Search Results - "KIYAMA, Hiroshi"

Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases by Konishi, Hiroyuki, Kiyama, Hiroshi

“…Microglia are activated after neuronal injury and in neurodegenerative diseases, and trigger neuroinflammation in the central nervous system (CNS)…”
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Phagocytic astrocytes: Emerging from the shadows of microglia by Konishi, Hiroyuki, Koizumi, Schuichi, Kiyama, Hiroshi

“…Elimination of dead or live cells take place in both a healthy and diseased central nervous system (CNS). Dying or dead cells are quickly cleared by…”
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Mitochondrial behavior during axon regeneration/degeneration in vivo by Kiryu-Seo, Sumiko, Kiyama, Hiroshi

“…•Mitochondrial behavior in an axon reflects axonal condition.•Increased supply of healthy mitochondria facilitates axon regeneration.•In vivo imaging of…”
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TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain by Kobayashi, Masaaki, Konishi, Hiroyuki, Sayo, Akira, Takai, Toshiyuki, Kiyama, Hiroshi

“…Neuropathic pain afflicts millions of people, and the development of an effective treatment for this intractable pain is an urgent issue. Recent evidence has…”
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Dual microglia effects on blood brain barrier permeability induced by systemic inflammation by Haruwaka, Koichiro, Ikegami, Ako, Tachibana, Yoshihisa, Ohno, Nobuhiko, Konishi, Hiroyuki, Hashimoto, Akari, Matsumoto, Mami, Kato, Daisuke, Ono, Riho, Kiyama, Hiroshi, Moorhouse, Andrew J., Nabekura, Junichi, Wake, Hiroaki

“…Microglia survey brain parenchyma, responding to injury and infections. Microglia also respond to systemic disease, but the role of blood–brain barrier (BBB)…”
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Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction by Konishi, Hiroyuki, Okamoto, Takayuki, Hara, Yuichiro, Komine, Okiru, Tamada, Hiromi, Maeda, Mitsuyo, Osako, Fumika, Kobayashi, Masaaki, Nishiyama, Akira, Kataoka, Yosky, Takai, Toshiyuki, Udagawa, Nobuyuki, Jung, Steffen, Ozato, Keiko, Tamura, Tomohiko, Tsuda, Makoto, Yamanaka, Koji, Ogi, Tomoo, Sato, Katsuaki, Kiyama, Hiroshi

“…Microglia are the principal phagocytes that clear cell debris in the central nervous system (CNS). This raises the question, which cells remove cell debris…”
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Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1‐ and SOD1‐linked ALS by Watanabe, Seiji, Ilieva, Hristelina, Tamada, Hiromi, Nomura, Hanae, Komine, Okiru, Endo, Fumito, Jin, Shijie, Mancias, Pedro, Kiyama, Hiroshi, Yamanaka, Koji

“…A homozygous mutation in the gene for sigma 1 receptor (Sig1R) is a cause of inherited juvenile amyotrophic lateral sclerosis (ALS16). Sig1R localizes to the…”
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Morphology, localization, and postnatal development of dural macrophages by Sato, Takehito, Konishi, Hiroyuki, Tamada, Hiromi, Nishiwaki, Kimitoshi, Kiyama, Hiroshi

“…The dura mater contains abundant macrophages whose functions remain largely elusive. Recent studies have demonstrated the origin, as well as the gene…”
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Dual functions of microglia in the formation and refinement of neural circuits during development by Konishi, Hiroyuki, Kiyama, Hiroshi, Ueno, Masaki

“…•Microglia control the production and survival of neuronal cells.•Microglia regulate neuronal migration and axonal growth.•Microglia control synaptogenesis and…”
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A mouse model of microglia-specific ablation in the embryonic central nervous system by Li, Chenmin, Konishi, Hiroyuki, Nishiwaki, Kimitoshi, Sato, Katsuaki, Miyata, Takaki, Kiyama, Hiroshi

“…•A technique for microglia-specific ablation in the embryonic CNS was established.•Siglec-H is specifically expressed by microglia in the embryonic…”
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GPR34 in spinal microglia exacerbates neuropathic pain in mice by Sayo, Akira, Konishi, Hiroyuki, Kobayashi, Masaaki, Kano, Kuniyuki, Kobayashi, Hiroki, Hibi, Hideharu, Aoki, Junken, Kiyama, Hiroshi

“…Neuropathic pain is caused by sensory nerve injury, but effective treatments are currently lacking. Microglia are activated in the spinal dorsal horn after…”
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A DAP12-Dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons by Kobayashi, Masaaki, Konishi, Hiroyuki, Takai, Toshiyuki, Kiyama, Hiroshi

“…Under pathological conditions, activated microglia play paradoxical roles and could have neurotoxic or neuroprotective effects. However, the signal determining…”
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Down-regulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity by Toda, Takuya, Ishida, Kazuto, Kiyama, Hiroshi, Yamashita, Toshihide, Lee, Sachiko

“…Spasticity obstructs motor function recovery post-stroke, and has been reported to occur in spinal cord injury and electrophysiological studies. The purpose of…”
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A Chronic fatigue syndrome model demonstrates mechanical allodynia and muscular hyperalgesia via spinal microglial activation by Yasui, Masaya, Yoshimura, Takashi, Takeuchi, So, Tokizane, Kyohei, Tsuda, Makoto, Inoue, Kazuhide, Kiyama, Hiroshi

“…Patients with chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS) display multiple symptoms, such as chronic widespread pain, fatigue, sleep…”
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Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development by Matsumoto, Sakiko, Kiryu-Seo, Sumiko, Kiyama, Hiroshi

“…Damage-induced neuronal endopeptidase (DINE)/endothelin-converting enzyme-like 1 (ECEL1) is a membrane-bound metalloprotease, which we originally identified as…”
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Correction: Damage-induced neuronal endopeptidase (DINE) enhances axonal regeneration potential of retinal ganglion cells after optic nerve injury by Kaneko, Aoi, Kiryu-Seo, Sumiko, Matsumoto, Sakiko, Kiyama, Hiroshi

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice by Wakatsuki, Koji, Kiryu-Seo, Sumiko, Yasui, Masaya, Yokota, Hiroki, Kida, Haruku, Konishi, Hiroyuki, Kiyama, Hiroshi

“…Fibromyalgia is characterized by chronic pain, fatigue, and other somatic symptoms. We have recently revealed that proprioceptor hyperactivation induces…”
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Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome by Yasui, Masaya, Menjyo, Yuki, Tokizane, Kyohei, Shiozawa, Akiko, Tsuda, Makoto, Inoue, Kazuhide, Kiyama, Hiroshi

“…Patients diagnosed with chronic fatigue syndrome (CFS) or fibromyalgia experience chronic pain. Concomitantly, the rat model of CFS exhibits microglial…”
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Expression of ATP-binding cassette transporter A1 is induced by nerve injury and its deficiency affects neurite tip morphology and elongation in cultured neurons by Shishioh, Nobue, Kiryu-Seo, Sumiko, Abe-Dohmae, Sumiko, Yokoyama, Shinji, Kiyama, Hiroshi

“…Axonal regeneration requires changes in the lipid dynamics of the axon membrane for growth and extension. Here, we examined the expression of genes associated…”
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Brain injury triggers cell‐type‐specific and time‐dependent endoplasmic reticulum stress responses by Fan, Qiyan, Takarada‐Iemata, Mika, Okitani, Nahoko, Tamatani, Takashi, Ishii, Hiroshi, Hattori, Tsuyoshi, Kiryu‐Seo, Sumiko, Kiyama, Hiroshi, Hori, Osamu

“…The unfolded protein response (UPR) is a signal transduction network that responds to endoplasmic reticulum (ER) stress by coordinating protein homeostasis to…”
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