Search Results - "KIPPS, T. J"

International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia by RAWSTRON, A. C, VILLAMOR, N, EVAN, P. A. S, NATKUNAM, Y, COUTRE, S. E, AVERY, E. D, RASSENTI, L. Z, KIPPS, T. J, CALIGARIS-CAPPIO, F, KNEBA, M, BYRD, J. C, HALLEK, M. J, RITGEN, M, MONTSERRAT, E, HILLMEN, P, BÖTTCHER, S, GHIA, P, ZEHNDER, J. L, LOZANSKI, G, COLOMER, D, MORENO, C, GEUNA, M

“…The eradication of minimal residual disease (MRD) in chronic lymphocytic leukaemia (CLL) predicts for improved outcome. However, the wide variety of MRD…”
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Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia by Castro, J E, Sandoval-Sus, J D, Bole, J, Rassenti, L, Kipps, T J

“…We examined the clinical response of fludarabine-refractory CLL patients treated with high-dose methylprednisolone (HDMP) and rituximab. Fourteen patients were…”
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EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia by Young, E, Noerenberg, D, Mansouri, L, Ljungström, V, Frick, M, Sutton, L-A, Blakemore, S J, Galan-Sousa, J, Plevova, K, Baliakas, P, Rossi, D, Clifford, R, Roos-Weil, D, Navrkalova, V, Dörken, B, Schmitt, C A, Smedby, K E, Juliusson, G, Giacopelli, B, Blachly, J S, Belessi, C, Panagiotidis, P, Chiorazzi, N, Davi, F, Langerak, A W, Oscier, D, Schuh, A, Gaidano, G, Ghia, P, Xu, W, Fan, L, Bernard, O A, Nguyen-Khac, F, Rassenti, L, Li, J, Kipps, T J, Stamatopoulos, K, Pospisilova, S, Zenz, T, Oakes, C C, Strefford, J C, Rosenquist, R, Damm, F

“…Recurrent mutations within EGR2 were recently reported in advanced-stage chronic lymphocytic leukemia (CLL) patients and associated with a worse outcome. To…”
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A phase I study of immune gene therapy for patients with CLL using a membrane-stable, humanized CD154 by Wierda, W G, Castro, J E, Aguillon, R, Sampath, D, Jalayer, A, McMannis, J, Prussak, C E, Keating, M, Kipps, T J

“…Ligation of CD40 on chronic lymphocytic leukemia (CLL) cells induces phenotypic and biochemical changes that facilitate CLL cell–T cell interactions and…”
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Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia by MOTTA, M, RASSENTI, L, SHELVIN, B. J, LERNER, S, KIPPS, T. J, KEATING, M. J, WIERDA, W. G

“…Patients with chronic lymphocytic leukemia (CLL) have defects in both cellular and humoral immunity. Since CD152 (CTLA-4) plays a critical role in…”
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Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL) by O'Hayre, M, Niederst, M, Fecteau, J F, Nguyen, V M, Kipps, T J, Messmer, D, Newton, A C, Handel, T M

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Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell–derived factor-1 by Burger, Jan A., Tsukada, Nobuhiro, Burger, Meike, Zvaifler, Nathan J., Dell'Aquila, Marie, Kipps, Thomas J.

“…A subset of blood cells from patients with B-cell chronic lymphocytic leukemia (CLL) spontaneously differentiates in vitro into large, round, or…”
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Extended follow-up and impact of high-risk prognostic factors from the phase 3 RESONATE study in patients with previously treated CLL/SLL by Brown, J R, Hillmen, P, O’Brien, S, Barrientos, J C, Reddy, N M, Coutre, S E, Tam, C S, Mulligan, S P, Jaeger, U, Barr, P M, Furman, R R, Kipps, T J, Cymbalista, F, Thornton, P, Caligaris-Cappio, F, Delgado, J, Montillo, M, DeVos, S, Moreno, C, Pagel, J M, Munir, T, Burger, J A, Chung, D, Lin, J, Gau, L, Chang, B, Cole, G, Hsu, E, James, D F, Byrd, J C

“…In the phase 3 RESONATE study, ibrutinib demonstrated superior progression-free survival (PFS), overall survival (OS) and overall response rate (ORR) compared…”
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Trisomy 12 CLLs progress through NOTCH1 mutations by Balatti, V, Lerner, S, Rizzotto, L, Rassenti, L Z, Bottoni, A, Palamarchuk, A, Cascione, L, Alder, H, Keating, M J, Kipps, T J, Pekarsky, Y, Croce, C M

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Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors by Fais, F, Ghiotto, F, Hashimoto, S, Sellars, B, Valetto, A, Allen, S L, Schulman, P, Vinciguerra, V P, Rai, K, Rassenti, L Z, Kipps, T J, Dighiero, G, Schroeder, Jr, H W, Ferrarini, M, Chiorazzi, N

“…To better understand the stage(s) of differentiation reached by B-type chronic lymphocytic leukemia (B-CLL) cells and to gain insight into the potential role…”
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Elevation of soluble CD307 (IRTA2 FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma by ISE, T, NAGATA, S, KYLE, R. A, JELINEK, D. F, PASTAN, I, KREITMAN, R. J, WILSON, W. H, WAYNE, A. S, STETLER-STEVENSON, M, BISHOP, M. R, SCHEINBERG, D. A, RASSENTI, L, KIPPS, T. J

“…CD307 is a differentiation antigen expressed in B-lineage cells. One soluble and two membrane-bound forms have been predicted and an enzyme-linked…”
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Relative seroprevalence of human herpes viruses in patients with chronic lymphocytic leukaemia by Steininger, C., Rassenti, L. Z., Vanura, K., Eigenberger, K., Jäger, U., Kipps, T. J., Mannhalter, C., Stilgenbauer, S., Popow-Kraupp, T.

“…Background  Herpes virus infections may have a significant role in chronic lymphocytic leukaemia (CLL) due to their ability to modulate the host’s immune…”
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Laser microdissection for the assessment of the clonal relationship between chronic lymphocytic leukemia small lymphocytic lymphoma and proliferating B cells within lymph node pseudofollicles by Vandewoestyne, M L, Pede, V C, Lambein, K Y, Dhaenens, M F, Offner, F C, Praet, M M, Philippé, J J, Kipps, T J, Deforce, D L

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Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib by Yu, J, Chen, L, Cui, B, Wu, Christina, Choi, M Y, Chen, Y, Zhang, L, Rassenti, L Z, Widhopf II, G F, Kipps, T J

“…Signaling via the B cell receptor (BCR) plays an important role in the pathogenesis and progression of chronic lymphocytic leukemia (CLL). This is underscored…”
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A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study by Rawstron, A C, Fazi, C, Agathangelidis, A, Villamor, N, Letestu, R, Nomdedeu, J, Palacio, C, Stehlikova, O, Kreuzer, K-A, Liptrot, S, O'Brien, D, de Tute, R M, Marinov, I, Hauwel, M, Spacek, M, Dobber, J, Kater, A P, Gambell, P, Soosapilla, A, Lozanski, G, Brachtl, G, Lin, K, Boysen, J, Hanson, C, Jorgensen, J L, Stetler-Stevenson, M, Yuan, C, Broome, H E, Rassenti, L, Craig, F, Delgado, J, Moreno, C, Bosch, F, Egle, A, Doubek, M, Pospisilova, S, Mulligan, S, Westerman, D, Sanders, C M, Emerson, R, Robins, H S, Kirsch, I, Shanafelt, T, Pettitt, A, Kipps, T J, Wierda, W G, Cymbalista, F, Hallek, M, Hillmen, P, Montserrat, E, Ghia, P

“…In chronic lymphocytic leukemia (CLL) the level of minimal residual disease (MRD) after therapy is an independent predictor of outcome. Given the increasing…”
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Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells by Hasan, M K, Yu, J, Chen, L, Cui, Bing, Widhopf II, G F, Rassenti, L, Shen, Z, Briggs, S P, Kipps, T J

“…ROR1 (receptor tyrosine kinase-like orphan receptor 1) is a conserved, oncoembryonic surface antigen expressed in chronic lymphocytic leukemia (CLL). We found…”
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Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal by RANHEIM, E. A, KIPPS, T. J

“…Cognate interactions between antigen-presenting B and T cells play crucial roles in immunologic responses. T cells that have been activated via the…”
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Intratumoral delivery of CD154 homolog (Ad-ISF35) induces tumor regression: analysis of vector biodistribution, persistence and gene expression by Melo-Cardenas, J, Urquiza, M, Kipps, T J, Castro, J E

“…Ad-ISF35 is an adenovirus (Ad) vector that encodes a mouse–human chimeric CD154. Ad-ISF35 induces activation of chronic lymphocytic leukemia (CLL) cells…”
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Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells by Yu, J, Chen, L, Chen, Y, Hasan, M K, Ghia, E M, Zhang, L, Wu, R, Rassenti, L Z, Widhopf, G F, Shen, Z, Briggs, S P, Kipps, T J

“…Wnt5a can activate Rho GTPases in chronic lymphocytic leukemia (CLL) cells by inducing the recruitment of ARHGEF2 to ROR1. Mass spectrometry on immune…”
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Soluble CD154 in rheumatoid arthritis: elevated plasma levels in cases with vasculitis by TAMURA, Naoto, KOBAYASHI, Shigeto, KATO, Kazunori, BANDO, Hideaki, HARUTA, Kazuhiko, OYANAGI, Mutsuko, KURIYAMA, Makiyo, KIPPS, Thomas J, HASHIMOTO, Hiroshi

“…OBJECTIVE: To determine the levels of soluble CD154 (sCD154) in the plasma of patients with rheumatoid arthritis (RA) and rheumatoid vasculitis (RV). and to…”
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