Search Results - "KIRKUP, D."

Rationally targeted anti-VISTA antibody that blockades the C-C’ loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner by Thakkar, Dipti, Paliwal, Shalini, Dharmadhikari, Bhushan, Guan, Siyu, Liu, Lillian, Kar, Shreya, Tulsian, Nikhil K, Gruber, Joshua J, DiMascio, Leah, Paszkiewicz, Konrad H, Ingram, Piers J, D Boyd-Kirkup, Jerome

“…BackgroundDespite significant progress in cancer immunotherapy in recent years, resistance to existing immune checkpoint therapies (ICT) is common. V-domain Ig…”
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Stress‐associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain by Han, Yixing, Han, Dali, Yan, Zheng, Boyd‐Kirkup, Jerome D., Green, Christopher D., Khaitovich, Philipp, Han, Jing‐Dong J.

“…Summary Epigenetic modifications are critical determinants of cellular and developmental states. Epigenetic changes, such as decreased H3K27me3 histone…”
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The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A by Dou, Xiaoyang, Boyd-Kirkup, Jerome D, McDermott, Joseph, Zhang, Xiaoli, Li, Fang, Rong, Bowen, Zhang, Rui, Miao, Bisi, Chen, Peilin, Cheng, Hao, Xue, Jianhuang, Bennett, David, Wong, Jiemin, Lan, Fei, Han, Jing-Dong J

“…How individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite…”
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A Preliminary Study of Genetic Variation in Populations of Monstera adansonii var. klotzschiana (Araceae) from North-East Brazil, Estimated with AFLP Molecular Markers by Andrade, I. M., Mayo, S. J., van den Berg, C., Fay, M. F., Chester, M., Lexer, C., Kirkup, D.

“…Background and Aims This study sought genetic evidence of long-term isolation in populations of Monstera adansonii var. klotzschiana (Araceae), a herbaceous,…”
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The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody by Chan, Conrad E. Z, Seah, Shirley G. K, Chye, De Hoe, Massey, Shane, Torres, Maricela, Lim, Angeline P. C, Wong, Steven K. K, Neo, Jacklyn J. Y, Wong, Pui San, Lim, Jie Hui, Loh, Gary S. L, Wang, Dongling, Boyd-Kirkup, Jerome D, Guan, Siyu, Thakkar, Dipti, Teo, Guo Hui, Purushotorman, Kiren, Hutchinson, Paul E, Young, Barnaby E, Low, Jenny G, MacAry, Paul A, Hentze, Hannes, Prativadibhayankara, Venkateshan S, Ethirajulu, Kantharaj, Comer, Jason E, Tseng, Chien-Te K, Barrett, Alan D. T, Ingram, Piers J, Brasel, Trevor, Hanson, Brendon John

“…Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-19, little is known about their mechanism(s) of action or effective dosing…”
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10D1F, an Anti-HER3 Antibody that Uniquely Blocks the Receptor Heterodimerization Interface, Potently Inhibits Tumor Growth Across a Broad Panel of Tumor Models by Thakkar, Dipti, Sancenon, Vicente, Taguiam, Marvin M, Guan, Siyu, Wu, Zhihao, Ng, Eric, Paszkiewicz, Konrad H, Ingram, Piers J, Boyd-Kirkup, Jerome D

“…In recent years, HER3 has increasingly been implicated in the progression of a variety of tumor types and in acquired resistance to EGFR and HER2 therapies…”
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Plant collecting spread and densities: their potential impact on biogeographical studies in Thailand by Parnell, J. A. N., Simpson, D. A., Moat, J., Kirkup, D. W., Chantaranothai, P., Boyce, P. C., Bygrave, P., Dransfield, S., Jebb, M. H. P., Macklin, J., Meade, C., Middleton, D. J., Muasya, A. M., Prajaksood, A., Pendry, C. A., Pooma, R., Suddee, S., Wilkin, P.

“…Aims To produce representative aggregate maps of plant collection locations in Thailand and discuss their impact on biogeographical studies in Thailand and the…”
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Alpha E-Taxonomy: Responses from the Systematics Community to the Biodiversity Crisis by Mayo, S. J., Allkin, R., Baker, W., Blagoderov, V., Brake, I., Clark, B., Govaerts, R., Godfray, C., Haigh, A., Hand, R., Harman, K., Jackson, M., Kilian, N., Kirkup, D. W., Kitching, I., Knapp, S., Lewis, G. P., Malcolm, P., von Raab-Straube, E., Roberts, D. M., Scoble, M., Simpson, D. A., Smith, C., Smith, V., Villalba, S., Walley, L., Wilkin, P.

“…The crisis facing the conservation of biodiversity is reflected in a parallel crisis in alpha taxonomy. On one hand, there is an acute need from government and…”
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Mammalian mitochondrial nucleoids: organizing an independently minded genome by Holt, Ian J, He, Jiuya, Mao, Chih-Chieh, Boyd-Kirkup, Jerome D, Martinsson, Peter, Sembongi, Hiroshi, Reyes, Aurelio, Spelbrink, Johannes N

“…Mitochondrial DNA is arranged in nucleoprotein complexes, or nucleoids. Nucleoid proteins include not only factors involved in replication and transcription…”
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Single-cell-level spatial gene expression in the embryonic neural differentiation niche by Huang, Yi, Yu, Xiaoming, Sun, Na, Qiao, Nan, Cao, Yaqiang, Boyd-Kirkup, Jerome D, Shen, Qin, Han, Jing-Dong J

“…With the rapidly increasing availability of high-throughput in situ hybridization images, how to effectively analyze these images at high resolution for global…”
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Epigenomics and the regulation of aging by Boyd-Kirkup, Jerome D, Green, Christopher D, Wu, Gang, Wang, Dan, Han, Jing-Dong J

“…It is tempting to assume that a gradual accumulation of damage 'causes' an organism to age, but other biological processes present during the lifespan, whether…”
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The global spectrum of plant form and function by Díaz, Sandra, Kattge, Jens, Cornelissen, Johannes H. C., Wright, Ian J., Lavorel, Sandra, Dray, Stéphane, Reu, Björn, Kleyer, Michael, Wirth, Christian, Colin Prentice, I., Garnier, Eric, Bönisch, Gerhard, Westoby, Mark, Poorter, Hendrik, Reich, Peter B., Moles, Angela T., Dickie, John, Gillison, Andrew N., Zanne, Amy E., Chave, Jérôme, Joseph Wright, S., Sheremet’ev, Serge N., Jactel, Hervé, Baraloto, Christopher, Cerabolini, Bruno, Pierce, Simon, Shipley, Bill, Kirkup, Donald, Casanoves, Fernando, Joswig, Julia S., Günther, Angela, Falczuk, Valeria, Rüger, Nadja, Mahecha, Miguel D., Gorné, Lucas D.

“…Earth is home to a remarkable diversity of plant forms and life histories, yet comparatively few essential trait combinations have proved evolutionarily viable…”
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accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells by Di Re, M, Sembongi, H, He, J, Reyes, A, Yasukawa, T, Martinsson, P, Bailey, L.J, Goffart, S, Boyd-Kirkup, J.D, Wong, T.S, Fersht, A.R, Spelbrink, J.N, Holt, I.J

“…The accessory subunit of mitochondrial DNA polymerase γ, POLGβ, functions as a processivity factor in vitro. Here we show POLGβ has additional roles in…”
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First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults by Prativadibhayankaram, Venkateshan S., Lee, Lawrence Soon-U, Lye, David, Xiaoying, Xu, Nellore, Ranjani, Pendharkar, Vishal, Hentze, Hannes, Guan, Siyu, Ayers, Benjamin J., Seah, Shirley G. K., Chye, De Hoe, Talib, Najwa S. N., Kaliaperumal, Nivashini, Ong, Wei Yee, Wong, Zi Xin, Au, Veonice B., Alok, Anshula, Connolly, John E., Boyd-Kirkup, Jerome D., Ingram, Piers J., Hanson, Brendon J., Ethirajulu, Kantharaj, O’Connell, Damian, Chan, Conrad E. Z.

“…Introduction AOD01 is a novel, fully human immunoglobulin (Ig) G1 neutralizing monoclonal antibody that was developed as a therapeutic against severe acute…”
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The African key project: Gateway to African plants by Victor, J.E., Kirkup, D.

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Elliptic Fourier Analysis of leaf outlines in five species of Heteropsis (Araceae) from the Reserva Florestal Adolpho Ducke, Manaus, Amazonas, Brazil by Soares, M. L. C., Mayo, S. J., Gribel, R., Kirkup, D.

“…A pilot study of leaf outline morphometrics was carried out on populations of five species of Heteropsis located in the Reserva Florestal Adolpho Ducke near…”
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Elliptic Fourier Analysis of leaf outline shape in forest fragment populations of Anthurium sinuatum and A. pentaphyllum (Araceae) from Northeast Brazil by Andrade, I. M., Mayo, S. J., Kirkup, D., Van den Berg, C.

“…A field-based comparative study of leaflet outline shape in five populations of Anthurium sinuatum Benth. ex Schott from Amazonia and humid brejo forests of…”
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Comparative Morphology of Populations of Monstera Adans. (Araceae) from Natural Forest Fragments in Northeast Brazil Using Elliptic Fourier Analysis of Leaf Outlines by Andrade, I. M., Mayo, S. J., Kirkup, D., Van Den Berg, C.

“…A comparative study of the leaf outline morphometrics of Monstera adansonii var. klotzschiana, M. adansonii var. laniata and M. praetermissa was carried out…”
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Lucid Professional Version 2.0: tools for identification and diagnosis. Centre for Pest Information Technology & Transfer by Kirkup, D.

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Abstract 24: HMBD001, a novel anti-ErbB3 antibody with a unique mechanism of action, effectively inhibits tumor growth in pre-clinical models of ErbB3+ solid tumors by Boyd-Kirkup, Jerome D., Thakkar, Dipti, Ingram, Piers J.

“…Abstract Gastric cancer is the second highest cause of cancer mortality in Asia. Over-expression of ErbB3, a cell surface RTK, occurs in ~60% of mGC patients…”
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