Search Results - "KIRSCHMANN, Guylène"
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Characterisation of GFAP-Expressing Glial Cells in the Dorsal Root Ganglion after Spared Nerve Injury
Published in International journal of molecular sciences (01-11-2023)“…Satellite glial cells (SGCs), enveloping primary sensory neurons' somas in the dorsal root ganglion (DRG), contribute to neuropathic pain upon nerve injury…”
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2
Reversing anterior insular cortex neuronal hypoexcitability attenuates compulsive behavior in adolescent rats
Published in Proceedings of the National Academy of Sciences - PNAS (24-05-2022)“…Development of self-regulatory competencies during adolescence is partially dependent on normative brain maturation. Here, we report that adolescent rats as…”
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3
Potassium channel modulation in macrophages sensitizes dorsal root ganglion neurons after nerve injury
Published in Glia (01-04-2024)“…Macrophages and satellite glial cells are found between injured and uninjured neurons in the lumbar dorsal root ganglia (DRG). We explored the mechanism of…”
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Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain
Published in The Journal of clinical investigation (01-07-2013)“…Peripheral neuropathic pain is a disabling condition resulting from nerve injury. It is characterized by the dysregulation of voltage-gated sodium channels…”
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Neuropathic Pain Phenotype Does Not Involve the NLRP3 Inflammasome and Its End Product Interleukin-1β in the Mice Spared Nerve Injury Model
Published in PloS one (28-07-2015)“…The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is one of the main sources of interleukin-1β (IL-1β) and is involved in several…”
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Spinal Cord T-Cell Infiltration in the Rat Spared Nerve Injury Model: A Time Course Study
Published in International journal of molecular sciences (09-03-2016)“…The immune system is involved in the development of neuropathic pain. In particular, the infiltration of T-lymphocytes into the spinal cord following…”
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Rufinamide Attenuates Mechanical Allodynia in a Model of Neuropathic Pain in the Mouse and Stabilizes Voltage-gated Sodium Channel Inactivated State
Published in Anesthesiology (Philadelphia) (2013)“…Voltage-gated sodium channels dysregulation is important for hyperexcitability leading to pain persistence. Sodium channel blockers currently used to treat…”
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The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel NaV1.7 via the Ubiquitin-Ligase NEDD4-2
Published in eNeuro (01-03-2022)“…The antidiabetic drug metformin has been shown to reduce pain hypersensitivity in preclinical models of chronic pain and in neuropathic pain in humans…”
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Neuropathic Pain Phenotype Does Not Involve the NLRP3 Inflammasome and Its End Product Interleukin-1[beta] in the Mice Spared Nerve Injury Model
Published in PloS one (28-07-2015)“…The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is one of the main sources of interleukin-1[beta] (IL-1[beta]) and is involved in…”
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The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel Na V 1.7 via the Ubiquitin-Ligase NEDD4-2
Published in eNeuro (01-03-2022)“…The antidiabetic drug metformin has been shown to reduce pain hypersensitivity in preclinical models of chronic pain and in neuropathic pain in humans…”
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Neuropathic Pain Phenotype Does Not Involve the NLRP3 Inflammasome and Its End Product Interleukin-1 beta in the Mice Spared Nerve Injury Model: e0133707
Published in PloS one (01-07-2015)“…The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is one of the main sources of interleukin-1 beta (IL-1 beta ) and is involved in…”
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