Search Results - "KING, David J"

APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016 by O'Toole, Áine, Neher, Richard A, Ndodo, Nnaemeka, Borges, Vitor, Gannon, Ben, Gomes, João Paulo, Groves, Natalie, King, David J, Maloney, Daniel, Lemey, Philippe, Lewandowski, Kuiama, Loman, Nicholas, Myers, Richard, Omah, Ifeanyi F, Suchard, Marc A, Worobey, Michael, Chand, Meera, Ihekweazu, Chikwe, Ulaeto, David, Adetifa, Ifedayo, Rambaut, Andrew

“…Historically, mpox has been characterized as an endemic zoonotic disease that transmits through contact with the reservoir rodent host in West and Central…”
Get full text

Establishing an In Vitro System to Assess How Specific Antibodies Drive the Evolution of Foot-and-Mouth Disease Virus by King, David J, Freimanis, Graham, Neil, Chris, Shaw, Andrew, Tuthill, Tobias J, Laing, Emma, King, Donald P, Lasecka-Dykes, Lidia

“…Viruses can evolve to respond to immune pressures conferred by specific antibodies generated after vaccination and/or infection. In this study, an in vitro…”
Get full text

Correction: King et al. Establishing an In Vitro System to Assess How Specific Antibodies Drive the Evolution of Foot-and-Mouth Disease Virus. Viruses 2022, 14 , 1820 by King, David J, Freimanis, Graham, Neil, Chris, Shaw, Andrew, Tuthill, Tobias J, Laing, Emma, King, Donald P, Lasecka-Dykes, Lidia

“…In the original publication [...]…”
Get full text

A Systematic Evaluation of High-Throughput Sequencing Approaches to Identify Low-Frequency Single Nucleotide Variants in Viral Populations by King, David J, Freimanis, Graham, Lasecka-Dykes, Lidia, Asfor, Amin, Ribeca, Paolo, Waters, Ryan, King, Donald P, Laing, Emma

“…High-throughput sequencing such as those provided by Illumina are an efficient way to understand sequence variation within viral populations. However,…”
Get full text

Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses by Adams, Ryan A., Fernandes-Cerqueira, Cátia, Notarnicola, Antonella, Mertsching, Elisabeth, Xu, Zhiwen, Lo, Wing-Sze, Ogilvie, Kathleen, Chiang, Kyle P., Ampudia, Jeanette, Rosengren, Sanna, Cubitt, Andrea, King, David J., Mendlein, John D., Yang, Xiang-Lei, Nangle, Leslie A., Lundberg, Ingrid E., Jakobsson, Per-Johan, Schimmel, Paul

“…His-tRNA synthetase (HARS) is targeted by autoantibodies in chronic and acute inflammatory anti-Jo-1-positive antisynthetase syndrome. The extensive activation…”
Get full text

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies by Bowers, Peter M, Horlick, Robert A, Neben, Tamlyn Y, Toobian, Rachelle M, Tomlinson, Geoffrey L, Dalton, Jennifer L, Jones, Heather A, Chen, Andy, Altobell, Laurence III, Zhang, Xue, Macomber, John L, Krapf, Irina P, Wu, Betty F, McConnell, Audrey, Chau, Betty, Holland, Trevin, Berkebile, Ashley D, Neben, Steven S, Boyle, William J, King, David J

“…A novel approach has been developed for the isolation and maturation of human antibodies that replicates key features of the adaptive immune system by coupling…”
Get full text

Mammalian cell display for the discovery and optimization of antibody therapeutics by Bowers, Peter M., Horlick, Robert A., Kehry, Marilyn R., Neben, Tamlyn Y., Tomlinson, Geoffery L., Altobell, Larry, Zhang, Xue, Macomber, John L., Krapf, Irina P., Wu, Betty F., McConnell, Audrey D., Chau, Betty, Berkebile, Ashley D., Hare, Eric, Verdino, Petra, King, David J.

“…Recent advances are described for the isolation and affinity maturation of antibodies that couple in vitro somatic hypermutation (SHM) with mammalian cell…”
Get full text

Isolation of monoclonal antibodies from anti-synthetase syndrome patients and affinity maturation by recombination of independent somatic variants by Burman, Luke, Chong, Yeeting E, Duncan, Sherie, Klaus, Anders, Rauch, Kaitlyn, Hamel, Kristina, Hervé, Karine, Pfaffen, Stephanie, Collins, David W, Heyries, Kevin, Nangle, Leslie, Hansen, Carl, King, David J

“…The autoimmune disease known as Jo-1 positive anti-synthetase syndrome (ASS) is characterized by circulating antibody titers to histidyl-tRNA synthetase…”
Get full text

Simultaneous Surface Display and Secretion of Proteins from Mammalian Cells Facilitate Efficient in Vitro Selection and Maturation of Antibodies by Horlick, Robert A., Macomber, John L., Bowers, Peter M., Neben, Tamlyn Y., Tomlinson, Geoffery L., Krapf, Irina P., Dalton, Jennifer L., Verdino, Petra, King, David J.

“…A mammalian expression system has been developed that permits simultaneous cell surface display and secretion of the same protein through alternate splicing of…”
Get full text

High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutation by McConnell, Audrey D, Do, Minjee, Neben, Tamlyn Y, Spasojevic, Vladimir, MacLaren, Josh, Chen, Andy P, Altobell, 3rd, Laurence, Macomber, John L, Berkebile, Ashley D, Horlick, Robert A, Bowers, Peter M, King, David J

“…A method has been developed for the rapid generation of high-affinity humanized antibodies from immunized animals without the need to make conventional…”
Get full text

Mammalian cell display and somatic hypermutation in vitro for human antibody discovery by King, David J, Bowers, Peter M, Kehry, Marilyn R, Horlick, Robert A

“…Human therapeutic antibody discovery has utilized a variety of systems, from in vivo immunization of human immunoglobulin-expressing mice, to in vitro display…”
Get more information

In vitro and In vivo Characterization of MDX-1401 for Therapy of Malignant Lymphoma by CARDARELLI, Pina M, MOLDOVAN-LOOMIS, Maria-Cristina, ASSAD, Albert, WITTE, Alison, GRAZIANO, Robert F, KING, David J, PRESTON, Ben, BLACK, Amelia, PASSMORE, David, CHEN, Tseng-Hui, CHEN, Sharline, JIE LIU, KUHNE, Michelle R, SRINIVASAN, Mohan

“…Purpose: This study was undertaken to evaluate the effects of MDX-1401, a nonfucosylated fully human monoclonal antibody that binds to human CD30, and to…”
Get full text

A review of the importance of the Caribbean region in Oligo-Miocene low latitude planktonic foraminiferal biostratigraphy and the implications for modern biogeochronological schemes by King, David J., Wade, Bridget S., Liska, Robert D., Miller, C. Giles

“…Planktonic foraminifera are widely used in marine biostratigraphy thanks to their small size, limited stratigraphic range and abundance in oceanic sediments…”
Get full text

Human Prions and Plasma Lipoproteins by Safar, Jiri G., Wille, Holger, Geschwind, Michael D., Deering, Camille, Latawiec, Diane, Serban, Ana, King, David J., Legname, Giuseppe, Weisgraber, Karl H., Mahley, Robert W., Miller, Bruce L., DeArmond, Stephen J., Prusiner, Stanley B.

“…Prions are composed solely of an alternatively folded isoform of the prion protein (PrP), designated$PrP^{Sc}$. The polyoxometalate phosphotungstic acid has…”
Get full text

Symptomatic sinus bradycardia following laparoscopic sleeve gastrectomy: A case series by King, David J, Johnson-Mann, Crystal, Goel, Ramil, Xiang, Kun

Get full text

Systematic Review of Literature Citing the ISCHEMIA Trial by King, David J., Eskander, Christian, Ricci, Jacob, Gittess, David, Patel, Rushi, Bourne, Mitchell, Budweg, Jeffery, Winchester, David E.

“…Purpose of Review Optimal therapy for patients with chronic coronary artery disease (CCD) has long been a topic under investigation and a subject of debate…”
Get full text

Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects by Leonard, Brian E., McCartan, Denise, White, John, King, David J.

Get full text

Drug treatment of the negative symptoms of schizophrenia by King, David J

“…The traditional antipsychotics are generally poorly effective or ineffective against the negative symptoms of schizophrenia and are also associated with…”
Get full text

A universal protocol to generate consensus level genome sequences for foot-and-mouth disease virus and other positive-sense polyadenylated RNA viruses using the Illumina MiSeq by Logan, Grace, Freimanis, Graham L, King, David J, Valdazo-González, Begoña, Bachanek-Bankowska, Katarzyna, Sanderson, Nicholas D, Knowles, Nick J, King, Donald P, Cottam, Eleanor M

“…Next-Generation Sequencing (NGS) is revolutionizing molecular epidemiology by providing new approaches to undertake whole genome sequencing (WGS) in diagnostic…”
Get full text

Efficacy of a high-potency multivalent foot-and-mouth disease virus vaccine in cattle against heterologous challenge with a field virus from the emerging A/ASIA/G-VII lineage by Waters, Ryan, Ludi, Anna B., Fowler, Veronica L., Wilsden, Ginette, Browning, Clare, Gubbins, Simon, Statham, Bob, Bin-Tarif, Abdelghani, Mioulet, Valerie, King, David J., Colenutt, Claire, Brown, Emma, Hudelet, Pascal, King, Donald P.

“…•FMDV A/ASIA/G-VII lineage has recently spread beyond the Indian sub-continent.•Study evaluated the performance of a high potency polyvalent vaccine in…”
Get full text