Search Results - "KISO, YOSHIAKI"

New directions for protease inhibitors directed drug discovery by Hamada, Yoshio, Kiso, Yoshiaki

“…ABSTRACT Proteases play crucial roles in various biological processes, and their activities are essential for all living organisms—from viruses to humans…”
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Paclitaxel Prodrugs:  Toward Smarter Delivery of Anticancer Agents by Skwarczynski, Mariusz, Hayashi, Yoshio, Kiso, Yoshiaki

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Mitocryptide-2: Identification of Its Minimum Structure for Specific Activation of FPR2-Possible Receptor Switching from FPR2 to FPR1 by Its Physiological C-terminal Cleavages by Marutani, Takayuki, Nishino, Kodai, Miyaji, Tomoyuki, Kamada, Keisuke, Ohura, Koji, Kiso, Yoshiaki, Mukai, Hidehito

“…Mitocryptides are a novel family of endogenous neutrophil-activating peptides originating from various mitochondrial proteins. Mitocryptide-2 (MCT-2) is one of…”
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The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors by Hamada, Yoshio, Kiso, Yoshiaki

“…A bioisostere is a powerful concept for medicinal chemistry. It allows the improvement of the stability; oral absorption; membrane permeability; and…”
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Molecular sieving effects of disk-shaped molecules on reverse osmosis and nanofiltration separation by Kiso, Yoshiaki, Oguchi, Tatsuo, Kamimoto, Yuki, Makino, Kazuya, Takeyoshi, Yuki, Yamada, Toshiro

“…[Display omitted] •The shape of crown ethers was approximated to be a disk.•The calculated rejections corresponded well to the observed rejection.•The…”
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Pore radius estimation based on organic solute molecular shape and effects of pressure on pore radius for a reverse osmosis membrane by Kiso, Yoshiaki, Muroshige, Kentaro, Oguchi, Tatsuo, Hirose, Masahiko, Ohara, Tomomi, Shintani, Takuji

“…▶ The shape of organic solute was represented by molecular length and width. ▶ Rejections of alcohols were successfully simulated by using the shape…”
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Effect of molecular shape on rejection of uncharged organic compounds by nanofiltration membranes and on calculated pore radii by Kiso, Yoshiaki, Muroshige, Kentaro, Oguchi, Tatsuo, Yamada, Toshiro, Hhirose, Masahiko, Ohara, Tomomi, Shintani, Takuji

“…We examined the effects of molecular shape on the rejection of uncharged organic compounds by nanofiltration membranes and on pore radii calculated for those…”
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Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl isopeptides by Sohma, Youhei, Sasaki, Masato, Hayashi, Yoshio, Kimura, Tooru, Kiso, Yoshiaki

“…A novel and efficient method for the synthesis of difficult sequence-containing peptides has been developed based on the synthesis of O-acyl isopeptides…”
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Application of the O-N intramolecular acyl migration reaction in medicinal chemistry by Skwarczynski, Mariusz, Kiso, Yoshiaki

“…The O-N intramolecular acyl migration, also named as an acyl shift or acyl transfer reaction, is well-known in organic and peptide chemistry as a simple…”
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Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography by Adachi, Motoyasu, Ohhara, Takashi, Kurihara, Kazuo, Tamada, Taro, Honjo, Eijiro, Okazaki, Nobuo, Arai, Shigeki, Shoyama, Yoshinari, Kimura, Kaname, Matsumura, Hiroyoshi, Sugiyama, Shigeru, Adachi, Hiroaki, Takano, Kazufumi, Mori, Yusuke, Hidaka, Koushi, Kimura, Tooru, Hayashi, Yoshio, Kiso, Yoshiaki, Kuroki, Ryota

“…HIV-1 protease is a dimeric aspartic protease that plays an essential role in viral replication. To further understand the catalytic mechanism and inhibitor…”
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Synthesis of O-Acyl Isopeptides by Sohma, Youhei, Kiso, Yoshiaki

“…O‐Acyl isopeptides, in which the N‐acyl linkage on the hydroxyamino acid residue (e.g., Ser and Thr) is replaced with an O‐acyl linkage, generally possess…”
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Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1 by Seki, Tetsuo, Fukamizu, Akiyoshi, Kiso, Yoshiaki, Mukai, Hidehito

“…► The cryptides, functional cryptic peptides hidden in protein structures, have become a topic of interest for the global scientific community. ► Mammalian…”
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Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study by Thanigaimalai, Pillaiyar, Konno, Sho, Yamamoto, Takehito, Koiwai, Yuji, Taguchi, Akihiro, Takayama, Kentaro, Yakushiji, Fumika, Akaji, Kenichi, Kiso, Yoshiaki, Kawasaki, Yuko, Chen, Shen-En, Naser-Tavakolian, Aurash, Schön, Arne, Freire, Ernesto, Hayashi, Yoshio

“…This work describes the design, synthesis, and evaluation of low-molecular weight peptidic SARS-CoV 3CL protease inhibitors. The inhibitors were designed based…”
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PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model by Inden, Masatoshi, Taira, Takahiro, Kitamura, Yoshihisa, Yanagida, Takashi, Tsuchiya, Daiju, Takata, Kazuyuki, Yanagisawa, Daijiro, Nishimura, Kaneyasu, Taniguchi, Takashi, Kiso, Yoshiaki, Yoshimoto, Kanji, Agatsuma, Tomohiro, Koide-Yoshida, Shizuyo, Iguchi-Ariga, Sanae M.M., Shimohama, Shun, Ariga, Hiroyoshi

“…DJ-1 has recently been shown to be responsible for onset of familial Parkinson’s disease (PD), PARK7. DJ-1 has been shown to play roles in transcriptional…”
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Mitochondrial protein-derived cryptides: Are endogenous N-formylated peptides including mitocryptide-2 components of mitochondrial damage-associated molecular patterns? by Marutani, Takayuki, Hattori, Tatsuya, Tsutsumi, Koki, Koike, Yusuke, Harada, Akihiko, Noguchi, Kosuke, Kiso, Yoshiaki, Mukai, Hidehito

“…ABSTRACT Recently, much attention has been paid to “nonclassical” bioactive peptides, which are fragmented peptides simultaneously produced during maturation…”
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Synthesis and structure–activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents by Yamazaki, Yuri, Sumikura, Makiko, Masuda, Yurika, Hayashi, Yoshiki, Yasui, Hiroyuki, Kiso, Yoshiaki, Chinen, Takumi, Usui, Takeo, Yakushiji, Fumika, Potts, Barbara, Neuteboom, Saskia, Palladino, Michael, Lloyd, George Kenneth, Hayashi, Yoshio

“…KPU-105 (4), a potent anti-microtubule agent that contains a benzophenone was derived from the diketopiperazine-type vascular disrupting agent (VDA) plinabulin…”
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Compensating Enthalpic and Entropic Changes Hinder Binding Affinity Optimization by Lafont, Virginie, Armstrong, Anthony A., Ohtaka, Hiroyasu, Kiso, Yoshiaki, Mario Amzel, L., Freire, Ernesto

“…A common strategy to improve the potency of drug candidates is to introduce chemical functionalities, like hydrogen bond donors or acceptors, at positions…”
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Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum by Bhaumik, Prasenjit, Horimoto, Yasumi, Xiao, Huogen, Miura, Takuya, Hidaka, Koushi, Kiso, Yoshiaki, Wlodawer, Alexander, Yada, Rickey Y., Gustchina, Alla

“…Plasmepsin I (PMI) is one of the four vacuolar pepsin-like proteases responsible for hemoglobin degradation by the malarial parasite Plasmodium falciparum, and…”
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Development of O-acyl isopeptide method by Sohma, Youhei, Yoshiya, Taku, Taniguchi, Atsuhiko, Kimura, Tooru, Hayashi, Yoshio, Kiso, Yoshiaki

“…During over a decade of study on aspartic protease inhibitors and water‐soluble prodrugs, in 2003, we discovered that the presence of an O‐acyl instead of…”
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Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design by Hamada, Yoshio, Tagad, Harichandra D., Nishimura, Yoshinori, Ishiura, Shoichi, Kiso, Yoshiaki

“…Previously reported pentapeptidic BACE1 inhibitors, designed using a substrate-based approach, were used as lead compounds for the further design of…”
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