Search Results - "KINZEL, Olaf D"

3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors by Donghi, Monica, Kinzel, Olaf D, Summa, Vincenzo

“…A new class of inhibitors of HIV-1 integrase has been optimized to provide selective and highly efficient strand transfer inhibition…”
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3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates-A new class of HIV-1 integrase inhibitors by DONGHI, Monica, KINZEL, Olaf D, SUMMA, Vincenzo

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Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant by Muraglia, Ester, Kinzel, Olaf D., Laufer, Ralph, Miller, Michael D., Moyer, Gregory, Munshi, Vandna, Orvieto, Federica, Palumbi, Maria Cecilia, Pescatore, Giovanna, Rowley, Michael, Williams, Peter D., Summa, Vincenzo

“…SAR study on tetrazole thioacetanilides as NNRTIs led to potent compounds, with nanomolar activity on both WT HIV and on the clinically relevant K103N mutant,…”
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3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates—fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors by Kinzel, Olaf D., Ball, Richard G., Donghi, Monica, Maguire, Courtney K., Muraglia, Ester, Pesci, Silvia, Rowley, Michael, Summa, Vincenzo

“…An efficient and reliable synthesis of the heterocyclic scaffold methyl- 3-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate is described. The scope of…”
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3-Hydroxy-4-oxo-4 H-pyrido[1,2- a]pyrimidine-2-carboxylates—A new class of HIV-1 integrase inhibitors by Donghi, Monica, Kinzel, Olaf D., Summa, Vincenzo

“…The synthesis and SAR of a new class of HIV-1 integrase inhibitors is reported. A new class of inhibitors of HIV-1 integrase has been optimized to provide…”
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A novel base-mediated intramolecular hydroamination to build fused heteroaryl pyrazinones by Llauger, Laura, Bergami, Costanza, Kinzel, Olaf D., Lillini, Samuele, Pescatore, Giovanna, Torrisi, Caterina, Jones, Philip

“…Functionalized fused heteroaryl pyrazinones were built up through a novel DBU-catalyzed intramolecular hydroamination reaction of aryl(prop-2-yn-1-yl)-1…”
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The synthesis of tetrahydropyridopyrimidones as a new scaffold for HIV-1 integrase inhibitors by Kinzel, Olaf D., Monteagudo, Edith, Muraglia, Ester, Orvieto, Federica, Pescatore, Giovanna, Ferreira, Maria del Rosario Rico, Rowley, Michael, Summa, Vincenzo

“…An efficient synthesis of methyl 9-amino-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-4 H-pyrido[1,2- a]pyrimidine-2-carboxylate as a late stage intermediate for a new…”
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3-Hydroxy-4-oxo-4 H-pyrido[1,2- a]pyrimidine-2-carboxylates—fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors by Kinzel, Olaf D., Ball, Richard G., Donghi, Monica, Maguire, Courtney K., Muraglia, Ester, Pesci, Silvia, Rowley, Michael, Summa, Vincenzo

“…An efficient and reliable synthesis of the heterocyclic scaffold methyl-3-hydroxy-4-oxo-4 H-pyrido[1,2- a]pyrimidine-2-carboxylate is described. The scope of…”
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