Search Results - "KIM, Peter S"

A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery by Tang, Shaogeng, Kim, Peter S.

“…Immune checkpoint blockade of programmed death-1 (PD-1) by monoclonal antibody drugs has delivered breakthroughs in the treatment of cancer. Nonetheless,…”
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Efficient evolution of human antibodies from general protein language models by Hie, Brian L., Shanker, Varun R., Xu, Duo, Bruun, Theodora U. J., Weidenbacher, Payton A., Tang, Shaogeng, Wu, Wesley, Pak, John E., Kim, Peter S.

“…Natural evolution must explore a vast landscape of possible sequences for desirable yet rare mutations, suggesting that learning from natural evolutionary…”
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Protect, modify, deprotect (PMD): A strategy for creating vaccines to elicit antibodies targeting a specific epitope by Weidenbacher, Payton A., Kim, Peter S.

“…In creating vaccines against infectious agents, there is often a desire to direct an immune response toward a particular conformational epitope on an antigen…”
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Examining the efficacy of localised gemcitabine therapy for the treatment of pancreatic cancer using a hybrid agent-based model by Jenner, Adrianne L, Kelly, Wayne, Dallaston, Michael, Araujo, Robyn, Parfitt, Isobelle, Steinitz, Dominic, Pooladvand, Pantea, Kim, Peter S, Wade, Samantha J, Vine, Kara L

“…The prognosis for pancreatic ductal adenocarcinoma (PDAC) patients has not significantly improved in the past 3 decades, highlighting the need for more…”
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Enhancing HIV-1 Neutralization by Increasing the Local Concentration of Membrane-Proximal External Region-Directed Broadly Neutralizing Antibodies by Kim, Soohyun, Filsinger Interrante, Maria V, Kim, Peter S

“…Broadly neutralizing antibodies (bNAbs) against the membrane-proximal external region (MPER) of the gp41 component of the human immunodeficiency virus type 1…”
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Hydrogel‐Based Slow Release of a Receptor‐Binding Domain Subunit Vaccine Elicits Neutralizing Antibody Responses Against SARS‐CoV‐2 by Gale, Emily C., Powell, Abigail E., Roth, Gillie A., Meany, Emily L., Yan, Jerry, Ou, Ben S., Grosskopf, Abigail K., Adamska, Julia, Picece, Vittoria C. T. M., d'Aquino, Andrea I., Pulendran, Bali, Kim, Peter S., Appel, Eric A.

“…The development of effective vaccines that can be rapidly manufactured and distributed worldwide is necessary to mitigate the devastating health and economic…”
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The effects of inhibition and siRNA knockdown of collagen-binding integrins on human umbilical vein endothelial cell migration and tube formation by Hunter, Emma J., Hamaia, Samir W., Kim, Peter S.-K., Malcor, Jean-Daniel M., Farndale, Richard W.

“…Blood vessels in the body are lined with endothelial cells which have vital roles in numerous physiological and pathological processes. Collagens are major…”
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A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV‑2 in Mice by Powell, Abigail E, Zhang, Kaiming, Sanyal, Mrinmoy, Tang, Shaogeng, Weidenbacher, Payton A, Li, Shanshan, Pham, Tho D, Pak, John E, Chiu, Wah, Kim, Peter S

“…The development of a safe and effective SARS-CoV-2 vaccine is a public health priority. We designed subunit vaccine candidates using self-assembling ferritin…”
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Increased longevity evolves from grandmothering by Kim, Peter S., Coxworth, James E., Hawkes, Kristen

“…Postmenopausal longevity may have evolved in our lineage when ancestral grandmothers subsidized their daughters' fertility by provisioning grandchildren, but…”
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A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates by Weidenbacher, Payton A.-B., Sanyal, Mrinmoy, Friedland, Natalia, Tang, Shaogeng, Arunachalam, Prabhu S., Hu, Mengyun, Kumru, Ozan S., Morris, Mary Kate, Fontenot, Jane, Shirreff, Lisa, Do, Jonathan, Cheng, Ya-Chen, Vasudevan, Gayathri, Feinberg, Mark B., Villinger, Francois J., Hanson, Carl, Joshi, Sangeeta B., Volkin, David B., Pulendran, Bali, Kim, Peter S.

“…While the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting…”
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Legal medicine implications of a multidisciplinary approach to managing Traumatic Encephalopathy Syndrome in Australia by Kim, Peter S, Beran, Roy G

“…The medical profession has a fundamental obligation to accurately diagnose and effectively treat a range of diseases and conditions. In the case of Traumatic…”
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Human sperm TMEM95 binds eggs and facilitates membrane fusion by Tang, Shaogeng, Lu, Yonggang, Skinner, Will M., Sanyal, Mrinmoy, Lishko, Polina V., Ikawa, Masahito, Kim, Peter S.

“…Tmem95 encodes a sperm acrosomal membrane protein, whose knockout has a male-specific sterility phenotype in mice. Tmem95 knockout murine sperm can bind to,…”
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Grandmothering life histories and human pair bonding by Coxworth, James E., Kim, Peter S., McQueen, John S., Hawkes, Kristen

“…The evolution of distinctively human life history and social organization is generally attributed to paternal provisioning based on pair bonds. Here we develop…”
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Grandmothering drives the evolution of longevity in a probabilistic model by Kim, Peter S., McQueen, John S., Coxworth, James E., Hawkes, Kristen

“…We present a mathematical model based on the Grandmother Hypothesis to simulate how human post-menopausal longevity could have evolved as ancestral…”
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Identification of HIV gp41-specific antibodies that mediate killing of infected cells by Williams, Katherine L, Stumpf, Megan, Naiman, Nicole Elise, Ding, Shilei, Garrett, Meghan, Gobillot, Theodore, Vézina, Dani, Dusenbury, Katharine, Ramadoss, Nitya S, Basom, Ryan, Kim, Peter S, Finzi, Andrés, Overbaugh, Julie

“…Antibodies that mediate killing of HIV-infected cells through antibody-dependent cellular cytotoxicity (ADCC) have been implicated in protection from HIV…”
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Integrating Perspectives on Family Caregiving After Critical Illness: A Qualitative Content Analysis by Moale, Amanda C, Motter, Erica M, Eisenhauer, Peter, Gandhi, Nimit, Kim, S Peter, Girard, Tim D, Reynolds, 3rd, Charles F, Leland, Natalie E, Chang, Judy C, Scheunemann, Leslie P

“…To date, no intervention has definitively improved outcomes for families of critical illness survivors. An integrated perspective on caregivers' needs after…”
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Efficacy of a nucleoside-sparing regimen of darunavir/ ritonavir plus raltegravir in treatment-naive HIV-1-infected patients (ACTG A5262) by TAIWO, Babafemi, LU ZHENG, ERON, Joseph J, GALLIEN, Sebastien, MATINING, Roy M, KURITZKES, Daniel R, WILSON, Cara C, BERZINS, Baiba I, ACOSTA, Edward P, BASTOW, Barbara, KIM, Peter S

“…To explore darunavir/ritonavir (DRV/r) plus raltegravir (RAL) combination therapy in antiretroviral-naive patients. Phase IIb, single-arm, open-label,…”
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A1C Underestimates Glycemia in HIV Infection by Kim, Peter S, Woods, Christian, Georgoff, Patrick, Crum, Dana, Rosenberg, Alice, Smith, Margo, Hadigan, Colleen

“…OBJECTIVE: The objective of this study was to determine the relationship between A1C and glycemia in HIV infection. RESEARCH DESIGN AND METHODS: We completed a…”
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Ensuring impact of long‐acting HIV therapeutics through multi‐level treatment research: a view from NIH by Kim, Peter S., Stirratt, Michael J., Morton, Tia M., Rausch, Dianne M.

“…Clinical strategies to enable treatment experienced PWH to benefit from LAEDs, including LAED treatment initiation without prior viral suppression using oral…”
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Mature Dendritic Cells May Promote High-Avidity Tuning of Vaccine T Cell Responses by Kumbhari, Adarsh, Egelston, Colt A, Lee, Peter P, Kim, Peter S

“…Therapeutic vaccines can elicit tumor-specific cytotoxic T lymphocytes (CTLs), but durable reductions in tumor burden require vaccines that stimulate…”
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