Search Results - "KLARESKOG, L"

The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritis by Klareskog, L., Rönnelid, J., Saevarsdottir, S., Padyukov, L., Alfredsson, L.

“…The current review uses rheumatoid arthritis (RA) as a prominent example for how studies on the interplay between environmental and genetic factors in defined…”
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Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets by Zhao, Jing Hua, Stacey, David, Eriksson, Niclas, Macdonald-Dunlop, Erin, Hedman, Åsa K., Kalnapenkis, Anette, Enroth, Stefan, Cozzetto, Domenico, Digby-Bell, Jonathan, Marten, Jonathan, Folkersen, Lasse, Herder, Christian, Jonsson, Lina, Bergen, Sarah E., Gieger, Christian, Needham, Elise J., Surendran, Praveen, Paul, Dirk S., Polasek, Ozren, Thorand, Barbara, Grallert, Harald, Roden, Michael, Võsa, Urmo, Esko, Tonu, Hayward, Caroline, Johansson, Åsa, Gyllensten, Ulf, Powell, Nick, Hansson, Oskar, Mattsson-Carlgren, Niklas, Joshi, Peter K., Danesh, John, Padyukov, Leonid, Klareskog, Lars, Landén, Mikael, Wilson, James F., Siegbahn, Agneta, Wallentin, Lars, Mälarstig, Anders, Butterworth, Adam S., Peters, James E.

“…Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins,…”
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A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis by Padyukov, Leonid, Seielstad, Mark, Ong, Rick T H, Ding, Bo, Rönnelid, Johan, Seddighzadeh, Maria, Alfredsson, Lars, Klareskog, Lars

“…Rheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA). Until…”
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Rapid increase in myocardial infarction risk following diagnosis of rheumatoid arthritis amongst patients diagnosed between 1995 and 2006 by Holmqvist, M. E., Wedrén, S., Jacobsson, L. T. H., Klareskog, L., Nyberg, F., Rantapää‐Dahlqvist, S., Alfredsson, L., Askling, J.

“…  Holmqvist ME, Wedrén S, Jacobsson LTH, Klareskog L, Nyberg F, Rantapää‐Dahlqvist S, Alfredsson L, Askling J (Institute of Environmental Medicine, Karolinska…”
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Tumor necrosis factor antagonist mechanisms of action: a comprehensive review by Tracey, Daniel, Klareskog, Lars, Sasso, Eric H, Salfeld, Jochen G, Tak, Paul P

“…During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's disease, psoriasis, psoriatic arthritis and ankylosing spondylitis…”
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Features of the Synovium of Individuals at Risk of Developing Rheumatoid Arthritis: Implications for Understanding Preclinical Rheumatoid Arthritis by Hair, M. J. H., Sande, M. G. H., Ramwadhdoebe, T. H., Hansson, M., Landewé, R., Leij, C., Maas, M., Serre, G., Schaardenburg, D., Klareskog, L., Gerlag, D. M., Baarsen, L. G. M., Tak, P. P.

“…Objective Findings from previous studies have suggested that subclinical inflammation of the synovium does not coincide with the appearance of rheumatoid…”
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EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT) by Combe, B, Landewe, R, Lukas, C, Bolosiu, H D, Breedveld, F, Dougados, M, Emery, P, Ferraccioli, G, Hazes, J M W, Klareskog, L, Machold, K, Martin-Mola, E, Nielsen, H, Silman, A, Smolen, J, Yazici, H

“…Objective: To formulate EULAR recommendations for the management of early arthritis. Methods: In accordance with EULAR’s “standardised operating procedures”,…”
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Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism by Wigerblad, Gustaf, Bas, Duygu B, Fernades-Cerqueira, Cátia, Krishnamurthy, Akilan, Nandakumar, Kutty Selva, Rogoz, Katarzyna, Kato, Jungo, Sandor, Katalin, Su, Jie, Jimenez-Andrade, Juan Miguel, Finn, Anja, Bersellini Farinotti, Alex, Amara, Khaled, Lundberg, Karin, Holmdahl, Rikard, Jakobsson, Per-Johan, Malmström, Vivianne, Catrina, Anca I, Klareskog, Lars, Svensson, Camilla I

“…An interesting and so far unexplained feature of chronic pain in autoimmune disease is the frequent disconnect between pain and inflammation. This is…”
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Animal models for arthritis: innovative tools for prevention and treatment by Kollias, George, Papadaki, Piyi, Apparailly, Florence, Vervoordeldonk, Margriet J, Holmdahl, Rikard, Baumans, Vera, Desaintes, Christian, Di Santo, James, Distler, Jörg, Garside, Paul, Hegen, Martin, Huizinga, Tom W J, Jüngel, Astrid, Klareskog, Lars, McInnes, Iain, Ragoussis, Ioannis, Schett, Georg, Hart, Bert 't, Tak, Paul P, Toes, Rene, van den Berg, Wim, Wurst, Wolfgang, Gay, Steffen

“…The development of novel treatments for rheumatoid arthritis (RA) requires the interplay between clinical observations and studies in animal models. Given the…”
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Features of the Synovium of Individuals at Risk of Developing Rheumatoid Arthritis by de, Hair MJH, van, de Sande MGH, Ramwadhdoebe, TH, Hansson, M, Landewe, R, van, der Leij C, Maas, M, Serre, G, van, Schaardenburg D, Klareskog, L

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Respiratory Diseases as Risk Factors for Seropositive and Seronegative Rheumatoid Arthritis and in Relation to Smoking by Kronzer, Vanessa L., Westerlind, Helga, Alfredsson, Lars, Crowson, Cynthia S., Nyberg, Fredrik, Tornling, Göran, Klareskog, Lars, Holmqvist, Marie, Askling, Johan

“…Objective The link and interplay between different airway exposures and rheumatoid arthritis (RA) risk are unclear. This study was undertaken to determine…”
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Citrullination is an inflammation-dependent process by Makrygiannakis, D, af Klint, E, Lundberg, I E, Löfberg, R, Ulfgren, A-K, Klareskog, L, Catrina, A I

“…Objectives: To study the presence of citrullinated proteins in inflammatory conditions and in clinically non-affected tissues of controls. Methods: Synovial…”
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The impact of immunomodulating treatment on the immunogenicity of COVID-19 vaccines in patients with immune-mediated inflammatory rheumatic diseases compared to healthy controls. A Swedish nationwide study (COVID19-REUMA) by Frodlund, Martina, Nived, Per, Chatzidionysiou, Aikaterini, Södergren, Anna, Klingberg, Eva, Bengtsson, Anders, Hansson, Monika, Olsson, Sophie, Pin, Elisa, Klareskog, Lars, Kapetanovic, Meliha C

“…To elucidate antibody responses after the second and third dose of COVID-19 vaccine in patients with inflammatory rheumatic diseases (IRD) treated with…”
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European biologicals registers: methodology, selected results and perspectives by Zink, A, Askling, J, Dixon, W G, Klareskog, L, Silman, A J, Symmons, D P M

“…With the licensing of the first tumour necrosis factor (TNF)alpha inhibitors, independent academia-initiated but industry-sponsored drug registers were set up…”
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Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases by Stolt, P, Bengtsson, C, Nordmark, B, Lindblad, S, Lundberg, I, Klareskog, L, Alfredsson, L

“…Objective: To quantify the influence of cigarette smoking on the risk of developing rheumatoid arthritis (RA). Methods: 679 cases and 847 controls included…”
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Widespread non-joint pain in early rheumatoid arthritis by Schelin, MEC, Westerlind, H, Lindqvist, J, Englid, E, Israelsson, L, Skillgate, E, Klareskog, L, Alfredsson, L, Lampa, J

“…Objective: The aim of the study was to assess the development of widespread non-joint pain (WNP) in a cohort of patients with early rheumatoid arthritis (RA),…”
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Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial by Klareskog, Lars, van der Heijde, Désirée, de Jager, Julien P, Gough, Andrew, Kalden, Joachim, Malaise, Michel, Mola, Emilio Martín, Pavelka, Karel, Sany, Jacques, Settas, Lucas, Wajdula, Joseph, Pedersen, Ronald, Fatenejad, Saeed, Sanda, Marie

“…Etanercept and methotrexate are effective in the treatment of rheumatoid arthritis but no data exist on concurrent initiation or use of the combination…”
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Local anti-inflammatory combination treatment of experimental oa based on injectable gels by Aulin, C., Palmblad, K., Klareskog, L., Harris, H.E.

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Genome-wide investigation of persistence with methotrexate treatment in early rheumatoid arthritis by Sysojev, Anton Öberg, Saevarsdottir, Saedis, Diaz-Gallo, Lina-Marcela, Silberberg, Gilad N, Alfredsson, Lars, Klareskog, Lars, Baecklund, Eva, Björkman, Lena, Kastbom, Alf, Rantapää-Dahlqvist, Solbritt, Turesson, Carl, Jonsdottir, Ingileif, Stefansson, Kari, Frisell, Thomas, Padyukov, Leonid, Askling, Johan, Westerlind, Helga

“…To investigate the influence of genetic factors on persistence with treatment of early RA with MTX monotherapy. We conducted a genome-wide association study…”
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Smoking and alcohol associated to the risk of developing Myasthenia gravis in a Swedish nationwide prevalent cohort by Petersson, M., Jons, D., Feresiadou, A., Ilinca, A., Lundin, F., Johansson, R., Budzianowska, A., Roos, A., Kågström, V., Gunnarsson, Martin, Sundström, P., Klareskog, L., Olsson, T., Kockum, I., Piehl, F., Alfredsson, L., Brauner, S.

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