Search Results - "KITSON, T. M"

Systematic review: current concepts and challenges for the direct‐acting antiviral era in hepatitis C cirrhosis by Majumdar, A., Kitson, M. T., Roberts, S. K.

“…Summary Background The burden of HCV cirrhosis is high and projected to increase significantly over the next decade. While interferon therapy is problematic in…”
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Probing the active site of cytoplasmic aldehyde dehydrogenase with a chromophoric reporter group by KITSON, T. M, KITSON, K. E

“…3,4-Dihydro-3-methyl-6-nitro-2H-1,3-benzoxazin-2-one ('DMNB') reacts with cytoplasmic aldehyde dehydrogenase in a similar way to that previously observed with…”
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Identification of a catalytically essential nucleophilic residue in sheep liver cytoplasmic aldehyde dehydrogenase by KITSON, T. M, HILL, J. P, MIDWINTER, G. G

“…Sheep liver cytoplasmic aldehyde dehydrogenase was labelled by reaction with the substrate p-nitrophenyl di[14C]methylcarbamate. After tryptic digestion and…”
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Effect of some thiocarbamate compounds on aldehyde dehydrogenase and implications for the disulfiram ethanol reaction by Kitson, T M

“…The effects of S-methyl diethyldithiocarbamate, S-methyl diethylmonothiocarbamate and bis(diethylcarbamoyl) disulphide on sheep liver cytoplasmic aldehyde…”
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Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases by Moore, Stanley A, Baker, Heather M, Blythe, Treena J, Kitson, Kathryn E, Kitson, Trevor M, Baker, Edward N

“…Background: Enzymes of the aldehyde dehydrogenase family are required for the clearance of potentially toxic aldehydes, and are essential for the production of…”
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Covalent modification of sheep liver cytosolic aldehyde dehydrogenase by the oxidative addition of coloured phenoxazine, phenothiazine and phenazine derivatives by Kitson, T M, Kitson, K E, King, G J

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Kinetics of p-nitrophenyl pivalate hydrolysis catalysed by cytoplasmic aldehyde dehydrogenase by Kitson, T M

“…The effects of modifiers (NAD+, NADH, propionaldehyde, chloral hydrate, diethylstilboestrol and p-nitrobenzaldehyde) on the hydrolysis of p-nitrophenyl (PNP)…”
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Felinine stability in the presence of selected urine compounds by Rutherfurd, S M, Kitson, T M, Woolhouse, A D, McGrath, M C, Hendriks, W H

“…The stability of felinine, an amino acid present in feline urine, was investigated. Synthetic felinine was unstable in the urine of a selection of mammals…”
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Mechanism of inactivation of sheep liver cytoplasmic aldehyde dehydrogenase by disulfiram by Kitson, T M

“…Stoicheiometric amounts of [14C]disulfiram react rapidly with sheep liver cytoplasmic aldehyde dehydrogenase to give loss of catalytic activity and…”
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A structural explanation for the retinal specificity of class 1 ALDH enzymes by Moore, S A, Baker, H M, Blythe, T J, Kitson, K E, Kitson, T M, Baker, E N

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The effect of disulfiram on the aldehyde dehydrogenases of sheep liver by Kitson, T M

“…1. The effect of disulfiram on the activity of the cytoplasmic and mitochondrial aldehyde dehydrogenases of sheep liver was studied. 2. Disulfiram causes an…”
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Reaction between sheep liver mitochondrial aldehyde dehydrogenase and a chromogenic 'reporter group' reagent by King, G J, Norris, G E, Kitson, K E, Kitson, T M

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Effect of disulfiram on the pre-steady-state burst in the reactions of sheep liver cytoplasmic aldehyde dehydrogenase by Kitson, T M

“…Stopped-flow spectrophotometric experiments show that modification by disulfiram not only lowers the steady-state rates but also decreases the size of bursts…”
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Use of a chromophoric reporter group to probe the active site of cytosolic aldehyde dehydrogenase by Kitson, T M, Kitson, K E

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Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase by Kitson, T M

“…1. Pre-modification of cytoplasmic aldehyde dehydrogenase by disulfiram results in the same extent of inactivation when the enzyme is subsequently assayed as a…”
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Studies on the interaction between disulfiram and sheep liver cytoplasmic aldehyde dehydrogenase by Kitson, T M

“…The effect of disulfiram, [1-14C]disulfiram and some other thiol reagents on the activity of cytoplasmic aldehyde dehydrogenase from sheep liver was studied…”
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High concentrations of aldehydes slow the reaction of cytoplasmic aldehyde dehydrogenase with thiol-group modifiers by Kitson, T M

“…High concentrations of aldehydes slow the inactivation of cytoplasmic aldehyde dehydrogenase by disulfiram and also slow the reaction of the enzyme with…”
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Studies of the esterase activity of cytosolic aldehyde dehydrogenase using sterically hindered and cyclic substrates by Kitson, K E, Blythe, T J, Kitson, T M

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The inactivation of aldehyde dehydrogenase by disulfiram in the presence of glutathione by Kitson, T M

“…It is shown that in vitro glutathione provides little protection of cytoplasmic aldehyde dehydrogenase against the inactivatory action of disulfiram. This…”
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Human class 1 aldehyde dehydrogenase. Expression and site-directed mutagenesis by Jones, K M, Kitson, T M, Kitson, K E, Hardman, M J, Tweedie, J W

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