Search Results - "KINDON, Nicholas D."

A novel and selective fluorescent ligand for the study of adenosine A2B receptors by Patera, Foteini, Mistry, Sarah J., Kindon, Nicholas D., Comeo, Eleonora, Goulding, Joelle, Kellam, Barrie, Kilpatrick, Laura E., Franks, Hester, Hill, Stephen J.

“…Fluorescent ligands have proved to be powerful tools in the study of G protein‐coupled receptors in living cells. Here we have characterized a new fluorescent…”
Get full text

Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A2A Receptor by Comeo, Eleonora, Kindon, Nicholas D, Soave, Mark, Stoddart, Leigh A, Kilpatrick, Laura E, Scammells, Peter J, Hill, Stephen J, Kellam, Barrie

“…Among class A G protein-coupled receptors (GPCR), the human adenosine A2A receptor (hA2AAR) remains an attractive drug target. However, translation of A2AAR…”
Get full text

Enamines from Terminal Epoxides and Hindered Lithium Amides by Hodgson, David M, Bray, Christopher D, Kindon, Nicholas D

“…A new reactivity mode of lithium amides with epoxides leads to hindered enamines. The reaction of some of these enamines with unactivated primary and secondary…”
Get full text

Ligand-Directed Labeling of the Adenosine A 1 Receptor in Living Cells by Comeo, Eleonora, Goulding, Joëlle, Lin, Chia-Yang, Groenen, Marleen, Woolard, Jeanette, Kindon, Nicholas D, Harwood, Clare R, Platt, Simon, Briddon, Stephen J, Kilpatrick, Laura E, Scammells, Peter J, Hill, Stephen J, Kellam, Barrie

“…The study of protein function and dynamics in their native cellular environment is essential for progressing fundamental science. To overcome the requirement…”
Get full text

Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells by Comeo, Eleonora, Goulding, Joëlle, Lin, Chia-Yang, Groenen, Marleen, Woolard, Jeanette, Kindon, Nicholas D., Harwood, Clare R., Platt, Simon, Briddon, Stephen J., Kilpatrick, Laura E., Scammells, Peter J., Hill, Stephen J., Kellam, Barrie

“…The study of protein function and dynamics in their native cellular environment is essential for progressing fundamental science. To overcome the requirement…”
Get full text

Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor by Dekkers, Sebastian, Caspar, Birgit, Goulding, Joëlle, Kindon, Nicholas D., Kilpatrick, Laura E., Stoddart, Leigh A., Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J., Stocks, Michael J.

“…The C–X–C chemokine receptor type 4, or CXCR4, is a chemokine receptor found to promote cancer progression and metastasis of various cancer cell types. To…”
Get full text

Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y 2 Receptor Based on AR-C118925 by Conroy, Sean, Kindon, Nicholas D, Glenn, Jacqueline, Stoddart, Leigh A, Lewis, Richard J, Hill, Stephen J, Kellam, Barrie, Stocks, Michael J

“…The human P2Y receptor ( hP2Y R) is a G-protein-coupled receptor that shows promise as a therapeutic target for many important conditions, including for…”
Get full text

Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A1 Receptor in Living Cells by Comeo, Eleonora, Trinh, Phuc, Nguyen, Anh T, Nowell, Cameron J, Kindon, Nicholas D, Soave, Mark, Stoddart, Leigh A, White, Jonathan M, Hill, Stephen J, Kellam, Barrie, Halls, Michelle L, May, Lauren T, Scammells, Peter J

“…The adenosine A1 receptor (A1AR) is a G-protein-coupled receptor (GPCR) that provides important therapeutic opportunities for a number of conditions including…”
Get full text

Subtype-Selective Fluorescent Ligands as Pharmacological Research Tools for the Human Adenosine A 2A Receptor by Comeo, Eleonora, Kindon, Nicholas D, Soave, Mark, Stoddart, Leigh A, Kilpatrick, Laura E, Scammells, Peter J, Hill, Stephen J, Kellam, Barrie

“…Among class A G protein-coupled receptors (GPCR), the human adenosine A receptor (hA AR) remains an attractive drug target. However, translation of A AR…”
Get full text

Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A 1 Receptor in Living Cells by Comeo, Eleonora, Trinh, Phuc, Nguyen, Anh T, Nowell, Cameron J, Kindon, Nicholas D, Soave, Mark, Stoddart, Leigh A, White, Jonathan M, Hill, Stephen J, Kellam, Barrie, Halls, Michelle L, May, Lauren T, Scammells, Peter J

“…The adenosine A receptor (A AR) is a G-protein-coupled receptor (GPCR) that provides important therapeutic opportunities for a number of conditions including…”
Get full text

A novel and selective fluorescent ligand for the study of adenosine A 2B receptors by Patera, Foteini, Mistry, Sarah J, Kindon, Nicholas D, Comeo, Eleonora, Goulding, Joelle, Kellam, Barrie, Kilpatrick, Laura E, Franks, Hester, Hill, Stephen J

“…Fluorescent ligands have proved to be powerful tools in the study of G protein-coupled receptors in living cells. Here we have characterized a new fluorescent…”
Get full text

Correction to Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925 by Conroy, Sean, Kindon, Nicholas D, Glenn, Jacqueline, Stoddart, Leigh A, Lewis, Richard J, Hill, Stephen J, Kellam, Barrie, Stocks, Michael J

Get full text

Correction to Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y 2 Receptor Based on AR-C118925 by Conroy, Sean, Kindon, Nicholas D, Glenn, Jacqueline, Stoddart, Leigh A, Lewis, Richard J, Hill, Stephen J, Kellam, Barrie, Stocks, Michael J

Get full text

Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925 by Conroy, Sean, Kindon, Nicholas D, Glenn, Jacqueline, Stoddart, Leigh A, Lewis, Richard J, Hill, Stephen J, Kellam, Barrie, Stocks, Michael J

“…The human P2Y2 receptor (hP2Y2R) is a G-protein-coupled receptor that shows promise as a therapeutic target for many important conditions, including for…”
Get full text

Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells by Stoddart, Leigh A., Kindon, Nicholas D., Otun, Omolade, Harwood, Clare R., Patera, Foteini, Veprintsev, Dmitry B., Woolard, Jeanette, Briddon, Stephen J., Franks, Hester A., Hill, Stephen J., Kellam, Barrie

“…To study the localisation of G protein-coupled receptors (GPCR) in their native cellular environment requires their visualisation through fluorescent…”
Get full text

Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase‑4 (DPP-4), Antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol‑3 Kinase δ (PI3Kδ) Inhibitors by Schwehm, Carolin, Kellam, Barrie, Garces, Aimie E, Hill, Stephen J, Kindon, Nicholas D, Bradshaw, Tracey D, Li, Jin, Macdonald, Simon J. F, Rowedder, James E, Stoddart, Leigh A, Stocks, Michael J

“…A novel molecular scaffold has been synthesized, and its incorporation into new analogues of biologically active molecules across multiple target classes will…”
Get full text

Synthesis and C-Alkylation of Hindered Aldehyde Enamines by Hodgson, David M, Bray, Christopher D, Kindon, Nicholas D, Reynolds, Nigel J, Coote, Steven J, Um, Joann M, Houk, K. N

“…A new reactivity mode of hindered lithium amides with terminal epoxides is described whereby aldehyde enamines are produced via a previously unrecognized…”
Get full text

2-Ene-1,4-diols by Dimerization of Terminal Epoxides using Hindered Lithium Amides by Hodgson, David M, Bray, Christopher D, Kindon, Nicholas D

“…Reaction of hindered lithium amides with readily available (enantiopure) terminal epoxides gives 2-ene-1,4-diols via carbenoid dimerization of the…”
Get full text

Antagonists of the Platelet P 2T Receptor:  A Novel Approach to Antithrombotic Therapy by Ingall, Anthony H, Dixon, John, Bailey, Andrew, Coombs, Mandy E, Cox, David, McInally, Judith I, Hunt, Simon F, Kindon, Nicholas D, Teobald, Barry J, Willis, Paul A, Humphries, Robert G, Leff, Paul, Clegg, Jane A, Smith, James A, Tomlinson, Wendy

“…The platelet P 2T receptor plays a major role in platelet aggregation, and its antagonists are predicted to have significant therapeutic potential as…”
Get full text

Antagonists of the Platelet P2T Receptor:  A Novel Approach to Antithrombotic Therapy by INGALL, Anthony H., DIXON, John, BAILEY, Andrew, COOMBS, Mandy E., COX, David, MCINALLY, Judith I., HUNT, Simon F., KINDON, Nicholas D., TEOBALD, Barry J., WILLIS, Paul A., HUMPHRIES, Robert G., LEFF, Paul, CLEGG, Jane A., SMITH, James A., TOMLINSON, Wendy

“…The platelet P2T receptor plays a major role in platelet aggregation, and its antagonists are predicted to have significant therapeutic potential as…”
Get full text