Search Results - "KIVISÄKK, P."

Multiple sclerosis is associated with an imbalance between tumour necrosis factor‐alpha (TNF‐α)‐ and IL‐10‐secreting blood cells that is corrected by interferon‐beta (IFN‐β) treatment by Özenci, V., Kouwenhoven, M., Huang, Y.‐M., Kivisäkk, P., Link, H.

“…The up‐regulated B cell responses detectable in cerebrospinal fluid (CSF) and the augmented myelin antigen‐specific T cell responses observed in the CSF as…”
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Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells by KIVISÄKK, P, HEALY, B. C, VIGLIETTA, V, QUINTANA, F. J, HOOTSTEIN, M. A, WEINER, H. L, KHOURY, S. J

“…Natalizumab is an antibody directed against integrin alpha4 that reduces disease activity in patients with multiple sclerosis (MS) by blocking migration of T…”
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Neutralizing and binding anti-interferon-β (IFN-β) antibodies. A comparison between IFN-β-1a and IFN-β-1b treatment in multiple sclerosis by Kivisäkk, P., Alm, G. V., Fredrikson, S., Link, H.

“…Interferon‐β (IFN‐β) is currently the most commonly used treatment of relapsing–remitting multiple sclerosis (MS). At the time of this study, two preparations…”
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Three or more routes for leukocyte migration into the central nervous system by Ransohoff, Richard M, Kivisäkk, Pia, Kidd, Grahame

“…Leukocyte migration into and through tissues is fundamental to normal physiology, immunopathology and host defence. Leukocyte entry into the central nervous…”
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Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid by TELESHOVA, Natalia, PASHENKOV, Mikhail, HUANG, Yu-Min, SÖDERSTRÖM, Mats, KIVISÄKK, Pia, KOSTULAS, Vasilios, HAGLUND, Mats, LINK, Hans

“…A role for chemokines as mediators of Th1 cell recruitment to the central nervous system (CNS) is probable in MS. Therefore we studied expression of…”
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IL‐15 mRNA expression is up‐regulated in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis (MS) by KIVISÄKK, P, MATUSEVICIUS, D, HE, B, SÖDERSTRÖM, M, FREDRIKSON, S, LINK, H

“…IL‐15, produced by monocytes and epithelial cells, is a novel cytokine with actions similar to IL‐2. IL‐15 induces T cell proliferation, B cell maturation and…”
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Elevated CD40 Ligand Expressing Blood T‐Cell Levels in Multiple Sclerosis Are Reversed by Interferon‐Beta Treatment by Teleshova, N, Bao, W, Kivisäkk, P, Ozenci, V, Mustafa, M, Link, H

“…Myelin protein reactive CD4+ T cells are considered to be involved in the proposed immunopathogenesis of multiple sclerosis (MS). One particularly important…”
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Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis by Matusevicius, D, Kivisäkk, P, He, B, Kostulas, N, Özenci, V, Fredrikson, S, Link, H

“…Myelin-directed autoimmunity is considered to play a key role in the pathogenesis of multiple sclerosis (MS). Increased production of both pro- and…”
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Neuroprotection of low dose carbon monoxide in Parkinson’s disease models commensurate with the reduced risk of Parkinson’s among smokers by Rose, K. N., Zorlu, M., Fassini, A., Lee, H., Cai, W., Xue, X., Lin, S., Kivisakk, P., Schwarzschild, M. A., Chen, X., Gomperts, S. N.

“…Paradoxically, cigarette smoking is associated with a reduced risk of Parkinson’s Disease (PD). This led us to hypothesize that carbon monoxide (CO) levels,…”
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Levels of Interleukin‐15‐Expressing Blood Mononuclear Cells Are Elevated in Multiple Sclerosis by Pashenkov, M, Mustafa, M, Kivisäkk, P, Link, H

“…Interleukin‐15 (IL‐15) is a novel IL‐2‐like cytokine expressed by cells of the monocyte/macrophage and epithelial lineages. Cytokines might be involved in the…”
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High levels of IL-10 secreting cells are present in blood in cerebrovascular diseases by Pelidou, Sigliti-Henrietta, Kostulas, Nikolaos, Matusevicius, Darius, Kivisäkk, Pia, Kostulas, Vasilios, Link, Hans

“…Ischemic stroke is associated with altered systemic immune responses both early after the onset and in the recovery phase. Interleukin (IL)‐10, a Th2 related…”
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Metalloproteinases and their Tissue Inhibitors in Multiple Sclerosis by Özenci, Volkan, Rinaldi, Luciano, Teleshova, Natalia, Matusevicius, Darius, Kivisäkk, Pia, Kouwenhoven, Mathilde, Link, Hans

“…Matrix metalloproteinases (MMPs) comprise a family of proteolytic enzymes. MMPs are capable of disrupting the blood-brain barrier (BBB), mediating the…”
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Multiple Sclerosis: Levels of Interleukin‐10‐Secreting Blood Mononuclear Cells are Low in Untreated Patients but Augmented During Interferon‐β‐1b Treatment by Özenci, Kouwenhoven, Huang, Xiao, Kivisäkk, Fredrikson, Link

“…The cytokine interleukin (IL)‐10 has immune response down‐regulatory properties, which include suppression of the synthesis of pro‐inflammatory cytokines such…”
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Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis by Huang, D R, Wang, J, Kivisakk, P, Rollins, B J, Ransohoff, R M

“…Monocyte chemoattractant protein (MCP)-1 plays a critical role in innate immunity by directing the migration of monocytes into inflammatory sites. Recent data…”
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Optic neuritis and cytokines : No relation to MRI abnormalities and oligoclonal bands by KIVISÄKK, P, TIAN, W, MATUSEVICIUS, D, LINK, H, SÖDERSTRÖM, M

“…Acute unilateral monosymptomatic optic neuritis (ON) is a common first manifestation of MS if associated with multiple MS-like lesions on brain MRI and…”
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Multiple sclerosis: levels of interleukin-10-secreting blood mononuclear cells are low in untreated patients but augmented during interferon-beta-1b treatment by Ozenci, V, Kouwenhoven, M, Huang, Y M, Xiao, B, Kivisäkk, P, Fredrikson, S, Link, H

“…The cytokine interleukin (IL)-10 has immune response down-regulatory properties, which include suppression of the synthesis of pro-inflammatory cytokines such…”
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Interleukin‐12 and Perforin mRNA Expression is Augmented in Blood Mononuclear Cells in Multiple Sclerosis by Matusevicius, D, Kivisäkk, P, Navikas, V, Söderström, M, Fredrikson, S, Link, H

“…Cytokines are suggested to orchestrate an abnormal immune response in multiple sclerosis (MS). The regulatory cytokine interleukin (IL)‐12 induces T‐helper…”
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Cytokine autoantibodies in multiple sclerosis, aseptic meningitis and stroke by Elkarim, R A, Mustafa, M, Kivisäkk, P, Link, H, Bakhiet, M

“…Background We have recently described the induction of anti‐cytokine autoantibodies during bacterial infections and autoimmune diseases as a mechanism for…”
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T‐cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking by KIVISÄKK, P., TREBST, C., LIU, Z., TUCKY, B. H., SØRENSEN, T. L., RUDICK, R. A., MACK, M., RANSOHOFF, R. M.

“…SUMMARY It is believed that chemokines and their receptors are involved in trafficking of T‐cells to the central nervous system (CNS). The aim of the current…”
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Altered expression of costimulatory molecules in myasthenia gravis by Teleshova, Natalia, Matusevicius, Darius, Kivisäkk, Pia, Mustafa, Maha, Pirskanen, Ritva, Link, Hans

“…To characterize the involvement of costimulatory pathways in the pathogenesis of myasthenia gravis (MG), a multiparameter flow cytometry assay was adopted to…”
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