Search Results - "KIRCHNER, Hartmut"

Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia by THOL, Felicitas, DAMM, Frederik, LÜBBERT, Michael, KANZ, Lothar, FIEDLER, Walter, KIRCHNER, Hartmut, HEIL, Gerhard, KRAUTER, Jürgen, GANSER, Arnold, HEUSER, Michael, LÜDEKING, Andrea, WINSCHEL, Claudia, WAGNER, Katharina, MORGAN, Michael, HAIYANG YUN, GÖHRING, Gudrun, SCHLEGELBERGER, Brigitte, HOELZER, Dieter

“…To study the incidence and prognostic impact of mutations in DNA methyltransferase 3A (DNMT3A) in patients with acute myeloid leukemia. A total of 489 patients…”
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Impact of IDH1 R132 Mutations and an IDH1 Single Nucleotide Polymorphism in Cytogenetically Normal Acute Myeloid Leukemia: SNP rs11554137 Is an Adverse Prognostic Factor by Wagner, Katharina, Damm, Frederik, Göhring, Gudrun, Görlich, Kerstin, Heuser, Michael, Schäfer, Irina, Ottmann, Oliver, Lübbert, Michael, Heit, Wolfgang, Kanz, Lothar, Schlimok, Günter, Raghavachar, Aruna A, Fiedler, Walter, Kirchner, Hartmut H, Brugger, Wolfram, Zucknick, Manuela, Schlegelberger, Brigitte, Heil, Gerhard, Ganser, Arnold, Krauter, Jürgen

“…We assessed the prognostic impact of IDH1 R132 mutations and a known single nucleotide polymorphism (SNP) located in the same exon of the IDH1 gene in patients…”
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Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia by Thol, Felicitas, Damm, Frederik, Wagner, Katharina, Göhring, Gudrun, Schlegelberger, Brigitte, Hoelzer, Dieter, Lübbert, Michael, Heit, Wolfgang, Kanz, Lothar, Schlimok, Günter, Raghavachar, Aruna, Fiedler, Walter, Kirchner, Hartmut, Heil, Gerhard, Heuser, Michael, Krauter, Jürgen, Ganser, Arnold

“…Mutations in the nicotinamide adenine dinucleotide phosphate+–dependent isocitrate dehydrogenase gene 2 (IDH2) have recently been found in patients with acute…”
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Single Nucleotide Polymorphism in the Mutational Hotspot of WT1 Predicts a Favorable Outcome in Patients With Cytogenetically Normal Acute Myeloid Leukemia by DAMM, Frederik, HEUSER, Michael, HEIT, Wolfgang, KANZ, Lothar, SCHLIMOK, Günter, RAGHAVACHAR, Aruna, FIEDLER, Walter, KIRCHNER, Hartmut, DÖHNER, Hartmut, HEIL, Gerhard, GANSER, Arnold, KRAUTER, Jürgen, MORGAN, Michael, HAIYANG YUN, GROSSHENNIG, Anika, GOHRING, Gudrun, SCHLEGELBERGER, Brigitte, DÖHNER, Konstanze, OTTMANN, Oliver, LÜBBERT, Michael

“…We assessed the prognostic impact of a known single nucleotide polymorphism (SNP) located in the mutational hotspot of WT1 in patients with cytogenetically…”
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Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia by Hehlmann, Rüdiger, Berger, Ute, Pfirrmann, Markus, Heimpel, Hermann, Hochhaus, Andreas, Hasford, Joerg, Kolb, Hans-Jochem, Lahaye, Tanja, Maywald, Ole, Reiter, Andreas, Hossfeld, Dieter K., Huber, Christoph, Löffler, Helmut, Pralle, Hans, Queisser, Wolfgang, Tobler, Andreas, Nerl, Christoph, Solenthaler, Max, Goebeler, Mariele E., Griesshammer, Martin, Fischer, Thomas, Kremers, Stephan, Eimermacher, Hartmut, Pfreundschuh, Michael, Hirschmann, Wolf-Dietrich, Lechner, Klaus, Wassmann, Barbara, Falge, Christiane, Kirchner, Hartmut H., Gratwohl, Alois

“…Early allogeneic hematopoietic stem cell transplantation (HSCT) has been proposed as primary treatment modality for patients with chronic myeloid leukemia…”
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Autoimmunity Resulting From Cytokine Treatment Predicts Long-Term Survival in Patients With Metastatic Renal Cell Cancer by FRANZKE, A, PEEST, D, PROBST-KEPPER, M, BUER, J, KIRCHNER, G. I, BRABANT, G, KIRCHNER, H, GANSER, A, ATZPODIEN, J

“…In patients undergoing cytokine therapy, systemically applied interleukin-2 (IL-2) and/or interferon-alpha (IFN-alpha) have been reported to induce thyroid…”
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A randomized comparison of immediate versus delayed application of G-CSF in induction therapy for patients with acute myeloid leukemia unfit for intensive chemotherapy by von Lilienfeld-Toal, Marie, Hahn-Ast, Corinna, Kirchner, Hartmut, Flieger, Dimitri, Dolken, Gottfried, Glasmacher, Axel

“…* Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn, Bonn; ° Klinikum Region Hannover, Siloah, Medizinische Klinik III, Hannover; # GPR Klinikum,…”
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Rapidly Alternating COPP/ABV/IMEP Is Not Superior to Conventional Alternating COPP/ABVD in Combination With Extended-Field Radiotherapy in Intermediate-Stage Hodgkin’s Lymphoma: Final Results of the German Hodgkin’s Lymphoma Study Group Trial HD5 by Sieber, M.

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Reduced Treatment Intensity in Patients with Early-Stage Hodgkin's Lymphoma by Engert, Andreas, Plütschow, Annette, Eich, Hans Theodor, Lohri, Andreas, Dörken, Bernd, Borchmann, Peter, Berger, Bernhard, Greil, Richard, Willborn, Kay C, Wilhelm, Martin, Debus, Jürgen, Eble, Michael J, Sökler, Martin, Ho, Antony, Rank, Andreas, Ganser, Arnold, Trümper, Lorenz, Bokemeyer, Carsten, Kirchner, Hartmut, Schubert, Jörg, Král, Zdenek, Fuchs, Michael, Müller-Hermelink, Hans-Konrad, Müller, Rolf-Peter, Diehl, Volker

“…Investigators examined whether the intensity of treatment can be reduced in patients with early-stage Hodgkin's lymphoma without compromising antitumor…”
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Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells by Schwab, Ulrich, Stein, Harald, Gerdes, Johannes, Lemke, Hilmar, Kirchner, Hartmut, Schaadt, Michael, Diehl, Volker

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Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial by Schmitz, Norbert, Pfistner, Beate, Sextro, Michael, Sieber, Markus, Carella, Angelo M, Haenel, Matthias, Boissevain, Friederike, Zschaber, Reinhart, Müller, Peter, Kirchner, Hartmut, Lohri, Andreas, Decker, Susanne, Koch, Bettina, Hasenclever, Dirk, Goldstone, Anthony H, Diehl, Volker

“…High-dose chemotherapy followed by transplantation of autologous haemopoietic stem cells (BEAMHSCT) is frequently used to treat patients with relapsed…”
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IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells by Paine, Ananta, Kirchner, Hartmut, Immenschuh, Stephan, Oelke, Mathias, Blasczyk, Rainer, Eiz-Vesper, Britta

“…The glycoprotein CD86 is an important costimulatory molecule that has been shown to be predominantly expressed on APCs, such as dendritic cells, macrophages,…”
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Circulating Tumor Cells As a Surrogate Marker for Bone Marrow Minimal Residual Disease and an Adverse Prognostic Factor for Patients with Multiple Myelom by Huhn, Stefanie, Hänel, Mathias, Hielscher, Thomas, Bertsch, Uta, Salwender, Hans Jürgen, Peter, Norma, Kirchner, Hartmut, Bernhard, Helga, Vogel, Martin, Angermund, Ralf, Goerner, Martin, Weisel, Katja C., Duering, Jan, Blau, Igor W, Weinhold, Niels, Goldschmidt, Hartmut

“…Introduction Minimal residual disease (MRD) negativity is a strong positive prognostic factor for Multiple Myeloma (MM). Consequently, the international…”
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Frequency and Clinical Characteristics Associated with Putative CAR Targets ADGRE2, CCR1, CD70, and LILRB2 in Acute Myeloid Leukemia by Shahswar, Rabia, Kloos, Arnold, Gabdoulline, Razif, Mohanty, Sagarajit, Koenecke, Christian, Wichmann, Martin, Neziri, Blerina, Klement, Piroska, Schiller, Johannes, Klesse, Sabrina, Liebich, Alessandro, Lai, Courteney, Krauter, Jürgen, Trummer, Arne, Fiedler, Walter, Kirchner, Hartmut, Heil, Gerhard, Li, Zhixiong, Hambach, Lothar, Ganser, Arnold, Thol, Felicitas, Heuser, Michael

“…Background: ADGRE2, CCR1, CD70, and LILRB2 expressed on the surface of myeloid blasts but not normal hematopoietic stem cells, T cells or other tissues have…”
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Prognostic significance of expression levels of stem cell regulators MSI2 and NUMB in acute myeloid leukemia by Thol, Felicitas, Winschel, Claudia, Sonntag, Ann-Kathrin, Damm, Frederik, Wagner, Katharina, Chaturvedi, Anuhar, Göhring, Gudrun, Schlegelberger, Brigitte, Lübbert, Michael, Fiedler, Walter, Kirchner, Hartmut, Krauter, Jürgen, Ganser, Arnold, Heuser, Michael

“…Deregulation of the hematopoietic stem cell (HSC) compartment represents a hallmark of acute myeloid leukemia (AML). Recently, in vivo screening for genes that…”
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Patient-based strategy for systemic treatment of metastatic renal cell carcinoma by Kirchner, Hartmut, Strumberg, Dirk, Bahl, Amit, Overkamp, Friedrich

“…There were only a few options 3 years ago to treat metastatic renal cell carcinoma (mRCC), a disease with a very poor prognosis. With the approval of targeted…”
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The hypomorphic TERT A1062T variant is associated with increased treatment-related toxicity in acute myeloid leukemia by Both, Anna, Krauter, Jürgen, Damm, Frederik, Thol, Felicitas, Göhring, Gudrun, Heuser, Michael, Ottmann, Oliver, Lübbert, Michael, Wattad, Mohammed, Kanz, Lothar, Schlimok, Günter, Raghavachar, Aruna, Fiedler, Walter, Kirchner, Hartmut, Brugger, Wolfram, Schlegelberger, Brigitte, Heil, Gerhard, Ganser, Arnold, Wagner, Katharina

“…Hypomorphic germline variants in TERT , the gene encoding the reverse transcriptase component of the human telomerase complex, occur with a frequency of 3–5%…”
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Characteristics and Prognosis of AML Patients with or without a History of Clonal Hematopoiesis by Thol, Felicitas, Köhler, Larissa, Klesse, Sabrina, Gabdoulline, Razif, Kloos, Arnold, Liebich, Alessandro, Wichmann, Martin, Chaturvedi, Anuhar, Fabisch, Jana, Gaidzik, Verena I., Paschka, Peter, Bullinger, Lars, Bug, Gesine, Serve, Hubert, Göhring, Gudrun, Schlegelberger, Brigitte, Luebbert, Michael, Kirchner, Hartmut H., Wattad, Mohammad Amen, Kraemer, Doris, Hertenstein, Bernd, Heil, Gerhard, Fiedler, Walter, Krauter, Juergen, Schlenk, Richard F., Döhner, Konstanze, Döhner, Hartmut, Ganser, Arnold, Heuser, Michael

“…Background: Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the detection of mutations in genes like DNA methyltransferase 3A (DNMT3A) and…”
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Impact of Age and Midostaurin-Dose on Response and Outcome in Acute Myeloid Leukemia with FLT3-ITD: Interim-Analyses of the AMLSG 16-10 Trial by Schlenk, Richard F., Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Thol, Felicitas, Kündgen, Andrea, Kindler, Thomas, Salwender, Hans-Juergen, Lübbert, Michael, Brossart, Peter, Westermann, Jörg, Kraemer, Doris, Goetze, Katharina, Horst, Heinz-August, Krauter, Jürgen, Girschikofsky, Michael, Ringhoffer, Mark, Südhoff, Thomas, Held, Gerhard, Kirchner, Hartmut H., Schmiegel, Wolff, Greil, Richard, Griesshammer, Martin, Lange, Elisabeth, Martens, Uwe, Hertenstein, Bernd, de Wit, Maike, Koller, Elisabeth, Petzer, Andreas L., Hesse, Tanja, Runde, Volker, Reimer, Peter, Schultheis, Beate S., Kirchen, Heinz, Griesinger, Frank, Hebart, Holger, Heil, Gerhard, Kremers, Stephan, Nachbaur, David, Basara, Nadezda, Schwänen, Carsten, Schöndube, Daniel, Greiner, Jochen, Münnich, Anja, Weber, Daniela, Gaidzik, Verena I., Teleanu, Maria-Veronica, Paschka, Peter, Theis, Frauke, Benner, Axel, Heuser, Michael, Döhner, Konstanze, Ganser, Arnold, Döhner, Hartmut

“…Background: Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in roughly 25% of younger adult patients (pts) with acute myeloid…”
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Impact of Donor Type on Outcome after Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia Patients: Analysis of the German-Austrian Acute Myeloid Leukemia Study Group (AMLSG) by Kuchenbauer, Florian, Bunjes, Donald W., Herr, Wolfgang, Heuser, Michael, Späth, Daniela, Casper, Jochen, Horst, Heinz-August, Brossart, Peter, Held, Gerhard, Kobbe, Guido, Ringhoffer, Mark, Wattad, Mohammed, Salih, Helmut R, Götze, Katharina, Wulf, Gerald, Theobald, Matthias, Rummel, Mathias J, Fiedler, Walter, Westermann, Jörg, Salwender, Hans, Petzer, Andreas L., Hartmann, Frank, Lübbert, Michael, Martens, Uwe, Greil, Richard, Kirchner, Hartmut H., Paschka, Peter, Gaidzik, Verena I., Teleanu, Veronica, Thol, Felicitas, Göhring, Gudrun, Döhner, Konstanze, Ganser, Arnold, Döhner, Hartmut, Schlenk, Richard F.

“…Background:Despite recent advances in identifying novel molecular targets in AML patients, intensive chemotherapy followed by allogeneic hematopoietic stem…”
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