Search Results - "KIRIAKIDOU, Marianthi"

A combined computational-experimental approach predicts human microRNA targets by Kiriakidou, Marianthi, Nelson, Peter T, Kouranov, Andrei, Fitziev, Petko, Bouyioukos, Costas, Mourelatos, Zissimos, Hatzigeorgiou, Artemis

“…A new paradigm of gene expression regulation has emerged recently with the discovery of microRNAs (miRNAs). Most, if not all, miRNAs are thought to control…”
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A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells by Nelson, Peter T, De Planell-Saguer, Mariangels, Lamprinaki, Stella, Kiriakidou, Marianthi, Zhang, Paul, O'Doherty, Una, Mourelatos, Zissimos

“…Argonaute (Ago) proteins bind to microRNA (miRNAs) and short interfering RNAs (siRNAs) and form the core components of effector complexes that mediate miRNA…”
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Systemic Lupus Erythematosus by Kiriakidou, Marianthi, Ching, Cathy Lee

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Granulomatosis with polyangiitis masquerading as pituitary adenoma with apoplexy by Piper, Keenan, Beldick, Stephanie R, Karsy, Michael, Allawh, Tanya, Shirodkar, Monika, Miller, Jeffrey, Kiriakidou, Marianthi, Curtis, Mark, Evans, James J

“…Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, is a small- and medium-vessel autoimmune vasculitis. Rare presentations of…”
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Clarifying mammalian RISC assembly in vitro by Tan, Grace S, Garchow, Barry G, Liu, Xuhang, Metzler, David, Kiriakidou, Marianthi

“…Argonaute, the core component of the RNA induced silencing complex (RISC), binds to mature miRNAs and regulates gene expression at transcriptional or…”
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MicroRNA-21 deficiency protects from lupus-like autoimmunity in the chronic graft-versus-host disease model of systemic lupus erythematosus by Garchow, Barry, Kiriakidou, Marianthi

“…Abstract MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression primarily at the post-transcriptional level. Emerging evidence supports a…”
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Steroidogenic Factor 1-Dependent Promoter Activity of the Human Steroidogenic Acute Regulatory Protein (StAR) Gene by Sugawara, Teruo, Holt, John A, Kiriakidou, Marianthi, Strauss, Jerome F

“…Steroidogenic acute regulatory protein (StAR) is required for efficient adrenal cortical and gonadal but not trophoblast steroid hormone synthesis. StAR gene…”
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Multiple Steroidogenic Factor 1 Binding Elements in the Human Steroidogenic Acute Regulatory Protein Gene 5‘-Flanking Region Are Required for Maximal Promoter Activity and Cyclic AMP Responsiveness by Sugawara, Teruo, Kiriakidou, Marianthi, McAllister, Jan M, Kallen, Caleb B, Strauss, Jerome F

“…A proximal element from the human StAR gene promoter, containing the sequence -105TATCCTTGAC-95, was shown to confer responsiveness to 8-Br-cAMP in the…”
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HIF-1α and miR-210 differential and lineage-specific expression in systemic lupus erythematosus by Garchow, Barry, Maque Acosta, Yvan, Kiriakidou, Marianthi

“…•A key role for HIF-1α has been described in autoimmune and inflammatory diseases with diverse pathologies but remains unexplored in SLE.•MiR-210 expression in…”
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Sperm Antigen 6 Is the Murine Homologue of the Chlamydomonas reinhardtii Central Apparatus Protein Encoded by the PF16 Locus by SAPIRO, R, TARANTINO, L. M, VELAZQUEZ, F, KIRIAKIDOU, M, HECHT, N. B, BUCAN, M, STRAUSS, J. F

“…A cDNA encoding sperm antigen 6 (Spag6), the murine homologue of the Chlamydomonas reinhardtii PF16 protein—a component of the flagella central…”
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Systemic lupus erythematosus by Kiriakidou, Marianthi, Cotton, Deborah, Taichman, Darren, Williams, Sankey

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Regulation of expression of the steroidogenic acute regulatory protein (StAR) gene: A central role for steroidogenic factor 1 by Sugawara, Teruo, Kiriakidou, Marianthi, McAllister, Jan M., Holt, John A., Arakane, Futoshi, Strauss, Jerome F.

“…Steroidogenic acute regulatory protein (StAR) plays a critical role Xin regulating the rate-limiting step in steroid hormone synthesis, cholesterol side-chain…”
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Silencing of microRNA‐21 in vivo ameliorates autoimmune splenomegaly in lupus mice by Garchow, Barry G., Bartulos Encinas, Oscar, Leung, Yiu Tak, Tsao, Patricia Y., Eisenberg, Robert A., Caricchio, Roberto, Obad, Susanna, Petri, Andreas, Kauppinen, Sakari, Kiriakidou, Marianthi

“…MicroRNAs (miRNAs) have been implicated in B cell lineage commitment, regulation of T cell differentiation, TCR signalling, regulation of IFN signalling, and…”
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The microRNA world: small is mighty by Nelson, Peter, Kiriakidou, Marianthi, Sharma, Anup, Maniataki, Elsa, Mourelatos, Zissimos

“…A new paradigm of RNA-directed gene expression regulation has emerged recently, profound in scope but arresting in the apparent simplicity of its core…”
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Small Molecule Inhibition of RISC Loading by Tan, Grace S, Chiu, Chun-Hao, Garchow, Barry G, Metzler, David, Diamond, Scott L, Kiriakidou, Marianthi

“…Argonaute proteins are the core components of the microRNP/RISC. The biogenesis and function of microRNAs and endo- and exo- siRNAs are regulated by Ago2, an…”
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In the Clinic: Systemic Lupus Erythematosus by KIRIAKIDOU, Marianthi, COTTON, Deborah, TAICHMAN, Darren, WILLIAMS, Sankey

“…Systemic lupus erythematosus (SLE, lupus) is a condition in which the immune system attacks healthy cells and tissues throughout the body. Immune system…”
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Expanded RNA-binding activities of mammalian Argonaute 2 by Tan, Grace S, Garchow, Barry G, Liu, Xuhang, Yeung, Jennifer, Morris, John P. IV, Cuellar, Trinna L, McManus, Michael T, Kiriakidou, Marianthi

“…Mammalian Argonaute 2 (Ago2) protein associates with microRNAs (miRNAs) or small interfering RNAs (siRNAs) forming RNA-induced silencing complexes…”
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Localization of the Steroidogenic Acute Regulatory Protein in Human Tissues1 by Pollack, Staci E, Furth, Emma E, Kallen, Caleb B, Arakane, Futoshi, Kiriakidou, Marianthi, Kozarsky, Karen F, Strauss, Jerome F

“…The rate-limiting step in steroid hormone production in the adrenal cortex and gonads, the translocation of cholesterol from the outer to the inner…”
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Two interesting cases of intracranial IgG4-related disease and discussion of therapy options by Fortuna, Danielle, Mardekian, Stacey K, Garchow, Barry, Evans, James, Kiriakidou, Marianthi, Curtis, Mark T

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High-throughput experimental studies to identify miRNA targets directly, with special focus on the mammalian brain by Nelson, Peter T, Kiriakidou, Marianthi, Mourelatos, Zissimos, Tan, Grace S, Jennings, Mary H, Xie, Kevin, Wang, Wang-Xia

“…Abstract We review the pertinent literature on methods used in high-throughput experimental identification of microRNA (miRNA) “targets” with emphasis on…”
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