Search Results - "KIVISÄKK, Pia"

Alterations of the human gut microbiome in multiple sclerosis by Jangi, Sushrut, Gandhi, Roopali, Cox, Laura M., Li, Ning, von Glehn, Felipe, Yan, Raymond, Patel, Bonny, Mazzola, Maria Antonietta, Liu, Shirong, Glanz, Bonnie L., Cook, Sandra, Tankou, Stephanie, Stuart, Fiona, Melo, Kirsy, Nejad, Parham, Smith, Kathleen, Topçuolu, Begüm D., Holden, James, Kivisäkk, Pia, Chitnis, Tanuja, De Jager, Philip L., Quintana, Francisco J., Gerber, Georg K., Bry, Lynn, Weiner, Howard L.

“…The gut microbiome plays an important role in immune function and has been implicated in several autoimmune disorders. Here we use 16S rRNA sequencing to…”
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A probiotic modulates the microbiome and immunity in multiple sclerosis by Tankou, Stephanie K., Regev, Keren, Healy, Brian C., Tjon, Emily, Laghi, Luca, Cox, Laura M., Kivisäkk, Pia, Pierre, Isabelle V., Hrishikesh, Lokhande, Gandhi, Roopali, Cook, Sandra, Glanz, Bonnie, Stankiewicz, James, Weiner, Howard L.

“…Objective Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing‐remitting multiple sclerosis (MS)…”
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Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome by Roostaei, Tina, Klein, Hans-Ulrich, Ma, Yiyi, Felsky, Daniel, Kivisäkk, Pia, Connor, Sarah M., Kroshilina, Alexandra, Yung, Christina, Kaskow, Belinda J., Shao, Xiaorong, Rhead, Brooke, Ordovás, José M., Absher, Devin M., Arnett, Donna K., Liu, Jia, Patsopoulos, Nikolaos, Barcellos, Lisa F., Weiner, Howard L., De Jager, Philip L.

“…Identifying the effects of genetic variation on the epigenome in disease-relevant cell types can help advance our understanding of the first molecular…”
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Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis by Kivisäkk, Pia, Imitola, Jaime, Rasmussen, Stine, Elyaman, Wassim, Zhu, Bing, Ransohoff, Richard M., Khoury, Samia J.

“…Objective The onset of neurological signs in experimental autoimmune encephalomyelitis is tightly associated with infiltration and reactivation of T cells in…”
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The clinical and molecular spectrum of ZFYVE26-associated hereditary spastic paraplegia: SPG15 by Saffari, Afshin, Kellner, Melanie, Jordan, Catherine, Rosengarten, Helena, Mo, Alisa, Zhang, Bo, Strelko, Oleksandr, Neuser, Sonja, Davis, Marie Y, Yoshikura, Nobuaki, Futamura, Naonobu, Takeuchi, Tomoya, Nabatame, Shin, Ishiura, Hiroyuki, Tsuji, Shoji, Aldeen, Huda Shujaa, Cali, Elisa, Rocca, Clarissa, Houlden, Henry, Efthymiou, Stephanie, Assmann, Birgit, Yoon, Grace, Trombetta, Bianca A, Kivisäkk, Pia, Eichler, Florian, Nan, Haitian, Takiyama, Yoshihisa, Tessa, Alessandra, Santorelli, Filippo M, Sahin, Mustafa, Blackstone, Craig, Yang, Edward, Schüle, Rebecca, Ebrahimi-Fakhari, Darius

“…Abstract In the field of hereditary spastic paraplegia (HSP), progress in molecular diagnostics needs to be translated into robust phenotyping studies to…”
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Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment by Krumbholz, Markus, Theil, Diethilde, Cepok, Sabine, Hemmer, Bernhard, Kivisäkk, Pia, Ransohoff, Richard M., Hofbauer, Monika, Farina, Cinthia, Derfuss, Tobias, Hartle, Caroline, Newcombe, Jia, Hohlfeld, Reinhard, Meinl, Edgar

“…Understanding the mechanisms of immune cell migration to multiple sclerosis lesions offers significant therapeutic potential. This study focused on the…”
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Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation by Imitola, Jaime, Hollingsworth, Ethan W., Watanabe, Fumihiro, Olah, Marta, Elyaman, Wassim, Starossom, Sarah, Kivisäkk, Pia, Khoury, Samia J.

“…A central issue in regenerative medicine is understanding the mechanisms that regulate the self-renewal of endogenous stem cells in response to injury and…”
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Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment by Kivisäkk, Pia, Carlyle, Becky C, Sweeney, Thadryan, Trombetta, Bianca A, LaCasse, Kathryn, El-Mufti, Leena, Tuncali, Idil, Chibnik, Lori B, Das, Sudeshna, Scherzer, Clemens R, Johnson, Keith A, Dickerson, Bradford C, Gomez-Isla, Teresa, Blacker, Deborah, Oakley, Derek H, Frosch, Matthew P, Hyman, Bradley T, Aghvanyan, Anahit, Bathala, Pradeepthi, Campbell, Christopher, Sigal, George, Stengelin, Martin, Arnold, Steven E

“…The last few years have seen major advances in blood biomarkers for Alzheimer's Disease (AD) with the development of ultrasensitive immunoassays, promising to…”
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Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer’s Disease by Quinn, James P., Ethier, Elizabeth C., Novielli, Angelo, Malone, Aygul, Ramirez, Christopher E., Salloum, Lauren, Trombetta, Bianca A., Kivisäkk, Pia, Bremang, Michael, Selzer, Stefan, Fournier, Marjorie, Das, Sudeshna, Xing, Yaoyi, Arnold, Steven E., Carlyle, Becky C.

“…The granin neuropeptide family is composed of acidic secretory signaling molecules that act throughout the nervous system to help modulate synaptic signaling…”
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Jagged1 and Delta1 Differentially Regulate the Outcome of Experimental Autoimmune Encephalomyelitis by Elyaman, Wassim, Bradshaw, Elizabeth M, Wang, Yue, Oukka, Mohamed, Kivisakk, Pia, Chiba, Shigeru, Yagita, Hideo, Khoury, Samia J

“…Notch signaling plays an important role during T cell development in the thymus and in T cell activation but the role of Notch in autoimmunity is not clear. We…”
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Three or more routes for leukocyte migration into the central nervous system by Ransohoff, Richard M, Kivisäkk, Pia, Kidd, Grahame

“…Leukocyte migration into and through tissues is fundamental to normal physiology, immunopathology and host defence. Leukocyte entry into the central nervous…”
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Biomarkers of neurodegeneration and neural injury as potential predictors for delirium by Fong, Tamara G., Vasunilashorn, Sarinnapha M., Kivisäkk, Pia, Metzger, Eran D., Schmitt, Eva M., Marcantonio, Edward R., Jones, Richard N., Shanes, Hannah T., Arnold, Steven E., Inouye, Sharon K., Ngo, Long H.

“…Objectives Determine if biomarkers of Alzheimer's disease and neural injury may play a role in the prediction of delirium risk. Methods In a cohort of older…”
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Correction to “Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer’s Disease” by Quinn, James P., Ethier, Elizabeth C., Novielli, Angelo, Malone, Aygul, Ramirez, Christopher E., Salloum, Lauren, Trombetta, Bianca A., Kivisäkk, Pia, Bremang, Michael, Selzer, Stefan, Fournier, Marjorie, Das, Sudeshna, Xing, Yaoyi, Arnold, Steven E., Carlyle, Becky C.

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Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial by Babu, Suma, Hightower, Baileigh G., Chan, James, Zürcher, Nicole R., Kivisäkk, Pia, Tseng, Chieh-En J., Sanders, Danica L., Robichaud, Ashley, Banno, Haruhiko, Evora, Armineuza, Ashokkumar, Akshata, Pothier, Lindsay, Paganoni, Sabrina, Chew, Sheena, Dojillo, Joanna, Matsuda, Kazuko, Gudesblatt, Mark, Berry, James D., Cudkowicz, Merit E., Hooker, Jacob M, Atassi, Nazem

“…•No significant reduction in brain glial activation measured by PBR28-PET SUVR.•No significant reduction in serum neurofilament light levels over…”
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Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer's disease by Kivisäkk, Pia, Carlyle, Becky C, Sweeney, Thadryan, Quinn, James P, Ramirez, Christopher E, Trombetta, Bianca A, Mendes, Muriel, Brock, Mary, Rubel, Carrie, Czerkowicz, Julie, Graham, Danielle, Arnold, Steven E

“…There is currently a lack of reliable and easily accessible biomarkers predicting cognitive decline in Alzheimer's disease (AD). Synaptic dysfunction and loss…”
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A Nuclear Magnetic Resonance Spectroscopy Method in Characterization of Blood Metabolomics for Alzheimer's Disease by Weng, JianXiang, Muti, Isabella H, Zhong, Anya B, Kivisäkk, Pia, Hyman, Bradley T, Arnold, Steven E, Cheng, Leo L

“…There is currently a crucial need for improved diagnostic techniques and targeted treatment methods for Alzheimer's disease (AD), a disease which impacts…”
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Modulating CCR2 and CCL2 at the blood–brain barrier: relevance for multiple sclerosis pathogenesis by Mahad, Don, Callahan, Melissa K., Williams, Katherine A., Ubogu, Eroboghene E., Kivisäkk, Pia, Tucky, Barbara, Kidd, Grahame, Kingsbury, Gillian A., Chang, Ansi, Fox, Robert J., Mack, Matthias, Sniderman, M. Bradley, Ravid, Rivka, Staugaitis, Susan M., Stins, Monique F., Ransohoff, Richard M.

“…Chemokines and chemokine receptors play a key role in the transmigration of leucocytes across the blood–brain barrier (BBB). CCR2 is the major receptor for…”
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Fatty acid binding protein-4 is associated with disability in multiple sclerosis patients by Bove, Riley, Healy, Brain C, Musallam, Alexander, Soltany, Pejvak, Diaz-Cruz, Camilo, Sattarnezhad, Neda, Glanz, Bonnie I, Kivisäkk, Pia, Miller, Karen K, Chitnis, Tanuja

“…Background: Increased adiposity is a risk factor for multiple sclerosis (MS) and is associated with increased disability scores. Adipokines may mediate the…”
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ATN blood biomarkers are related to digital cognitive assessment in type 1 diabetes by Fonseca, Luciana Mascarenhas, Beeri, Michal Schnaider, Hawks, Zoë W, Jung, Lanee, Cleveland, Michael, Delgado, Nikki, Bulger, Jane, Grinspoon, Elizabeth, Janess, Kamille, Sliwinski, Martin J, Weinstock, Ruth S, Chhatwal, Jasmeer P, Kivisäkk, Pia, Germine, Laura Thi, Chaytor, Naomi S

“…Associations between amyloid-tau-neurodegeneration (ATN) plasma biomarkers and cognition have not been characterized in adults with type 1 diabetes (T1D)…”
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Plasma biomarkers for prognosis of cognitive decline in patients with mild cognitive impairment by Kivisäkk, Pia, Magdamo, Colin, Trombetta, Bianca A, Noori, Ayush, Kuo, Yi kai E, Chibnik, Lori B, Carlyle, Becky C, Serrano-Pozo, Alberto, Scherzer, Clemens R, Hyman, Bradley T, Das, Sudeshna, Arnold, Steven E

“…Abstract Plasma-based biomarkers present a promising approach in the research and clinical practice of Alzheimer's disease as they are inexpensive, accessible…”
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