Search Results - "KITAMURA, TADAHIRO"

Glucagon: Physiological and Pharmacological Functions and Pathophysiological Significance in Type 2 Diabetes by Kitamura, Tadahiro

“…Glucagon has many functions, including the promotion of hepatic glucose production, fatty acid oxidation, thermogenesis, energy consumption, lipolysis, and…”
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Advances in the clinical measurement of glucagon: from diagnosis to therapy by Kitamura, Tadahiro, Kobayashi, Masaki

“…Glucagon has many functions: it promotes glucose production, fatty acid oxidation, thermogenesis, energy consumption, lipolysis, and myocardial contraction,…”
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Basal glucagon hypersecretion and response to oral glucose load in prediabetes and mild type 2 diabetes by Ichikawa, Raishi, Takano, Koji, Fujimoto, Kazumi, Motomiya, Tetsuya, Kobayashi, Masaki, Kitamura, Tadahiro, Shichiri, Masayoshi

“…Dysregulation of glucagon secretion plays an important role in the pathogenesis of type 2 diabetes (T2DM). However it hasn’t been elucidated involvement of…”
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Anagliptin suppresses diet-induced obesity through enhancing leptin sensitivity and ameliorating hyperphagia in high-fat high-sucrose diet fed mice by Kohno, Daisuke, Furusawa, Kenichi, Kitamura, Tadahiro

“…Obesity is a major risk factors for type 2 diabetes, and weight loss is beneficial to diabetic patients who are obese or overweight. Dipeptidyl peptidase-4…”
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Generation of functional insulin-producing cells in the gut by Foxo1 ablation by Talchai, Chutima, Xuan, Shouhong, Kitamura, Tadahiro, DePinho, Ronald A, Accili, Domenico

“…Domenico Accili and colleagues report that somatic ablation of Foxo1 in enteroendocrine progenitor cells leads to gut insulin-positive cells that have…”
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Cell Autonomous Dysfunction and Insulin Resistance in Pancreatic α Cells by Honzawa, Norikiyo, Fujimoto, Kei, Kitamura, Tadahiro

“…To date, type 2 diabetes is considered to be a "bi-hormonal disorder" rather than an "insulin-centric disorder," suggesting that glucagon is as important as…”
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Roles of FoxO1 and Sirt1 in the central regulation of food intake by Sasaki, Tsutomu, Kitamura, Tadahiro

“…The hypothalamus is the center of controlling food intake and energy expenditure by integrating information on energy status, i.e. adiposity and nutrient…”
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Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load by Kuramoto, Naoki, Nomura, Kazuhiro, Kohno, Daisuke, Kitamura, Tadahiro, Karsenty, Gerard, Hosooka, Tetsuya, Ogawa, Wataru

“…Phosphatidylinositol 3-kinase (PI3K) plays an important role in protein metabolism and cell growth. We here show that mice (M-PDK1KO mice) with skeletal…”
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Total Pancreatectomy in a Patient Treated with a Sensor-augmented Pump Showing No Evidence of Hyperglycemia or Ketoacidosis without Any Insulin Administration by Ito, Hiroki, Yamada, Eijiro, Kobayashi, Masaki, Horiguchi, Kazuhiko, Okada, Shuichi, Kitamura, Tadahiro, Yamada, Masanobu

“…Total pancreatectomy results in complete loss of insulin and glucagon. Sensor-augmented pumps (SAPs) allow fine-tuning of the basal insulin rate, which helps…”
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Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice by Matsui, Sho, Sasaki, Tsutomu, Kohno, Daisuke, Yaku, Keisuke, Inutsuka, Ayumu, Yokota-Hashimoto, Hiromi, Kikuchi, Osamu, Suga, Takayoshi, Kobayashi, Masaki, Yamanaka, Akihiro, Harada, Akihiro, Nakagawa, Takashi, Onaka, Tatsushi, Kitamura, Tadahiro

“…Diet affects health through ingested calories and macronutrients, and macronutrient balance affects health span. The mechanisms regulating macronutrient-based…”
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Plasma glucagon levels measured by sandwich ELISA are correlated with impaired glucose tolerance in type 2 diabetes by Kobayashi, Masaki, Satoh, Hiroaki, Matsuo, Toshihiro, Kusunoki, Yoshiki, Tokushima, Masahiko, Watada, Hirotaka, Namba, Mitsuyoshi, Kitamura, Tadahiro

“…Glucagon dysfunction as well as insulin dysfunction is associated with the pathogenesis of type 2 diabetes (T2DM). However, it is still unclear whether the…”
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A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon‐derived peptide levels by Kobayashi, Masaki, Maruyama, Nobuhiro, Yamamoto, Yukako, Togawa, Takeshi, Ida, Takanori, Yoshida, Morikatsu, Miyazato, Mikiya, Kitada, Masahisa, Hayashi, Yoshitaka, Kashiwagi, Atsunori, Kitamura, Tadahiro

“…Aims/Introduction Glucagon, a peptide hormone produced from proglucagon, is involved in the pathophysiology of diabetes. Plasma glucagon levels are currently…”
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Effects of a new 75 g glucose- and high fat-containing cookie meal test on postprandial glucose and triglyceride excursions in morbidly obese patients by Yamamoto, Yukako, Ozamoto, Yuki, Kobayashi, Masaki, Tezuka, Yuji, Azuma, Choka, Sekine, Osamu, Ito-Kobayashi, Jun, Washiyama, Miki, Oe, Yasumitsu, Iwanishi, Masanori, Togawa, Takeshi, Hagiwara, Akeo, Kitamura, Tadahiro, Shimatsu, Akira, Kashiwagi, Atsunori

“…A new meal tolerance test (MTT) using a 75 g glucose- and high fat-containing meal was applied to classify glucose intolerance in morbidly obese patients…”
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A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells by Masubuchi, Yosuke, Nakagawa, Yuko, Ma, Jinhui, Sasaki, Tsutomu, Kitamura, Tadahiro, Yamamoto, Yoritsuna, Kurose, Hitoshi, Kojima, Itaru, Shibata, Hiroshi

“…Sweet taste receptor is expressed not only in taste buds but also in nongustatory organs such as enteroendocrine cells and pancreatic beta-cells, and may play…”
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Hepatic Gluconeogenic Response to Single and Long-Term SGLT2 Inhibition in Lean/Obese Male Hepatic G6pc-Reporter Mice by Inaba, Yuka, Hashiuchi, Emi, Watanabe, Hitoshi, Kimura, Kumi, Sato, Makoto, Kobayashi, Masaki, Matsumoto, Michihiro, Kitamura, Tadahiro, Kasuga, Masato, Inoue, Hiroshi

“…Sodium-glucose cotransporter 2 inhibitor (SGLT2i) consistently reduces blood glucose levels in type 2 diabetes mellitus but increases hepatic gluconeogenic…”
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Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness by Kohno, Daisuke, Koike, Miho, Ninomiya, Yuzo, Kojima, Itaru, Kitamura, Tadahiro, Yada, Toshihiko

“…The hypothalamic feeding center plays an important role in energy homeostasis. In the feeding center, whole-body energy signals including hormones and…”
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ChREBP-Knockout Mice Show Sucrose Intolerance and Fructose Malabsorption by Kato, Takehiro, Iizuka, Katsumi, Takao, Ken, Horikawa, Yukio, Kitamura, Tadahiro, Takeda, Jun

“…We have previously reported that 60% sucrose diet-fed knockout mice (KO) showed body weight loss resulting in lethality. We aimed to elucidate whether sucrose…”
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Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression by Fukunaka, Ayako, Fukada, Toshiyuki, Bhin, Jinhyuk, Suzuki, Luka, Tsuzuki, Takamasa, Takamine, Yuri, Bin, Bum-Ho, Yoshihara, Toshinori, Ichinoseki-Sekine, Noriko, Naito, Hisashi, Miyatsuka, Takeshi, Takamiya, Shinzaburo, Sasaki, Tsutomu, Inagaki, Takeshi, Kitamura, Tadahiro, Kajimura, Shingo, Watada, Hirotaka, Fujitani, Yoshio

“…Given the relevance of beige adipocytes in adult humans, a better understanding of the molecular circuits involved in beige adipocyte biogenesis has provided…”
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Robust increase in glucagon secretion after oral protein intake, but not after glucose or lipid intake in Japanese people without diabetes by Ichikawa, Raishi, Takano, Koji, Fujimoto, Kazumi, Kobayashi, Masaki, Kitamura, Tadahiro, Shichiri, Masayoshi, Miyatsuka, Takeshi

“…Few studies in Asian populations have analyzed how glucagon secretion is affected by ingested glucose, proteins or lipids, individually. To investigate the…”
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TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass by Takamoto, Iseki, Kubota, Naoto, Nakaya, Keizo, Kumagai, Katsuyoshi, Hashimoto, Shinji, Kubota, Tetsuya, Inoue, Mariko, Kajiwara, Eiji, Katsuyama, Hisayuki, Obata, Atsushi, Sakurai, Yoshitaka, Iwamoto, Masahiko, Kitamura, Tadahiro, Ueki, Kohjiro, Kadowaki, Takashi

“…Aims/hypothesis Common genetic variations of the transcription factor 7-like 2 gene (encoded by TCF7L2 ), one of the T cell factor/lymphoid enhancer-binding…”
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