Search Results - "KLATZMANN, David"

The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases by Klatzmann, David, Abbas, Abul K.

“…Key Points Interleukin-2 (IL-2) was discovered as a cytokine that supports the proliferation and differentiation of effector T cells. IL-2 initially entered…”
Get full text

Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction by Zacchigna, Serena, Martinelli, Valentina, Moimas, Silvia, Colliva, Andrea, Anzini, Marco, Nordio, Andrea, Costa, Alessia, Rehman, Michael, Vodret, Simone, Pierro, Cristina, Colussi, Giulia, Zentilin, Lorena, Gutierrez, Maria Ines, Dirkx, Ellen, Long, Carlin, Sinagra, Gianfranco, Klatzmann, David, Giacca, Mauro

“…Cardiomyocyte proliferation stops at birth when the heart is no longer exposed to maternal blood and, likewise, to regulatory T cells (Tregs) that are expanded…”
Get full text

Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases by Dragin, Nadine, Bismuth, Jacky, Cizeron-Clairac, Géraldine, Biferi, Maria Grazia, Berthault, Claire, Serraf, Alain, Nottin, Rémi, Klatzmann, David, Cumano, Ana, Barkats, Martine, Le Panse, Rozen, Berrih-Aknin, Sonia

“…Autoimmune diseases affect 5% to 8% of the population, and females are more susceptible to these diseases than males. Here, we analyzed human thymic…”
Get full text

T follicular helper and T follicular regulatory cells have different TCR specificity by Maceiras de Oliveira, Ana Raquel, Almeida, Silvia Cristina Paiva, Mariotti-Ferrandiz, Encarnita, Chaara, Wahiba, Jebbawi, Fadi, Six, Adrien, Hori, Shohei, Klatzmann, David, Faro, Jose, Silva Graca, Luis Ricardo

“…© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this…”
Get full text

Anticancer immunotherapy by CTLA-4 blockade： obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25 by Hannani, Dalil, Vétizou, Marie, Enot, David, Rusakiewicz, Sylvie, Chaput, Nathalie, Klatzmann, David, Desbois, Melanie, Jacquelot, Nicolas, Vimond, Nadège, Chouaib, Salem, Mateus, Christine, Allison, James P, Ribas, Antoni, Wolchok, Jedd D, Yuan, Jianda, Wong, Philip, Postow, Michael, Mackiewicz, Andrzej, Mackiewicz, Jacek, Schadendorff, Dirk, Jaeger, Dirk, Korman, Alan J, Bahjat, Keith, Maio, Michele, Calabro, Luana, Teng, Michele WL, Smyth, Mark J, Eggermont, Alexander, Robert, Caroline, Kroemer, Guido, Zitvogel, Laurence

“…The cytotoxic T lymphocyte antigen-4 （CTLA-4）-blocking antibody ipilimumab induces immune-mediated longterm control of metastatic melanoma in a fraction of…”
Get full text

Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells by Ritvo, Paul-Gydéon, Klatzmann, David

“…The role of interleukin-1 in the regulation of humoral responses is poorly documented, in contrast to its role in inflammation. Recent findings suggest there…”
Get full text

The Tsallis generalized entropy enhances the interpretation of transcriptomics datasets by Dérian, Nicolas, Pham, Hang-Phuong, Nehar-Belaid, Djamel, Tchitchek, Nicolas, Klatzmann, David, Eric, Vicaut, Six, Adrien

“…Identifying differentially expressed genes between experimental conditions is still the gold-standard approach to interpret transcriptomic profiles…”
Get full text

Immune checkpoint inhibitor-induced myositis, the earliest and most lethal complication among rheumatic and musculoskeletal toxicities by Allenbach, Yves, Anquetil, Céline, Manouchehri, Ali, Benveniste, Olivier, Lambotte, Olivier, Lebrun-Vignes, Bénédicte, Spano, Jean-Philippe, Ederhy, Stéphane, Klatzmann, David, Rosenzwajg, Michelle, Fautrel, Bruno, Cadranel, Jacques, Johnson, Douglas B., Moslehi, Javid J., Salem, Joe-Elie

“…In addition to restoring anti-tumor immune responses, immune checkpoint inhibitors (ICI) may also induce immune-related adverse events (irAE) that can affect…”
Get full text

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial by Hartemann, Agnès, Prof, Bensimon, Gilbert, MD, Payan, Christine A, MD, Jacqueminet, Sophie, MD, Bourron, Olivier, MD, Nicolas, Nathalie, MD, Fonfrede, Michèle, MD, Rosenzwajg, Michelle, MD, Bernard, Claude, PharmD, Klatzmann, David, Prof

“…Summary Background An improper balance of regulatory/effector T (Treg /Teff ) cells is central to the development of autoimmune diseases, including type 1…”
Get full text

High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells by Ritvo, Paul-Gydeon, Saadawi, Ahmed, Barennes, Pierre, Quiniou, Valentin, Chaara, Wahiba, Soufi, Karim El, Bonnet, Benjamin, Six, Adrien, Shugay, Mikhail, Mariotti-Ferrandiz, Encarnita, Klatzmann, David

“…T follicular helper (Tfh) and regulatory (Tfr) cells are terminally differentiated cells found in germinal centers (GCs), specialized secondary lymphoid organ…”
Get full text

Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis by Antoun, Stephanie, Ellul, Pierre, Peyre, Hugo, Rosenzwajg, Michelle, Gressens, Pierre, Klatzmann, David, Delorme, Richard

“…Abstract Background Fever during pregnancy is a relatively common and most often trivial event. However, under specific conditions, it could affect…”
Get full text

Abnormal neutrophil-to-lymphocyte ratio in children with autism spectrum disorder and history of maternal immune activation by Ellul, Pierre, Maruani, Anna, Peyre, Hugo, Vantalon, Valérie, Hoareau, Daphnée, Tiercelin, Hugo, Rosenzwajg, Michelle, Klatzmann, David, Delorme, Richard

“…Maternal immune activation (MIA), related to autoimmune/inflammatory diseases or acute infections, during the two first trimesters of pregnancy is a risk…”
Get full text

Interleukin-5–producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy by Van Gool, Frédéric, Molofsky, Ari B., Morar, Malika M., Rosenzwajg, Michelle, Liang, Hong-Erh, Klatzmann, David, Locksley, Richard M., Bluestone, Jeffrey A.

“…Interleukin (IL)-2 promotes regulatory T-cell development and function, and treatment with IL-2 is being tested as therapy for some autoimmune diseases…”
Get full text

Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins by Serradell, Marianela C., Rupil, Lucía L., Martino, Román A., Prucca, César G., Carranza, Pedro G., Saura, Alicia, Fernández, Elmer A., Gargantini, Pablo R., Tenaglia, Albano H., Petiti, Juan P., Tonelli, Renata R., Reinoso-Vizcaino, Nicolás, Echenique, José, Berod, Luciana, Piaggio, Eliane, Bellier, Bertrand, Sparwasser, Tim, Klatzmann, David, Luján, Hugo D.

“…Intestinal and free-living protozoa, such as Giardia lamblia , express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects…”
Get full text

Neutrophil-Platelet and Monocyte-Platelet Aggregates in COVID-19 Patients by Le Joncour, Alexandre, Biard, Lucie, Vautier, Mathieu, Bugaut, Helene, Mekinian, Arsene, Maalouf, Georgina, Vieira, Matheus, Marcelin, Anne-Geneviève, Rosenzwajg, Michelle, Klatzmann, David, Corvol, Jean-Christophe, Paccoud, Olivier, Carillion, Aude, Salem, Joe-Elie, Cacoub, Patrice, Boulaftali, Yacine, Saadoun, David

Get more information

Molecular signatures of neural connectivity in the olfactory cortex by Diodato, Assunta, Ruinart de Brimont, Marion, Yim, Yeong Shin, Derian, Nicolas, Perrin, Sandrine, Pouch, Juliette, Klatzmann, David, Garel, Sonia, Choi, Gloria B, Fleischmann, Alexander

“…The ability to target subclasses of neurons with defined connectivity is crucial for uncovering neural circuit functions. The olfactory (piriform) cortex is…”
Get full text

Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells by Lecendreux, Michel, Churlaud, Guillaume, Pitoiset, Fabien, Regnault, Armelle, Tran, Tu Anh, Liblau, Roland, Klatzmann, David, Rosenzwajg, Michelle

“…Narcolepsy is a rare neurologic disorder characterized by excessive daytime sleepiness, cataplexy and disturbed nocturnal sleep patterns. Narcolepsy type 1…”
Get full text

Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder by Ellul, Pierre, Mariotti-Ferrandiz, Encarnita, Leboyer, Marion, Klatzmann, David

“…There is growing evidence that inflammation plays a role in major depressive disorder (MDD). As the main role of regulatory T cells (Tregs) is to control…”
Get full text

Immunological causes of obsessive-compulsive disorder: is it time for the concept of an “autoimmune OCD” subtype? by Endres, Dominique, Pollak, Thomas A., Bechter, Karl, Denzel, Dominik, Pitsch, Karoline, Nickel, Kathrin, Runge, Kimon, Pankratz, Benjamin, Klatzmann, David, Tamouza, Ryad, Mallet, Luc, Leboyer, Marion, Prüss, Harald, Voderholzer, Ulrich, Cunningham, Janet L., Domschke, Katharina, Tebartz van Elst, Ludger, Schiele, Miriam A.

“…Obsessive-compulsive disorder (OCD) is a highly disabling mental illness that can be divided into frequent primary and rarer organic secondary forms. Its…”
Get full text

Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis by Ellul, Pierre, Rosenzwajg, Michelle, Peyre, Hugo, Fourcade, Gwladys, Mariotti-Ferrandiz, Encarnita, Trebossen, Vincent, Klatzmann, David, Delorme, Richard

“…Immune system dysfunction has been proposed to play a critical role in the pathophysiology of autism spectrum disorders (ASD). Conflicting reports of…”
Get full text