Search Results - "KLASA, R"

Favorable outcome of primary mediastinal large B-cell lymphoma in a single institution: the British Columbia experience by Savage, K. J., Al-Rajhi, N., Voss, N., Paltiel, C., Klasa, R., Gascoyne, R. D., Connors, J. M.

“…Background: Primary mediastinal large B-cell lymphoma (PMBCL) is a distinct clinico-pathological subtype of diffuse large B-cell lymphoma (DLBCL). The optimal…”
Get full text

Outcome of patients with primary refractory diffuse large B cell lymphoma after R-CHOP treatment by Hitz, Felicitas, Connors, J. M., Gascoyne, R. D., Hoskins, P., Moccia, A., Savage, K. J., Sehn, L. H., Shenkier, T., Villa, D., Klasa, R.

“…Primary refractory diffuse large B cell lymphoma (DLBCL) following R-CHOP chemotherapy is a major concern. We identified 1126 patients with DLBCL treated with…”
Get full text

Patterns of Outcome and Prognostic Factors in Primary Large-Cell Lymphoma of the Testis in a Survey by the International Extranodal Lymphoma Study Group by ZUCCA, E, CONCONI, A, CORTELAZZO, S, FERRERI, A. J. M, AMBROSETTI, A, MARTELLI, M, THIEBLEMONT, C, GOMEZ MORENO, H, PINOTTI, G, MARTINELLI, G, MOZZANA, R, GRISANTI, S, MUGHAL, T. I, PROVENCIO, M, BALZAROTTI, M, LAVEDER, F, OLTEAN, G, CALLED, V, ROY, P, CAVALLI, F, GOSPODAROWICZ, M. K, SARRIS, A. H, SEYMOUR, J. F, VITOLO, U, KLASA, R, OZSAHIN, M, MEAD, G. M, GIANNI, M. A

“…To determine clinical features and patterns of outcome of primary testicular diffuse large B-cell lymphomas (DLCL). A retrospective international survey of 373…”
Get full text

A phase II study of bortezomib in mantle cell lymphoma: the National Cancer Institute of Canada Clinical Trials Group trial IND.150 by Belch, A., Kouroukis, C.T., Crump, M., Sehn, L., Gascoyne, R.D., Klasa, R., Powers, J., Wright, J., Eisenhauer, E.A.

“…Background: We evaluated the activity and toxic effects of bortezomib in patients with mantle cell lymphoma. Patients and methods: Thirty patients, including…”
Get full text

Mantle cell lymphoma : A clinicopathologic study of 80 cases by ARGATOFF, L. H, CONNORS, J. M, KLASA, R. J, HORSMAN, D. E, GASCOYNE, R. D

“…Mantle cell lymphoma (MCL) is a relatively uncommon yet distinct type of malignant lymphoma whose clinical and pathological characterization has been limited…”
Get full text

Hodgkin’s lymphoma in Chinese migrants to British Columbia: a 25-year survey by Au, W. Y., Gascoyne, R. D., Gallagher, R. E., Le, N., Klasa, R. D., Liang, R. H. S., Choy, C., Foo, W., Connors, J. M.

“…Background: Compared with the West, Hodgkin’s lymphoma in Oriental countries is characterized by a lower incidence rate and a higher proportion of mixed…”
Get full text

Incidence and spectrum of non‐Hodgkin lymphoma in Chinese migrants to British Columbia by Au, W.Y., Gascoyne, R.D., Klasa, R.D., Connors, J.M., Gallagher, R.P., Le, N.D., Loong, F., Law, C.K., Liang, R.

“…Summary The incidence and spectrum of non‐Hodgkin lymphoma (NHL) differ between the Chinese and Caucasian populations. Using population‐based registries, we…”
Get full text

Limited-stage mantle-cell lymphoma by Leitch, H. A., Gascoyne, R. D., Chhanabhai, M., Voss, N. J., Klasa, R., Connors, J. M.

“…Background: Mantle-cell lymphoma (MCL) is known to have a poor outcome, however, most patients present with advanced-stage disease. Little information is…”
Get full text

Eradication of Human Non-Hodgkin’s Lymphoma in SCID Mice by BCL-2 Antisense Oligonucleotides Combined with Low-Dose Cyclophosphamide by KLASA, R. J, BALLY, M. B, NG, R, GOLDIE, J. H, GASCOYNE, R. D, WONG, F. M. P

“…Cancers overexpressing Bcl-2 protein, which prevents programmed cell death (apoptosis), are less sensitive to stresses that produce cellular damage, including…”
Get full text

Concurrent translocation of BCL2 and MYC with a single immunoglobulin locus in high-grade B-cell lymphomas by KNEZEVICH, S, LUDKOVSKI, O, HORSMAN, D. E, SALSKI, C, LESTOU, V, CHHANABHAI, M, LAM, W, KLASA, R, CONNORS, J. M, DYER, M. J. S, GASCOYNE, R. D

“…B-cell leukaemia or lymphoma with a combination of t(8;14)(q24;q32) of Burkitt leukaemia/lymphoma and t(14;18)(q32;q21) of follicular lymphoma may present…”
Get full text

Second Malignancies in Patients With Hairy Cell Leukemia in British Columbia: A 20-Year Experience by Au, Wing Y., Klasa, Richard J., Gallagher, Richard, Le, Nhu, Gascoyne, Randy D., Connors, Joseph M.

“…The purpose of this study was to compare the relative risk of second malignancies in a cohort of patients with hairy cell leukemia (HCL) against the normal…”
Get full text

Development and assessment of conventional and targeted drug combinations for use in the treatment of aggressive breast cancers by Waterhouse, D N, Gelmon, K A, Klasa, R, Chi, K, Huntsman, D, Ramsay, E, Wasan, E, Edwards, L, Tucker, C, Zastre, J, Wang, Y Z, Zhang, Y Z, Yapp, D, Dragowska, W, Dunn, S, Dedhar, S, Bally, M B

“…Combination chemotherapy has been at the forefront of cancer treatment for over 40 years. However, the rationale for selecting drug combinations and the…”
Get more information

High-Dose Cyclophosphamide, Carmustine (BCNU), and Etoposide (VP16-213) With or Without Cisplatin (CBV ± P) and Autologous Transplantation for Patients With Hodgkin's Disease Who Fail to Enter a Complete Remission After Combination Chemotherapy by Reece, D.E., Barnett, M.J., Shepherd, J.D., Hogge, D.E., Klasa, R.J., Nantel, S.H., Sutherland, H.J., Klingemann, H.G., Fairey, R.N., Voss, N.J., Connors, J.M., O'Reilly, S.E., Spinelli, J.J., Phillips, G.L

“…Patients with Hodgkin's disease (HD) who fail to enter a complete remission after an initial course of combination chemotherapy are usually considered to have…”
Get full text

8q24 translocations in blastic transformation of mantle cell lymphoma by AU, Wing Y, HORSMAN, Douglas E, VISWANATHA, David S, CONNORS, Joseph M, KLASA, Richard J, GASCOYNE, Randy D

Get full text

Incidence of second neoplasms in patients with MALT lymphoma: No increase in risk above the background population by Au, W. Y., Gascoyne, R. D., Le, N., Viswanatha, D. S., Klasa, R. J., Gallagher, R., Connors, J. M.

“…Background: Lymphomas of mucosa associated lymphoid tissue (MALT) are a special type of extranodal lymphoma, possibly related to chronic antigenic stimulation…”
Get full text

Bcl-3/IgH translocation (14;19)(q32;q13) in Non-Hodgkin's Lymphomas by Au, W.Y., Horsman, D.E., Ohno, H., Klasa, R.J., Gascoyne, R.D.

“…The recurrent cytogenetic (CG) abnormality t(14;19)(q32;q13) involving the oncogene BCL3 is described in patients with atypical chronic lymphocytic leukemia…”
Get full text

Dose-intensity meta-analysis of chemotherapy regimens in small-cell carcinoma of the lung by Klasa, R J, Murray, N, Coldman, A J

“…To determine if chemotherapy dose intensity (DI) influences treatment outcome, 60 published studies in limited- and extensive-stage small-cell carcinoma of the…”
Get more information

In search of an optimal regimen for elderly patients with advanced-stage diffuse large-cell lymphoma: results of a phase II study of P/DOCE chemotherapy by O'Reilly, S E, Connors, J M, Howdle, S, Hoskins, P, Klasa, R, Klimo, P, Stuart, D S

“…The results of a prospective, phase II trial of an 8-week treatment program consisting of epirubicin or doxorubicin, vincristine, cyclophosphamide, etoposide,…”
Get more information

Rational approaches to design of therapeutics targeting molecular markers by Klasa, R J, List, A F, Cheson, B D

“…This paper introduces novel therapeutic strategies focusing on a molecular marker relevant to a particular hematologic malignancy. Four different approaches…”
Get full text

Concurrent chromosomal alterations at 3q27, 8q24 and 18q21 in B-cell lymphomas by AU, W. Y, GASCOYNE, R. D, VISWANATHA, D. S, SKINNIDER, B. F, CONNORS, J. M, KLASA, R. J, HORSMAN, D. E

“…Recurrent chromosomal translocations in malignant lymphomas most commonly involve 18q21(bcl-2), 8q24 (c-myc) and 3q27 (bcl-6), with an incidence of 27%, 11%…”
Get full text