Search Results - "KITTLER, Josef"

Mitochondria at the neuronal presynapse in health and disease by Devine, Michael J., Kittler, Josef T.

“…Key Points Synaptic communication within the nervous system is a highly energy-demanding process that is tightly regulated by Ca 2+ signalling Mitochondria are…”
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Miro proteins coordinate microtubule‐ and actin‐dependent mitochondrial transport and distribution by López‐Doménech, Guillermo, Covill‐Cooke, Christian, Ivankovic, Davor, Halff, Els F, Sheehan, David F, Norkett, Rosalind, Birsa, Nicol, Kittler, Josef T

“…In the current model of mitochondrial trafficking, Miro1 and Miro2 Rho‐GTPases regulate mitochondrial transport along microtubules by linking mitochondria to…”
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Control of mitochondrial transport and localization in neurons by MacAskill, Andrew F, Kittler, Josef T

“…Mitochondria play an essential role in ATP generation, calcium buffering and apoptotic signalling. In neurons, the transport of mitochondria to specific…”
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Mitochondrial regulation of local supply of energy in neurons by López-Doménech, Guillermo, Kittler, Josef T.

“…Brain computation is metabolically expensive and requires the supply of significant amounts of energy. Mitochondria are highly specialized organelles whose…”
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Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites by López-Doménech, Guillermo, Higgs, Nathalie F., Vaccaro, Victoria, Roš, Hana, Arancibia-Cárcamo, I. Lorena, MacAskill, Andrew F., Kittler, Josef T.

“…Correct mitochondrial distribution is critical for satisfying local energy demands and calcium buffering requirements and supporting key cellular processes…”
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Miro clusters regulate ER-mitochondria contact sites and link cristae organization to the mitochondrial transport machinery by Modi, Souvik, López-Doménech, Guillermo, Halff, Elise F., Covill-Cooke, Christian, Ivankovic, Davor, Melandri, Daniela, Arancibia-Cárcamo, I. Lorena, Burden, Jemima J., Lowe, Alan R., Kittler, Josef T.

“…Mitochondrial Rho (Miro) GTPases localize to the outer mitochondrial membrane and are essential machinery for the regulated trafficking of mitochondria to…”
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Miro1‐dependent mitochondrial positioning drives the rescaling of presynaptic Ca2+ signals during homeostatic plasticity by Vaccaro, Victoria, Devine, Michael J, Higgs, Nathalie F, Kittler, Josef T

“…Mitochondrial trafficking is influenced by neuronal activity, but it remains unclear how mitochondrial positioning influences neuronal transmission and…”
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Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins by Birsa, Nicol, Norkett, Rosalind, Higgs, Nathalie, Lopez-Domenech, Guillermo, Kittler, Josef T

“…Correct mitochondrial dynamics are essential to neuronal function. These dynamics include mitochondrial trafficking and quality-control systems that maintain a…”
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Exploiting Deep Learning in Limited-Fronthaul Cell-Free Massive MIMO Uplink by Bashar, Manijeh, Akbari, Ali, Cumanan, Kanapathippillai, Ngo, Hien Quoc, Burr, Alister G., Xiao, Pei, Debbah, Merouane, Kittler, Josef

“…A cell-free massive multiple-input multiple-output (MIMO) uplink is considered, where quantize-and-forward (QF) refers to the case where both the channel…”
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Nanoscale tweezers for single-cell biopsies by Nadappuram, Binoy Paulose, Cadinu, Paolo, Barik, Avijit, Ainscough, Alexander J., Devine, Michael J., Kang, Minkyung, Gonzalez-Garcia, Jorge, Kittler, Josef T., Willison, Keith R., Vilar, Ramon, Actis, Paolo, Wojciak-Stothard, Beata, Oh, Sang-Hyun, Ivanov, Aleksandar P., Edel, Joshua B.

“…Much of the functionality of multicellular systems arises from the spatial organization and dynamic behaviours within and between cells. Current single-cell…”
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Regulation of peroxisomal trafficking and distribution by Covill-Cooke, Christian, Toncheva, Viktoriya S., Kittler, Josef T.

“…Peroxisomes are organelles that perform a wide range of essential metabolic processes. To ensure that peroxisomes are optimally positioned in the cell, they…”
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The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C by Twelvetrees, Alison E, Lesept, Flavie, Holzbaur, Erika L F, Kittler, Josef T

“…Binding of motor proteins to cellular cargoes is regulated by adaptor proteins. HAP1 and GRIP1 are kinesin-1 adaptors that have been implicated individually in…”
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Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition by Davenport, Elizabeth C., Szulc, Blanka R., Drew, James, Taylor, James, Morgan, Toby, Higgs, Nathalie F., López-Doménech, Guillermo, Kittler, Josef T.

“…Altered excitatory/inhibitory (E/I) balance is implicated in neuropsychiatric and neurodevelopmental disorders, but the underlying genetic etiology remains…”
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Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome by Ivankovic, Davor, Drew, James, Lesept, Flavie, White, Ian J., López Doménech, Guillermo, Tooze, Sharon A., Kittler, Josef T.

“…Adaptor protein (AP) complexes mediate key sorting decisions in the cell through selective incorporation of transmembrane proteins into vesicles. Little is…”
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Miro sculpts mitochondrial dynamics in neuronal health and disease by Devine, Michael J, Birsa, Nicol, Kittler, Josef T

“…Abstract Neurons are highly polarised cells with an elaborate and diverse cytoarchitecture. But this complex architecture presents a major problem: how to…”
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An Anomaly Detection Approach to Face Spoofing Detection: A New Formulation and Evaluation Protocol by Arashloo, Shervin Rahimzadeh, Kittler, Josef, Christmas, William

“…Face spoofing detection is commonly formulated as a two-class recognition problem where relevant features of both positive (real access) and negative samples…”
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Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling by Stephen, Terri-Leigh, Higgs, Nathalie F, Sheehan, David F, Al Awabdh, Sana, López-Doménech, Guillermo, Arancibia-Carcamo, I Lorena, Kittler, Josef T

“…It is fast emerging that maintaining mitochondrial function is important for regulating astrocyte function, although the specific mechanisms that govern…”
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SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction by Hirunpattarasilp, Chanawee, James, Greg, Kwanthongdee, Jaturon, Freitas, Felipe, Huo, Jiandong, Sethi, Huma, Kittler, Josef T, Owens, Raymond J, McCoy, Laura E, Attwell, David

“…The SARS-CoV-2 receptor, ACE2, is found on pericytes, contractile cells enwrapping capillaries that regulate brain, heart and kidney blood flow. ACE2 converts…”
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Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase by Birsa, Nicol, Norkett, Rosalind, Wauer, Tobias, Mevissen, Tycho E.T., Wu, Hsiu-Chuan, Foltynie, Thomas, Bhatia, Kailash, Hirst, Warren D., Komander, David, Plun-Favreau, Helene, Kittler, Josef T.

“…Mitochondrial transport plays an important role in matching mitochondrial distribution to localized energy production and calcium buffering requirements. Here,…”
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Peroxisomal fission is modulated by the mitochondrial Rho‐GTPases, Miro1 and Miro2 by Covill‐Cooke, Christian, Toncheva, Viktoriya S, Drew, James, Birsa, Nicol, López‐Doménech, Guillermo, Kittler, Josef T

“…Peroxisomes are essential for a number of cellular functions, including reactive oxygen species metabolism, fatty acid β‐oxidation and lipid synthesis. To…”
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