ELEVATED CARBOHYDRATE-DEFICIENT TRANSFERRIN PREDICTS PROLONGED INTENSIVE CARE UNIT STAY IN TRAUMATIZED MEN

Carbohydrate-deficient transferrin (CDT) is reported to have a higher specificity in alcoholism than conventional markers. As the morbidity and mortality rates amongst chronic alcoholics are raised following trauma, the objective was to investigate if CDT could be used to predict prolonged intensive...

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Published in:	Alcohol and alcoholism (Oxford) Vol. 33; no. 6; pp. 661 - 669
Main Authors:	SPIES, CLAUDIA D., KISSNER, MARTINA, NEUMANN, TIM, BLUM, SUSANE, VOIGT, CHRISTIAN, FUNK, THOMAS, RUNKEL, NORBERT, PRAGST, FRITZ
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 01-11-1998
Subjects:	Adolescent Adult Alcoholism - blood Alcoholism and acute alcohol poisoning Biological and medical sciences Biomarkers - blood Critical Care Double-Blind Method Emergency Treatment Humans Male Medical sciences Middle Aged Prospective Studies Psychology. Psychoanalysis. Psychiatry Psychometrics. Diagnostic aid systems Psychopathology. Psychiatry Techniques and methods Toxicology Transferrin - analogs & derivatives Transferrin - analysis Human Transferrin Alcoholism Carbohydrate deficient protein Prediction Biological marker Duration Hospitalization Medical screening Trauma Morbidity Intensive care unit Double blind study Complication
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Summary:	Carbohydrate-deficient transferrin (CDT) is reported to have a higher specificity in alcoholism than conventional markers. As the morbidity and mortality rates amongst chronic alcoholics are raised following trauma, the objective was to investigate if CDT could be used to predict prolonged intensive care Unit (ICU) stay and an increased morbidity in patients with multiple injuries admitted to the ICU. In this prospective double-blind study, 66 traumatized male patients were transferred to the ICU following admission via the emergency room and operative management. Blood samples for CDT determination were taken upon admission to the emergency room, the ECU and on days 2 and 4 following admission. The patients were allocated a priori to two groups; high CDT group (CDT > 20 U/I on admission to the emergency room) and low CDT group (CDT ≤ 20 U/I). CDT values were determined by microanion-exchange chromatography and radioimmunoassay. Thirty-six patients had an elevated CDT value on admission to the emergency room. The high CDT group had a significantly prolonged ICU stay (median high CDT group: 13 days; median low CDT group: 5 days). Major intercurrent complications, such as alcohol-withdrawal syndrome, tracheobronchitis, pneumonia, pancreatitis, sepsis. and congestive heart failure, were significantly increased in the high CDT group The increased risk of pneumonia in the high CDT group may be related to the significantly increased period of mechanical ventilation. As high CDT values were associated with an increased risk of intercurrent complications and a prolonged ICU stay. it seems reasonable to use CDT as a marker in intensifying research work into preventing alcoholism-associated complications.
Bibliography:	istex:C48C5CF1EC3AE3BA2880EAE338BFA5D73970AE94 Author to whom correspondence should be addressed ArticleID:33.6.661 ark:/67375/HXZ-RTNKRTQH-0
ISSN:	0735-0414 1464-3502
DOI:	10.1093/alcalc/33.6.661