Search Results - "KLAPPER, Simon"

Astrocyte lineage cells are essential for functional neuronal differentiation and synapse maturation in human iPSC‐derived neural networks by Klapper, Simon D., Garg, Pretty, Dagar, Sushma, Lenk, Kerstin, Gottmann, Kurt, Nieweg, Katja

“…Human astrocytes differ dramatically in cell morphology and gene expression from murine astrocytes. The latter are well known to be of major importance in the…”
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Vision Restoration Becomes Druggable by Klapper, Simon Darius, Busskamp, Volker

“…In this issue of Neuron, Tochitsky et al. (2016) have identified the mechanism by which small-molecule photoswitches enter and specifically activate retinal…”
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Optogenetic Stimulation of Human Neural Networks Using Fast Ferroelectric Spatial Light Modulator—Based Holographic Illumination by Schmieder, Felix, Klapper, Simon, Koukourakis, Nektarios, Busskamp, Volker, Czarske, Jürgen

“…The generation and application of human stem-cell-derived functional neural circuits promises novel insights into neurodegenerative diseases. These networks…”
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Biophysical Properties of Optogenetic Tools and Their Application for Vision Restoration Approaches by Klapper, Simon D, Swiersy, Anka, Bamberg, Ernst, Busskamp, Volker

“…Optogenetics is the use of genetically encoded light-activated proteins to manipulate cells in a minimally invasive way using light. The most prominent example…”
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On-demand optogenetic activation of human stem-cell-derived neurons by Klapper, Simon D., Sauter, Evelyn J., Swiersy, Anka, Hyman, Max A. E., Bamann, Christian, Bamberg, Ernst, Busskamp, Volker

“…The widespread application of human stem-cell-derived neurons for functional studies is impeded by complicated differentiation protocols, immaturity, and…”
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C-terminal fragment of N-cadherin accelerates synapse destabilization by amyloid-β by ANDREYEVA, Aksana, NIEWEG, Katja, HORSTMANN, Katharina, KLAPPER, Simon, MÜLLER-SCHIFFMANN, Andreas, KORTH, Carsten, GOTTMANN, Kurt

“…The aetiology of Alzheimer's disease is thought to include functional impairment of synapses and synapse loss as crucial pathological events leading to…”
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