to accumulate in the bone. Cortical and trabecular bones consist of bone…”
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Fourier Transform Infrared Spectroscopic Characterization of Mineralizing Type I Collagen Enzymatic Trivalent Cross-Links by Paschalis, E. P., Gamsjaeger, S., Tatakis, D. N., Hassler, N., Robins, S. P., Klaushofer, K.

“…The most abundant protein of bone’s organic matrix is collagen. One of its most important properties is its cross-linking pattern, which is responsible for the…”
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The bone mineralization density distribution as a fingerprint of the mineralization process by Ruffoni, D, Fratzl, P, Roschger, P, Klaushofer, K, Weinkamer, R

“…Abstract The inhomogeneous mineral content and its topographical distribution on a microscopic scale are major determinants of the mechanical quality of…”
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Estrogen depletion alters mineralization regulation mechanisms in an ovariectomized monkey animal model by Paschalis, E.P., Gamsjaeger, S., Condon, K., Klaushofer, K., Burr, D.

“…Ovariectomized animal models have been extensively used in osteoporosis research due to the resulting loss of bone mass. The purpose of the present study was…”
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Novel familial mutation of LRP5 causing high bone mass: Genetic analysis, clinical presentation, and characterization of bone matrix mineralization by Roetzer, K.M., Uyanik, G., Brehm, A., Zwerina, J., Zandieh, S., Czech, T., Roschger, P., Misof, B.M., Klaushofer, K.

“…The Wnt signalling pathway is a critical regulator of bone mass and quality. Several heterozygous mutations in the LRP5 gene, a Wnt co-receptor, causing high…”
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Cortical bone composition and orientation as a function of animal and tissue age in mice by Raman spectroscopy by Gamsjaeger, Sonja, Masic, A, Roschger, P, Kazanci, M, Dunlop, J.W.C, Klaushofer, K, Paschalis, E.P, Fratzl, P

“…Abstract Important aspects of bone tissue quality include the physicochemical properties of its main constituents, the organic matrix and the mineral crystals…”
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Ovarian hormone depletion affects cortical bone quality differently on different skeletal envelopes by Paschalis, E.P, Gamsjaeger, S, Hassler, N, Klaushofer, K, Burr, D

“…Abstract The physical properties of bone tissue are determined by the organic and mineral matrix, and are one aspect of bone quality. As such, the properties…”
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Vitamin D and calcium supplementation for three years in postmenopausal osteoporosis significantly alters bone mineral and organic matrix quality by Paschalis, E.P, Gamsjaeger, S, Hassler, N, Fahrleitner-Pammer, A, Dobnig, H, Stepan, J.J, Pavo, I, Eriksen, E.F, Klaushofer, K

“…Abstract Prospective, controlled clinical trials in postmenopausal osteoporosis typically compare effects of an active drug with placebo in addition to vitamin…”
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Pediatric reference Raman data for material characteristics of iliac trabecular bone by Gamsjaeger, S, Hofstetter, B, Fratzl-Zelman, N, Roschger, P, Roschger, A, Fratzl, P, Brozek, W, Masic, A, Misof, B.M, Glorieux, F.H, Klaushofer, K, Rauch, F, Paschalis, E.P

“…Abstract Bone material characteristics are important contributors in the determination of bone strength. Raman spectroscopic analysis provides information on…”
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Lathyrism-induced alterations in collagen cross-links influence the mechanical properties of bone material without affecting the mineral by Paschalis, E.P, Tatakis, D.N, Robins, S, Fratzl, P, Manjubala, I, Zoehrer, R, Gamsjaeger, S, Buchinger, B, Roschger, A, Phipps, R, Boskey, A.L, Dall'Ara, E, Varga, P, Zysset, P, Klaushofer, K, Roschger, P

“…Abstract In the present study a rat animal model of lathyrism was employed to decipher whether anatomically confined alterations in collagen cross-links are…”
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Organic matrix quality discriminates between age- and BMD-matched fracturing versus non-fracturing post-menopausal women: A pilot study by Rokidi, S., Paschalis, E.P., Klaushofer, K., Vennin, S., Desyatova, A., Turner, J.A., Watson, P., Lappe, J., Akhter, M.P., Recker, R.R.

“…Women with similar areal Bone Mineral Densities (BMD) may show divergent fracture incidence due to differences in bone quality. The hypothesis tested in the…”
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Osteoclasts on Bone and Dentin In Vitro: Mechanism of Trail Formation and Comparison of Resorption Behavior by Rumpler, M., Würger, T., Roschger, P., Zwettler, E., Sturmlechner, I., Altmann, P., Fratzl, P., Rogers, M. J., Klaushofer, K.

“…The main function of osteoclasts in vivo is the resorption of bone matrix, leaving behind typical resorption traces consisting of pits and trails. The…”
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Bone osteonal tissues by Raman spectral mapping: Orientation–composition by Kazanci, M., Roschger, P., Paschalis, E.P., Klaushofer, K., Fratzl, P.

“…Bone is a composite material with a hierarchical structure. Its strength depends on its structural and material properties. In the present study, Raman…”
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Use of proton pump inhibitors and mortality after hip fracture in a nationwide study by Brozek, W., Reichardt, B., Zwerina, J., Dimai, H. P., Klaushofer, K., Zwettler, E.

“…Summary We analyzed the association of proton pump inhibitors (PPIs) with mortality after osteoporosis-related hip fracture in Austria. PPIs were associated…”
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Complementary information on in vitro conversion of amorphous (precursor) calcium phosphate to hydroxyapatite from Raman microspectroscopy and wide-angle X-ray scattering by Kazanci, M, Fratzl, P, Klaushofer, K, Paschalis, E P

“…In addition to mechanical functions, bones have an essential role in metabolic activity as mineral reservoirs that are able to absorb and release ions…”
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Normative data on mineralization density distribution in iliac bone biopsies of children, adolescents and young adults by Fratzl-Zelman, N, Roschger, P, Misof, B.M, Pfeffer, S, Glorieux, F.H, Klaushofer, K, Rauch, F

“…Abstract Bone mineralization density distribution (BMDD) as assessed by quantitative backscattered electron imaging (qBEI) in iliac crest bone biopsies has…”
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