Search Results - "KIPRIANOVA, Irina"

Oncolytic H-1 Parvovirus Shows Safety and Signs of Immunogenic Activity in a First Phase I/IIa Glioblastoma Trial by Geletneky, Karsten, Hajda, Jacek, Angelova, Assia L., Leuchs, Barbara, Capper, David, Bartsch, Andreas J., Neumann, Jan-Oliver, Schöning, Tilman, Hüsing, Johannes, Beelte, Birgit, Kiprianova, Irina, Roscher, Mandy, Bhat, Rauf, von Deimling, Andreas, Brück, Wolfgang, Just, Alexandra, Frehtman, Veronika, Löbhard, Stephanie, Terletskaia-Ladwig, Elena, Fry, Jeremy, Jochims, Karin, Daniel, Volker, Krebs, Ottheinz, Dahm, Michael, Huber, Bernard, Unterberg, Andreas, Rommelaere, Jean

“…Oncolytic virotherapy may be a means of improving the dismal prognosis of malignant brain tumors. The rat H-1 parvovirus (H-1PV) suppresses tumors in…”
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Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner by Kiprianova, Irina, Remy, Janina, Milosch, Nelli, Mohrenz, Isabelle V, Seifert, Volker, Aigner, Achim, Kögel, Donat

“…Abstract The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is overactivated in malignant glioma and plays a key…”
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Brain-Derived Neurotrophic Factor Improves Long-Term Potentiation and Cognitive Functions after Transient Forebrain Ischemia in the Rat by Kiprianova, Irina, Sandkühler, Jürgen, Schwab, Stefan, Hoyer, Siegfried, Spranger, Matthias

“…We investigated the effect of brain-derived neurotrophic factor (BDNF) on hippocampal long-term potentiation (LTP) and cognitive functions after global…”
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Fluorescence In Situ Hybridization (FISH) Detection of Viral Nucleic Acids in Oncolytic H-1 Parvovirus-Treated Human Brain Tumors by Kiprianova, Irina, Just, Alexandra, Leuchs, Barbara, Rommelaere, Jean, Angelova, Assia L

“…Fluorescence in situ hybridization (FISH) is a specific, sensitive, accurate, and reliable technique widely applied in both research and clinic. Here we…”
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Oncolytic parvoviruses as cancer therapeutics by Rommelaere, Jean, Geletneky, Karsten, Angelova, Assia L, Daeffler, Laurent, Dinsart, Christiane, Kiprianova, Irina, Schlehofer, Joerg R, Raykov, Zahari

“…Abstract The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in…”
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Double-faceted mechanism of parvoviral oncosuppression by Geletneky, Karsten, Nüesch, Jürg PF, Angelova, Assia, Kiprianova, Irina, Rommelaere, Jean

“…•H-1PV propagation in human glioma cells can be improved through forced selection.•Arming of H-1PV vectors with immunostimulants enhances tumor vaccine…”
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Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner12 by Kiprianova, Irina, Remy, Janina, Milosch, Nelli, Mohrenz, Isabelle V., Seifert, Volker, Aigner, Achim, Kögel, Donat

“…The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is overactivated in malignant glioma and plays a key role in…”
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Regression of Glioma in Rat Models by Intranasal Application of Parvovirus H-1 by KIPRIANOVA, Irina, THOMAS, Nadja, AYACHE, Ali, FISCHER, Manuel, LEUCHS, Barbara, KLEIN, Michele, ROMMELAERE, Jean, SCHLEHOFER, Jörg R

“…In previous studies, we have shown that the apathogenic rat parvovirus H-1 (H-1PV) is capable to induce regression of advanced symptomatic rat and human…”
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Regression of advanced rat and human gliomas by local or systemic treatment with oncolytic parvovirus H-1 in rat models by Geletneky, Karsten, Kiprianova, Irina, Ayache, Ali, Koch, Regina, Herrero y Calle, Marta, Deleu, Laurent, Sommer, Clemens, Thomas, Nadja, Rommelaere, Jean, Schlehofer, Jörg R.

“…Oncolytic virotherapy is a potential treatment modality under investigation for various malignancies including malignant brain tumors. Unlike some other…”
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Oncolytic Rat Parvovirus H-1PV, a Candidate for the Treatment of Human Lymphoma: In Vitro and In Vivo Studies by Angelova, Assia L, Aprahamian, Marc, Balboni, Ginette, Delecluse, Henri-Jacques, Feederle, Regina, Kiprianova, Irina, Grekova, Svitlana P, Galabov, Angel S, Witzens-Harig, Mathias, Ho, Anthony D, Rommelaere, Jean, Raykov, Zahari

“…The incidence of lymphomas developing in both immunocompetent and immunosuppressed patients continues to steadily increase worldwide. Current chemotherapy and…”
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Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2 by Kiprianova, Irina, Schindowski, Katharina, von Bohlen und Halbach, Oliver, Krause, Sonja, Dono, Rosanna, Schwaninger, Markus, Unsicker, Klaus

“…FGF-2, a potent multifunctional and neurotrophic growth factor, is widely expressed in the brain and upregulated in cerebral ischemia. Previous studies have…”
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Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat by Kiprianova, Irina, Freiman, Thomas M., Desiderato, Stephanie, Schwab, Stefan, Galmbacher, Roland, Gillardon, Frank, Spranger, Matthias

“…The expression of brain‐derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B are both increased after global ischemia. Therefore, a protective…”
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Reoxygenation increases the release of reactive oxygen intermediates in murine microglia by Spranger, M, Kiprianova, I, Krempien, S, Schwab, S

“…Respiratory burst activity of murine microglial cells was investigated in vitro under normoxic and hypoxic conditions with a chemoluminometric assay. Hypoxia…”
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Suppression of the oxidative burst in murine microglia by nitric oxide by Kiprianova, Irina, Schwab, Stefan, Fandrey, Joachim, Spranger, Matthias

“…The effect of nitric oxide (NO) on the oxidative burst was analyzed in purified murine microglial cells in vitro. The generation of reactive oxygen derivatives…”
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