Search Results - "KITCHEN, Valerie"

Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist by Jenkins, Julian M., Williams, Daphne, Deng, Yanli, Uhl, Joanne, Kitchen, Valerie, Collins, David, Erickson-Miller, Connie L.

“…Eltrombopag (SB-497 115) is a first-in-class, oral, small-molecule, nonpeptide agonist of the thrombopoietin receptor (TpoR), being developed as a treatment…”
Get full text

Eltrombopag, an oral thrombopoietin receptor agonist, has no impact on the pharmacokinetic profile of probe drugs for cytochrome P450 isoenzymes CYP3A4, CYP1A2, CYP2C9 and CYP2C19 in healthy men: a cocktail analysis by Jenkins, Julian, Williams, Daphne, Deng, Yanli, Collins, David A, Kitchen, Valerie S

“…Purpose It is likely that the thrombopoietin receptor agonist eltrombopag will be administered concomitantly with other medications in the treatment of…”
Get full text

Dextrin Sulfate as a Vaginal Microbicide: Randomized, Double-Blind, Placebo-Controlled Trial Including Healthy Female Volunteers and Their Male Partners by Low-Beer, Naomi, Gabe, Rhian, McCormack, Sheena, Kitchen, Valerie S, Lacey, Charles J, Nunn, Andrew J

“…This randomized, placebo-controlled trial assessed the safety and acceptability of vaginally administered 0.125% dextrin sulfate (DS) gel in sexually active…”
Get full text

Effect on Normal Vaginal Flora of Three Intravaginal Microbicidal Agents Potentially Active against Human Immunodeficiency Virus Type 1 by Rosenstein, Isobel J., Stafford, Michael K., Kitchen, Valerie S., Ward, Helen, Weber, Jonathan N., Taylor-Robinson, David

“…The effect on normal vaginal flora of three intravaginal microbicides potentially active against human immunodeficiency virus type 1 was examined. Volunteers…”
Get full text

'Chemical condoms' for the prevention of HIV infection: evaluation of novel agents against SHIV89.6PD In vitro and In vivo by WEBER, Jonathan, NUNN, Andrew, O'CONNOR, Tim, JEFFRIES, Don, KITCHEN, Valerie, MCCORMACK, Sheena, STOTT, Jim, ALMOND, Neil, STONE, Alan, DARBYSHIRE, Janet

Get full text

Safety and activity of saquinavir in HIV infection by Kitchen, V S, Skinner, C, Ariyoshi, K, Lane, E A, Duncan, I B, Burckhardt, J, Burger, H U, Bragman, K, Pinching, A J, Weber, J N

“…We evaluated saquinavir, an orally active, selective inhibitor of HIV proteinase, in a randomised, double-blind, dose-ranging study in 49 zidovudine-naive…”
Get more information

An Oral, Non-Petide, Small Molecule Thrombopoietin Receptor Agonist Increases Platelet Counts in Healthy Subjects by Jenkins, Julian, Nicholl, Richard, Williams, Daphne, Baidoo, Charlotte, Phillips, Jennifer, Deng, Yanli, Kitchen, Valerie, Erickson-Miller, Connie

“…SB497115, is an orally bioavailable, small molecule thrombopoietin receptor agonist that induces differentiation and proliferation of megakaryocytes. In a…”
Get full text

Evaluation of Safety and Efficacy of 3TC (Lamivudine) in Patients with Asymptomatic or Mildly Symptomatic Human Immunodeficiency Virus Infection: A Phase I/II Study by van Leeuwen, Remko, Katlama, Christine, Kitchen, Valerie, Boucher, Charles A. B., Tubiana, Roland, McBride, Michael, Ingrand, Didier, Weber, Jonathan, Hill, Andrew, McDade, Hugh, Danner, Sven A.

“…In a phase 1/11 study, 7 levelsof3TC therapy (from 0.5 to 20.0 mg/kg/day) were studied in 104 asymptomatic and mildly symptomatic human immunodeficiency…”
Get full text

Chemical condoms’ for the prevention of HIV infection: evaluation of novel agents against SHIV89.6PDin vitro and in vivo by Weber, Jonathan, Nunn, Andrew, O'Connor, Tim, Jeffries, Don, Kitchen, Valerie, McCormack, Sheena, Stott, Jim, Almond, Neil, Stone, Alan, Darbyshire, Janet

Get full text

Nonoxynol-9 in lubricated condoms by Ward, Helen, De La Court, Annette, Kitchen, Valerie

“…Debate continues on the efficacy and safety of intravaginal nonoxynol-9 for the prevention of horizontal transmission of HIV and other STDs. The tolerability…”
Get full text

Nonoxynol-9 in Lubricated Condoms: Results of a Study in Female Prostitutes by WARD, HELEN, DE LA COURT, ANNETTE, KITCHEN, VALERIE

“…Background and Objectives: Debate continues on the efficacy and safety of intravaginal nonoxynol-9 for the prevention of horizontal transmission of human…”
Get full text

Antiretroviral Drug Trials by Breckenridge, Alasdair, Kitchen, Valerie, Darbyshire, Janet H., Koen K. A. Van Rompay, Marthas, Marta L., Joep M. A. Lange

Get full text

Emerging proteinase inhibitors by Kitchen, V, Stewart, F, Bragman, K, Weber, J

Get more information

Safety study of nonoxynol-9 as a vaginal microbicide : Evidence of adverse effects by STAFFORD, M. K, WARD, H, FLANAGAN, A, ROSENSTEIN, I. J, TAYLOR-ROBINSON, D, SMITH, J. R, WEBER, J, KITCHEN, V. S

“…Nonoxynol-9 (N-9) is virucidal in vitro, and is therefore a candidate microbicide for preventing sexual transmission of HIV. However, the activity of N-9 is…”
Get full text

Changing patterns of HIV-1 transmission in southern Brazil 1985-1991 by Santos, B R, Beck, E J, Peixoto, M F, Kitchen, V, Weber, J

“…In order to describe the changing patterns of risk factors for HIV-1 transmission of patients using hospital services at an AIDS referral centre in Porto…”
Get more information

Long Term Management After Splenectomy by Flegg, Peter J., Reilly, Sheena, Prentice, A. G., Copplestone, J. A., Hamon, M. D., Sarangi, Joyshri, Makris, M., Greaves, M., Winfield, D. A., Preston, F. E., Lilleyman, J. S., Finch, R. G., Read, R., Baddeley, Peter, Boyer, Penny, Mayon-White, Dick, Cooke, R. P. D., Gover, P. A., Grace, R. J., Muller, A. F., Toghill, P. J., Fisher, Martin, Peters, Barry, McBride, Michael, Kitchen, Valerie, Taylor, P. R. A., Howard, M. R., Graham, Rory C. A., Davies, Kevin A., Beynon, Huw L. C., Walport, Mark J.

Get full text

A placebo-controlled, double-blind prospective study in healthy female volunteers of dextrin sulphate gel. A novel potential intravaginal virucide by STAFFORD, M. K, CAIN, D, ROSENSTEIN, I, FONTAINE, E. A, MCCLURE, M, FLANAGAN, A. M, SMITH, J. R, TAYLOR-ROBINSON, D, WEBER, J, KITCHEN, V. S

“…A double-blind, placebo-controlled study was designed to evaluate the safety and tolerability of intravaginal dextrin sulphate (D2S) gel to assess its…”
Get full text