Search Results - "KJAER, Svend"

Isoform diversity in the Arp2/3 complex determines actin filament dynamics by Abella, Jasmine V. G., Galloni, Chiara, Pernier, Julien, Barry, David J., Kjær, Svend, Carlier, Marie-France, Way, Michael

“…The Arp2/3 complex consists of seven evolutionarily conserved subunits (Arp2, Arp3 and ARPC1–5) and plays an essential role in generating branched actin…”
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The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in mammalian cells by van der Veen, Annemarthe G, Maillard, Pierre V, Schmidt, Jan Marten, Lee, Sonia A, Deddouche‐Grass, Safia, Borg, Annabel, Kjær, Svend, Snijders, Ambrosius P, Reis e Sousa, Caetano

“…In vertebrates, the presence of viral RNA in the cytosol is sensed by members of the RIG‐I‐like receptor (RLR) family, which signal to induce production of…”
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SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies by Ng, Kevin W, Faulkner, Nikhil, Finsterbusch, Katja, Wu, Mary, Harvey, Ruth, Hussain, Saira, Greco, Maria, Liu, Yafei, Kjaer, Svend, Swanton, Charles, Gandhi, Sonia, Beale, Rupert, Gamblin, Steve J, Cherepanov, Peter, McCauley, John, Daniels, Rodney, Howell, Michael, Arase, Hisashi, Wack, Andreas, Bauer, David L V, Kassiotis, George

“…Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged during the current coronavirus disease 2019 (COVID-19) pandemic…”
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Mechanism of chaperone coordination during cotranslational protein folding in bacteria by Roeselová, Alžběta, Maslen, Sarah L, Shivakumaraswamy, Santosh, Pellowe, Grant A, Howell, Steven, Joshi, Dhira, Redmond, Joanna, Kjær, Svend, Skehel, J Mark, Balchin, David

“…Protein folding is assisted by molecular chaperones that bind nascent polypeptides during mRNA translation. Several structurally distinct classes of chaperones…”
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VE-Cadherin–Mediated Epigenetic Regulation of Endothelial Gene Expression by Morini, Marco F, Giampietro, Costanza, Corada, Monica, Pisati, Federica, Lavarone, Elisa, Cunha, Sara I, Conze, Lei L, O’Reilly, Nicola, Joshi, Dhira, Kjaer, Svend, George, Roger, Nye, Emma, Ma, Anqi, Jin, Jian, Mitter, Richard, Lupia, Michela, Cavallaro, Ugo, Pasini, Diego, Calado, Dinis P, Dejana, Elisabetta, Taddei, Andrea

“…RATIONALE:The mechanistic foundation of vascular maturation is still largely unknown. Several human pathologies are characterized by deregulated angiogenesis…”
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Resolving chaperone-assisted protein folding on the ribosome at the peptide level by Wales, Thomas E, Pajak, Aleksandra, Roeselová, Alžběta, Shivakumaraswamy, Santosh, Howell, Steven, Kjær, Svend, Hartl, F Ulrich, Engen, John R, Balchin, David

“…Protein folding in vivo begins during synthesis on the ribosome and is modulated by molecular chaperones that engage the nascent polypeptide. How these…”
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A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion by Zhang, Leran, Lovell, Scott, De Vita, Elena, Jagtap, Pravin Kumar Ankush, Lucy, Daniel, Goya Grocin, Andrea, Kjær, Svend, Borg, Annabel, Hennig, Janosch, Miller, Aubry K., Tate, Edward W.

“…Pancreatic cancer has the lowest survival rate of all common cancers due to late diagnosis and limited treatment options. Serine hydrolases are known to…”
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MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes by Galloni, Chiara, Carra, Davide, Abella, Jasmine V G, Kjær, Svend, Singaravelu, Pavithra, Barry, David J, Kogata, Naoko, Guérin, Christophe, Blanchoin, Laurent, Way, Michael

“…The mechanisms regulating the disassembly of branched actin networks formed by the Arp2/3 complex still remain to be fully elucidated. In addition, the impact…”
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PINK1 cleavage at position A103 by the mitochondrial protease PARL by DEAS, Emma, PLUN-FAVREAU, Helene, ABRAMOV, Andrey Y, WOOD, Nicholas W, GANDHI, Sonia, DESMOND, Howard, KJAER, Svend, LOH, Samantha H. Y, RENTON, Alan E. M, HARVEY, Robert J, WHITWORTH, Alexander J, MARTINS, L. Miguel

“…Mutations in PTEN-induced kinase 1 (PINK1) cause early onset autosomal recessive Parkinson's disease (PD). PINK1 is a 63 kDa protein kinase, which exerts a…”
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The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition by Kelly, Joanna R., Martini, Silvia, Brownlow, Nicola, Joshi, Dhira, Federico, Stefania, Jamshidi, Shirin, Kjaer, Svend, Lockwood, Nicola, Rahman, Khondaker Miraz, Fraternali, Franca, Parker, Peter J., Soliman, Tanya N.

“…The Aurora B abscission checkpoint delays cytokinesis until resolution of DNA trapped in the cleavage furrow. This process involves PKCε phosphorylation of…”
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A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells by Hanč, Pavel, Schulz, Oliver, Fischbach, Hanna, Martin, Stephen R, Kjær, Svend, Reis e Sousa, Caetano

“…DNGR‐1 is receptor expressed by certain dendritic cell (DC) subsets and by DC precursors in mouse. It possesses a C‐type lectin‐like domain (CTLD) followed by…”
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Cysteine-Reactive Free ISG15 Generates IL-1β-Producing CD8α + Dendritic Cells at the Site of Infection by Napolitano, Anna, van der Veen, Annemarthe G, Bunyan, Monique, Borg, Annabel, Frith, David, Howell, Steven, Kjaer, Svend, Beling, Antje, Snijders, Ambrosius P, Knobeloch, Klaus-Peter, Frickel, Eva-Maria

“…IFN-stimulated gene (ISG) 15 is a ubiquitin-like protein induced after type I IFN stimulation. There is a dearth of in vivo models to study free unconjugated…”
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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1 by Martins, L. Miguel, Downward, Julian, Plun-Favreau, Hélène, Klupsch, Kristina, Moisoi, Nicoleta, Gandhi, Sonia, Kjaer, Svend, Frith, David, Harvey, Kirsten, Deas, Emma, Harvey, Robert J, McDonald, Neil, Wood, Nicholas W

“…In mice, targeted deletion of the serine protease HtrA2 (also known as Omi) causes mitochondrial dysfunction leading to a neurodegenerative disorder with…”
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Author Correction: The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition by Kelly, Joanna R., Martini, Silvia, Brownlow, Nicola, Joshi, Dhira, Federico, Stefania, Jamshidi, Shirin, Kjaer, Svend, Lockwood, Nicola, Rahman, Khondaker Miraz, Fraternali, Franca, Parker, Peter J., Soliman, Tanya N.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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5‑Phenyl-1,3,4-oxadiazol-2(3H)‑ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit by Mahy, William, Willis, Nicky J, Zhao, Yuguang, Woodward, Hannah L, Svensson, Fredrik, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R, Hillier, James, Kjær, Svend, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Salinas, Patricia C, Whiting, Paul, Vincent, Jean-Paul, Jones, E. Yvonne, Fish, Paul V

“…Carboxylesterase Notum is a negative regulator of the Wnt signaling pathway. There is an emerging understanding of the role Notum plays in disease, supporting…”
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Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit by Willis, Nicky J., Mahy, William, Sipthorp, James, Zhao, Yuguang, Woodward, Hannah L., Atkinson, Benjamin N., Bayle, Elliott D., Svensson, Fredrik, Frew, Sarah, Jeganathan, Fiona, Monaghan, Amy, Benvegnù, Stefano, Jolly, Sarah, Vecchia, Luca, Ruza, Reinis R., Kjær, Svend, Howell, Steven, Snijders, Ambrosius P., Bictash, Magda, Salinas, Patricia C., Vincent, Jean-Paul, Jones, E. Yvonne, Whiting, Paul, Fish, Paul V.

“…Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing…”
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14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins by Riou, Philippe, Kjær, Svend, Garg, Ritu, Purkiss, Andrew, George, Roger, Cain, Robert J., Bineva, Ganka, Reymond, Nicolas, McColl, Brad, Thompson, Andrew J., O’Reilly, Nicola, McDonald, Neil Q., Parker, Peter J., Ridley, Anne J.

“…Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI…”
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Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains by Faulkner, Nikhil, Ng, Kevin W, Wu, Mary Y, Harvey, Ruth, Margaritis, Marios, Paraskevopoulou, Stavroula, Houlihan, Catherine, Hussain, Saira, Greco, Maria, Bolland, William, Warchal, Scott, Heaney, Judith, Rickman, Hannah, Spyer, Moria, Frampton, Daniel, Byott, Matthew, de Oliveira, Tulio, Sigal, Alex, Kjaer, Svend, Swanton, Charles, Gandhi, Sonia, Beale, Rupert, Gamblin, Steve J, McCauley, John W, Daniels, Rodney Stuart, Howell, Michael, Bauer, David, Nastouli, Eleni, Kassiotis, George

“…Background: The degree of heterotypic immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is a major determinant of the…”
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Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations by McDonald, Neil Q, Kjær, Svend, Hanrahan, Sarah, Totty, Nick

“…RET tyrosine kinase is essential for various developmental processes, and loss-of-function ret missense mutations cause Hirschsprung's disease (HSCR)…”
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A small molecule inhibitor of HER3: a proof-of-concept study by Colomba, Audrey, Fitzek, Martina, George, Roger, Weitsman, Gregory, Roberts, Selene, Zanetti-Domingues, Laura, Hirsch, Michael, Rolfe, Daniel J, Mehmood, Shahid, Madin, Andrew, Claus, Jeroen, Kjaer, Svend, Snijders, Ambrosius P, Ng, Tony, Martin-Fernandez, Marisa, Smith, David M, Parker, Peter J

“…Despite being catalytically defective, pseudokinases are typically essential players of cellular signalling, acting as allosteric regulators of their active…”
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