Search Results - "KIM, Harry K. W"

Comprehensive Genome-Wide Transcriptomic Analysis of Immature Articular Cartilage following Ischemic Osteonecrosis of the Femoral Head in Piglets by Adapala, Naga Suresh, Kim, Harry K W

“…Ischemic osteonecrosis of the femoral head (ONFH) in piglets results in an ischemic injury to the immature articular cartilage. The molecular changes in the…”
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Development of a Mouse Model of Ischemic Osteonecrosis by Kamiya, Nobuhiro, Yamaguchi, Ryosuke, Aruwajoye, Olumide, Adapala, Naga Suresh, Kim, Harry K. W.

“…Background Availability of a reliable mouse model of ischemic osteonecrosis could accelerate the development of novel therapeutic strategies to stimulate bone…”
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Fat Phagocytosis Promotes Anti-Inflammatory Responses of Macrophages in a Mouse Model of Osteonecrosis by Deng, Zhuo, Kim, Harry K W, Hernandez, Paula A, Ren, Yinshi

“…Osteonecrosis (ON) of the femoral head (ONFH) is a devastating bone disease affecting over 20 million people worldwide. ONFH is caused by a disruption of the…”
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Enhanced Interfacial Adhesion and Osteogenesis for Rapid “Bone-like” Biomineralization by PECVD-Based Silicon Oxynitride Overlays by Ilyas, Azhar, Lavrik, Nickolay V, Kim, Harry K. W, Aswath, Pranesh B, Varanasi, Venu G

“…Structurally unstable fracture sites require metal fixative devices, which have long healing times due to their lack of osteoinductivity. Bioactive glass…”
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High-concentration of BMP2 reduces cell proliferation and increases apoptosis via DKK1 and SOST in human primary periosteal cells by Kim, Harry K.W, Oxendine, Ila, Kamiya, Nobuhiro

“…Abstract BMP2, a well-known osteoinductive agent approved by FDA, is currently being used for various off-label orthopedic applications. Recently, concerns…”
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Amorphous Silica: A New Antioxidant Role for Rapid Critical-Sized Bone Defect Healing by Ilyas, Azhar, Odatsu, Tetsuro, Shah, Ami, Monte, Felipe, Kim, Harry K. W., Kramer, Philip, Aswath, Pranesh B., Varanasi, Venu G.

“…Traumatic fractures cause structurally unstable sites due to severe bone loss. Such fractures generate a high yield of reactive oxygen species (ROS) that can…”
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Effects of Non-Weight-Bearing on the Immature Femoral Head Following Ischemic Osteonecrosis: An Experimental Investigation in Immature Pigs by Kim, Harry K.W, Aruwajoye, Olumide, Stetler, Jeffrey, Stall, Alec

“…BACKGROUND:Local non-weight-bearing as a treatment for Legg-Calvé-Perthes disease remains controversial since a clear scientific basis for this treatment is…”
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Local BMP2 hydrogel therapy for robust bone regeneration in a porcine model of Legg-Calvé-Perthes disease by Ma, Chi, Park, Min Sung, Alves do Monte, Felipe, Gokani, Vishal, Aruwajoye, Olumide O., Ren, Yinshi, Liu, Xiaohua, Kim, Harry K. W.

“…Legg-Calvé-Perthes disease is juvenile idiopathic osteonecrosis of the femoral head (ONFH) that has no effective clinical treatment. Previously, local…”
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Legg‐Calvé‐Perthes Disease Produces Chronic Hip Synovitis and Elevation of Interleukin‐6 in the Synovial Fluid by Kamiya, Nobuhiro, Yamaguchi, Ryosuke, Adapala, Naga Suresh, Chen, Elena, Neal, David, Jack, Obrien, Thoveson, Alec, Gudmundsson, Paul, Brabham, Case, Aruwajoye, Olumide, Drissi, Hicham, Kim, Harry KW

“…ABSTRACT Legg‐Calvé‐Perthes disease (LCPD) is a childhood hip disorder of ischemic osteonecrosis of the femoral head. Hip joint synovitis is a common feature…”
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Bone Apatite Composition of Necrotic Trabecular Bone in the Femoral Head of Immature Piglets by Aruwajoye, Olumide O., Kim, Harry K. W., Aswath, Pranesh B.

“…Ischemic osteonecrosis of the femoral head (IOFH) can lead to excessive resorption of the trabecular bone and collapse of the femoral head as a structure. A…”
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Local Administration of Ibandronate and Bone Morphogenetic Protein-2 After Ischemic Osteonecrosis of the Immature Femoral Head: A Combined Therapy That Stimulates Bone Formation and Decreases Femoral Head Deformity by Vandermeer, Jacob S, Kamiya, Nobuhiro, Aya-ay, James, Garces, Amanda, Browne, Richard, Kim, Harry K.W

“…BACKGROUND:Bisphosphonate therapy has been shown to preserve the osteonecrotic femoral head in experimental and short-term clinical studies. However, a lack of…”
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Regulation of bone and skeletal development by the SHP-2 protein tyrosine phosphatase by Kamiya, Nobuhiro, Kim, Harry K.W, King, Philip D

“…Abstract Src homology-2 protein tyrosine phosphatase (SHP-2) that is encoded by the PTPN11 gene in humans is an intracellular signaling molecule that couples…”
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RANKL Inhibition: A Novel Strategy to Decrease Femoral Head Deformity After Ischemic Osteonecrosis by Kim, Harry KW, Morgan‐Bagley, Stephanie, Kostenuik, Paul

“…A novel therapeutic strategy to decrease the development of femoral head deformity after ischemic osteonecrosis was studied in a large animal model of total…”
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Moderate Weightbearing Restrictions Are Associated with Worse Depressive Symptoms and Anxiety in Children Aged 5 to 7 Years with Perthes Disease by Do, Dang-Huy, Valencia, Angel A., Jo, Chan-hee, Kim, Harry K. W.

“…Perthes disease most commonly affects children 5 to 7 years old, and nonoperative management, such as weightbearing and activity restrictions, is generally…”
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Development of a murine model of ischemic osteonecrosis to study the effects of aging on bone repair by Yamaguchi, Ryosuke, Kamiya, Nobuhiro, Kuroyanagi, Gen, Ren, Yinshi, Kim, Harry K. W.

“…Age at onset is one of the most important predictors of outcome following ischemic osteonecrosis (ON). Currently, there is no well‐established animal model to…”
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How Much Varus Is Optimal with Proximal Femoral Osteotomy to Preserve the Femoral Head in Legg-Calvé-Perthes Disease? by Kim, Harry K.W, da Cunha, Ana Munhoz, Browne, Richard, Kim, Hui Taek, Herring, J Anthony

“…BACKGROUND:Although proximal femoral varus osteotomy is an established operative treatment for Legg-Calvé-Perthes disease, there is a lack of data on how much…”
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Retention, Distribution, and Effects of Intraosseously Administered Ibandronate in the Infarcted Femoral Head by Aya‐ay, James, Athavale, Sanjay, Morgan‐Bagley, Stephanie, Bian, Haikuo, Bauss, Frieder, Kim, Harry KW

“…The local distribution, retention, and effects of intraosseous administration of ibandronate in the infarcted femoral heads were studied. Intraosseous…”
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Intraosseous Delivery of Bone Morphogenic Protein‑2 Using a Self-Assembling Peptide Hydrogel by Phipps, Matthew C, Monte, Felipe, Mehta, Manav, Kim, Harry K. W

“…Osteonecrosis of the femoral head (ONFH) is a debilitating hip disorder, which often produces a permanent femoral head deformity and osteoarthritis. The local…”
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Weightbearing and Activity Restriction Treatments and Quality of Life in Patients with Perthes Disease by Do, Dang-Huy, McGuire, Molly F., Jo, Chan-hee, Kim, Harry K. W.

“…Weightbearing and activity restrictions are commonly prescribed during the active stages of Perthes disease. These restrictions, ranging from cast or brace…”
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Effects of Disruption of Epiphyseal Vasculature on the Proximal Femoral Growth Plate by Kim, Harry K.W, Stephenson, Natalie, Garces, Amanda, Aya-ay, James, Bian, Haikuo

“…BackgroundProximal femoral growth disturbance is a major complication associated with ischemic osteonecrotic conditions, such as Legg-Calvè-Perthes disease…”
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