Search Results - "KIYOI, H"

High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG by Sakura, T, Hayakawa, F, Sugiura, I, Murayama, T, Imai, K, Usui, N, Fujisawa, S, Yamauchi, T, Yujiri, T, Kakihana, K, Ito, Y, Kanamori, H, Ueda, Y, Miyata, Y, Kurokawa, M, Asou, N, Ohnishi, K, Ohtake, S, Kobayashi, Y, Matsuo, K, Kiyoi, H, Miyazaki, Y, Naoe, T

“…High-dose methotrexate (Hd-MTX) therapy has recently been applied to the treatment of adult acute lymphoblastic leukemia (ALL) based on pediatric protocols;…”
Get full text

Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients by Kihara, R, Nagata, Y, Kiyoi, H, Kato, T, Yamamoto, E, Suzuki, K, Chen, F, Asou, N, Ohtake, S, Miyawaki, S, Miyazaki, Y, Sakura, T, Ozawa, Y, Usui, N, Kanamori, H, Kiguchi, T, Imai, K, Uike, N, Kimura, F, Kitamura, K, Nakaseko, C, Onizuka, M, Takeshita, A, Ishida, F, Suzushima, H, Kato, Y, Miwa, H, Shiraishi, Y, Chiba, K, Tanaka, H, Miyano, S, Ogawa, S, Naoe, T

“…To clarify the cooperative roles of recurrently identified mutations and to establish a more precise risk classification system in acute myeloid leukemia…”
Get full text

Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis by YANADA, M, MATSUO, K, SUZUKI, T, KIYOI, H, NAOE, T

“…Two distinct forms of fms-like tyrosine kinase (FLT3) gene aberrations, internal tandem duplication (ITD) and tyrosine kinase domain (TKD) mutations, have been…”
Get full text

Array-based genomic resequencing of human leukemia by Yamashita, Y, Yuan, J, Suetake, I, Suzuki, H, Ishikawa, Y, Choi, Y L, Ueno, T, Soda, M, Hamada, T, Haruta, H, Takada, S, Miyazaki, Y, Kiyoi, H, Ito, E, Naoe, T, Tomonaga, M, Toyota, M, Tajima, S, Iwama, A, Mano, H

“…To identify oncogenes in leukemias, we performed large-scale resequencing of the leukemia genome using DNA sequence arrays that determine ∼9 Mbp of sequence…”
Get full text

JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults by Kiyoi, H, Yamaji, S, Kojima, S, Naoe, T

Get full text

Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia by Togasaki, E, Takeda, J, Yoshida, K, Shiozawa, Y, Takeuchi, M, Oshima, M, Saraya, A, Iwama, A, Yokote, K, Sakaida, E, Hirase, C, Takeshita, A, Imai, K, Okumura, H, Morishita, Y, Usui, N, Takahashi, N, Fujisawa, S, Shiraishi, Y, Chiba, K, Tanaka, H, Kiyoi, H, Ohnishi, K, Ohtake, S, Asou, N, Kobayashi, Y, Miyazaki, Y, Miyano, S, Ogawa, S, Matsumura, I, Nakaseko, C, Naoe, T

“…Although tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of chronic myeloid leukemia (CML), the ability of TKIs to eradicate CML…”
Get full text

Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation by Yasuda, T, Ueno, T, Fukumura, K, Yamato, A, Ando, M, Yamaguchi, H, Soda, M, Kawazu, M, Sai, E, Yamashita, Y, Murata, M, Kiyoi, H, Naoe, T, Mano, H

Get full text

Somatic PHF6 mutations in 1760 cases with various myeloid neoplasms by Mori, T, Nagata, Y, Makishima, H, Sanada, M, Shiozawa, Y, Kon, A, Yoshizato, T, Sato-Otsubo, A, Kataoka, K, Shiraishi, Y, Chiba, K, Tanaka, H, Ishiyama, K, Miyawaki, S, Mori, H, Nakamaki, T, Kihara, R, Kiyoi, H, Koeffler, H P, Shih, L-Y, Miyano, S, Naoe, T, Haferlach, C, Kern, W, Haferlach, T, Ogawa, S, Yoshida, K

Get full text

Retrospective analysis of in vivo recovery and clearance during continuous infusion of recombinant factor VIII products: a single‐institution study by Suzuki, N., Hirakawa, A., Kishimoto, M., Kanematsu, T., Ogawa, M., Kiyoi, H., Matsushita, T.

“…Background Continuous infusion (CI) of recombinant FVIII (rFVIII) concentrates has been reported as an effective and safe method to achieve haemostasis during…”
Get full text

Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma by Shimada, K, Shimada, S, Sugimoto, K, Nakatochi, M, Suguro, M, Hirakawa, A, Hocking, T D, Takeuchi, I, Tokunaga, T, Takagi, Y, Sakamoto, A, Aoki, T, Naoe, T, Nakamura, S, Hayakawa, F, Seto, M, Tomita, A, Kiyoi, H

“…Intravascular large B-cell lymphoma (IVLBCL) is a distinct disease entity with the peculiar characteristic that tumor cells proliferate within vessels. Despite…”
Get full text

Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice by NINOMIYA, M, ABE, A, NAOE, T, KATSUMI, A, XU, J, ITO, M, ARAI, F, SUDA, T, ITO, M, KIYOI, H, KINOSHITA, T

“…The cellular components of the hematopoietic stem cell niche have been gradually identified. However, the niche for malignant hematopoiesis remains to be…”
Get full text

High-dose chemotherapy followed by autologous stem cell transplantation for relapsed/refractory primary mediastinal large B-cell lymphoma by Aoki, T, Shimada, K, Suzuki, R, Izutsu, K, Tomita, A, Maeda, Y, Takizawa, J, Mitani, K, Igarashi, T, Sakai, K, Miyazaki, K, Mihara, K, Ohmachi, K, Nakamura, N, Takasaki, H, Kiyoi, H, Nakamura, S, Kinoshita, T, Ogura, M

Get full text

Normal and oncogenic FLT3 by Naoe, T, Kiyoi, H

“…FLT3, a member of the class III receptor tyrosine kinases (RTKs), is preferentially expressed on the cell surface of hematopoietic progenitors, and the ligand…”
Get full text

FIVE‐YEAR RESULTS OF A PHASE 2 STUDY OF CNS‐ORIENTED THERAPY WITH R‐CHOP FOR UNTREATED INTRAVASCULAR LARGE B‐CELL LYMPHOMA: FINAL ANALYSIS OF THE PRIMEUR‐IVL STUDY by Shimada, K., Yamaguchi, M., Kuwatsuka, Y., Matsue, K., Sato, K., Kusumoto, S., Nagai, H., Takizawa, J., Fukuhara, N., Nagafuji, K., Miyazaki, K., Ohtsuka, E., Okamoto, A., Uchida, T., Kayukawa, S., Wake, A., Sugita, Y., Ennishi, D., Kondo, Y., Meguro, A., Kin, Y., Minami, Y., Hashimoto, D., Nishiyama, T., Shimada, S., Masaki, Y., Okamoto, M., Atsuta, Y., Kiyoi, H., Suzuki, R., Nakamura, S., Kinoshita, T.

Get full text

Integration of humoral and cellular HLA-specific immune responses in cord blood allograft rejection by Hanajiri, R, Murata, M, Sugimoto, K, Murase, M, Sakemura, R, Goto, T, Watanabe, K, Imahashi, N, Terakura, S, Ohashi, H, Akatsuka, Y, Kurahashi, S, Miyamura, K, Kiyoi, H, Nishida, T, Naoe, T

“…In allo-stem cell transplantation (SCT), it is unclear whether donor-specific anti-HLA Abs (DSAs) can actually mediate graft rejection or if they are simply…”
Get full text

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies by Yamamoto, Yukiya, Kiyoi, Hitoshi, Nakano, Yasuyuki, Suzuki, Ritsuro, Kodera, Yoshihisa, Miyawaki, Shuichi, Asou, Norio, Kuriyama, Kazutaka, Yagasaki, Fumiharu, Shimazaki, Chihiro, Akiyama, Hideki, Saito, Kenji, Nishimura, Miki, Motoji, Toshiko, Shinagawa, Katsuji, Takeshita, Akihiro, Saito, Hidehiko, Ueda, Ryuzo, Ohno, Ryuzo, Naoe, Tomoki

“…Mutations of receptor tyrosine kinases are implicated in the constitutive activation and development of human malignancy. An internal tandem duplication (ITD)…”
Get full text

Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group by Hayakawa, F, Sakura, T, Yujiri, T, Kondo, E, Fujimaki, K, Sasaki, O, Miyatake, J, Handa, H, Ueda, Y, Aoyama, Y, Takada, S, Tanaka, Y, Usui, N, Miyawaki, S, Suenobu, S, Horibe, K, Kiyoi, H, Ohnishi, K, Miyazaki, Y, Ohtake, S, Kobayashi, Y, Matsuo, K, Naoe, T

“…The superiority of the pediatric protocol for adolescents with acute lymphoblastic leukemia (ALL) has already been demonstrated, however, its efficacy in young…”
Get full text

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product by KIYOI, H, TOWATARI, M, YOKOTA, S, HAMAGUCHI, M, OHNO, R, SAITO, H, NAOE, T

“…An internal tandem duplication (ITD) of the FLT3 gene is found in nearly 20% of acute myeloid leukemia (AML) and 5% of myelodysplastic syndrome cases. Our…”
Get full text

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines by YOKOTA, S, KIYOI, H, NAOE, T, NAKAO, M, IWAI, T, MISAWA, S, OKUDA, T, SONODA, Y, ABE, T, KAHSIMA, K, MATSUO, Y

“…In this study, we examined a large number of patients to clarify the distribution and frequency of a recently described FLT3 tandem duplication among…”
Get full text

Impact of T-cell chimerism on relapse after cord blood transplantation for hematological malignancies: Nagoya Blood and Marrow Transplantation Group study by Yokohata, E, Kuwatsuka, Y, Ohashi, H, Terakura, S, Kawashima, N, Seto, A, Kurahashi, S, Ozawa, Y, Goto, T, Imahashi, N, Nishida, T, Miyao, K, Sakemura, R, Kato, T, Sawa, M, Kohno, A, Sao, H, Iida, H, Kiyoi, H, Naoe, T, Miyamura, K, Murata, M

Get full text