Search Results - "KINGSMAN, ALAN J."

Efficient production of germline transgenic chickens using lentiviral vectors by McGrew, Michael J, Sherman, Adrian, Ellard, Fiona M, Lillico, Simon G, Gilhooley, Hazel J, Kingsman, Alan J, Mitrophanous, Kyriacos A, Sang, Helen

“…An effective method for genetic modification of chickens has yet to be developed. An efficient technology, enabling production of transgenic birds at high…”
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Multicistronic Lentiviral Vector-Mediated Striatal Gene Transfer of Aromatic L-Amino Acid Decarboxylase, Tyrosine Hydroxylase, and GTP Cyclohydrolase I Induces Sustained Transgene Expression, Dopamine Production, and Functional Improvement in a Rat Model of Parkinson's Disease by Azzouz, Mimoun, Martin-Rendon, Enca, Barber, Robert D, Mitrophanous, Kyriacos A, Carter, Emma E, Rohll, Jonathan B, Kingsman, Susan M, Kingsman, Alan J, Mazarakis, Nicholas D

“…Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in the substantia nigra. This loss leads…”
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Retinoic acid receptor β2 promotes functional regeneration of sensory axons in the spinal cord by Wong, Liang-Fong, Mazarakis, Nicholas D, Yip, Ping K, Battaglia, Anna, Grist, John, Corcoran, Jonathan, Maden, Malcolm, Azzouz, Mimoun, Kingsman, Susan M, Kingsman, Alan J, McMahon, Stephen B

“…The embryonic CNS readily undergoes regeneration, unlike the adult CNS, which has limited axonal repair after injury. Here we tested the hypothesis that…”
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Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery by MAZARAKIS, Nicholas D, AZZOUZ, Mimoun, KINGSMAN, Alan J, O'MALLEY, Karen, MITROPHANOUS, Kyriacos A, ROHLL, Jonathan B, ELLARD, Fiona M, WILKES, Fraser J, OLSEN, Anna L, CARTER, Emma E, BARBER, Robert D, BABAN, Dilair F, KINGSMAN, Susan M

“…In this report it is demonstrated for the first time that rabies-G envelope of the rabies virus is sufficient to confer retrograde axonal transport to a…”
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Optimizing Transgene Configuration and Protein Fusions to Maximize Dopamine Production for the Gene Therapy of Parkinson's Disease by Stewart, Hannah J, Ralph, G Scott, Fong-Wong, Liang, Strickland, Iain, McCloskey, Laura, Barnes, Lucy, Blount, Ian, Wells, Owen, Truran, Christelle J M, Kingsman, Alan J, Palfi, Stéphane, Mitrophanous, Kyriacos A

“…Pharmacological dopamine replacement therapies provide the most well-established treatments for Parkinson's disease (PD). However, these long-term treatments…”
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Effects of stoichiometry of retroviral components on virus production by Yap, Melvyn W, Kingsman, Susan M, Kingsman, Alan J

“…Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK 1 Oxford BioMedica (UK) Ltd, The Medawar Centre, The Oxford Science…”
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A transient three-plasmid expression system for the production of high titer retroviral vectors by Soneoka, Yuko, Cannon, Paula M., Ramsdale, Emma E., Griffiths, Joanne C., Romano, Gaetano, Kingsman, Susan M., Kingsman, Alan J.

“…We have constructed a series of MLV-based retroviral vectors and packaging components expressed from the CMV promoter and carried on plasmids containing SV40…”
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Minimal Requirement for a Lentivirus Vector Based on Human Immunodeficiency Virus Type 1 by Kim, V N, Mitrophanous, K, Kingsman, S M, Kingsman, A J

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Blocking of Tat-dependent HIV-1 RNA modification by an inhibitor of RNA polymerase II processivity by Braddock, Martin, Thorburn, Andrew M, Kingsman, Alan J, Kingsman, Susan M

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Split-Intron Retroviral Vectors: Enhanced Expression with Improved Safety by Ismail, S I, Kingsman, S M, Kingsman, A J, Uden, M

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Characterization of the equine infectious anaemia virus S2 protein by Yoon, Soonsang, Kingsman, Susan M, Kingsman, Alan J, Wilson, Stuart A, Mitrophanous, Kyriacos A

“…Retrovirus Molecular Biology Group, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK 1 Oxford BioMedica (UK) Ltd, Oxford…”
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Use of Intron-Disrupted Polyadenylation Sites To Enhance Expression and Safety of Retroviral Vectors by Ismail, S I, Rohll, J B, Kingsman, S M, Kingsman, A J, Uden, M

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The expression of hybrid HIV:Ty virus-like particles in yeast by Adams, Sally E, Dawson, Keith M, Gull, Keith, Kingsman, Susan M, Kingsman, Alan J

“…The yeast retrotransposon, Ty, encodes a set of proteins that are assembled into virus-like particles, Ty-VLPs (refs 1, 2). These proteins include Ty-VLP…”
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Reverse transcriptase activity and Ty RNA are associated with virus-like particles in yeast by Mellor, Jane, Malim, Michael H, Gull, Keith, Tuite, Mick F, McCready, Shirley, Dibbayawan, Teresa, Kingsman, Susan M, Kingsman, Alan J

“…The Ty element of yeast represents a class of eukaryotic transposons that show remarkable structural similarity to retroviral proviruses. Recently, these…”
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Structural determinants within the subunit protein of Ty1 virus-like particles by Martin-Rendon, E, Marfany, G, Wilson, S, Ferguson, D J, Kingsman, S M, Kingsman, A J

“…The Ty virus-like particles (VLPs) are functionally analogous to retroviral particles. They package the enzymes and the RNA necessary for retrotransposition,…”
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The functions and relationships of Ty-VLP proteins in yeast reflect those of mammalian retroviral proteins by Adams, S E, Mellor, J, Gull, K, Sim, R B, Tuite, M F, Kingsman, S M, Kingsman, A J

“…We have identified the major structural core proteins of Ty virus-like particles (Ty-VLPs) and shown that they are generated by proteolytic cleavage of the…”
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A Rev-independent human immunodeficiency virus type 1 (HIV-1)-based vector that exploits a codon-optimized HIV-1 gag-pol gene by Kotsopoulou, E, Kim, V N, Kingsman, A J, Kingsman, S M, Mitrophanous, K A

“…The human immunodeficiency virus (HIV) genome is AU rich, and this imparts a codon bias that is quite different from the one used by human genes. The codon…”
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Replication in Saccharomyces cerevisiae of plasmid pBR313 carrying DNA from the yeast trpl region by Kingsman, A J, Clarke, L, Mortimer, R K, Carbon, J

“…Plasmid pBR313 carrying a 1.4 kb EcoRI fragment from the yeast TRP1 region (designated pLC544) is capable of transforming yeast trp1 mutants to Trp+ at high…”
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Functional dissection of the Moloney murine leukemia virus envelope protein gp70 by Bae, Y, Kingsman, S M, Kingsman, A J

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Retinoic acid receptor [beta]2 promotes functional regeneration of sensory axons in the spinal cord by Liang-Fong, Wong, Yip, Ping K, Battaglia, Anna, Grist, John, Corcoran, Jonathan, Maden, Malcolm, Azzouz, Mimoun, Kingsman, Susan M, Kingsman, Alan J, Mazarakis, Nicholas D, McMahon, Stephen B

“…The embryonic CNS readily undergoes regeneration, unlike the adult CNS, which has limited axonal repair after injury. Here we tested the hypothesis that…”
Get full text