Search Results - "KILPATRICK, B. F"

Four New Clerodane Diterpenes from the Leaves of Casearia guianensis Which Inhibit the Interaction of Leukocyte Function Antigen 1 with Intercellular Adhesion Molecule 1 by Hunter, Margie S, Corley, David G, Carron, Christopher P, Rowold, Edwin, Kilpatrick, Brian F, Durley, Richard C

“…Four new clerodane diterpenes, casearinols A and B (1 and 2) and casearinones A and B (3 and 4), were isolated from the leaves of Casearia guianensis. These…”
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Agonist binding promotes a guanine nucleotide reversible increase in the apparent size of the bovine anterior pituitary dopamine receptors by Kilpatrick, B F, Caron, M G

“…Dopamine receptors, solubilized from bovine anterior pituitary membranes with the detergent digitonin, retained a typical dopaminergic specificity for the…”
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A high-throughput assay for cyclic nucleotide phosphodiesterases by Schilling, R J, Morgan, D R, Kilpatrick, B F

“…The search for cyclic nucleotide phosphodiesterase inhibitors in large chemical and natural product libraries is limited by assay throughput. A high-throughput…”
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Dopaminergic inhibition of adenylate cyclase correlates with high affinity agonist binding to anterior pituitary D2 dopamine receptors by McDonald, W M, Sibley, D R, Kilpatrick, B F, Caron, M G

“…Dopamine (DA) and the dopaminergic agonists n-propylnorapomorphine (NPA), 2-amino-6,7-dihydroxytetrahydronaphthalene (ADTN) and apomorphine (APO) inhibit…”
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AHR-14310C: a potent, long-acting, nonsedating H1-antihistamine that prevents antigen-induced mucus formation in sensitive rats by Nolan, J C, Foxwell, M H, Whitman, L L, Yanni, J M, Walsh, D A, Kilpatrick, B F, Johnson, D N, Proakis, A G

“…AHR-14310C(5-[2-[4-[bis(4-fluorophenyl)hydroxymethyl- 1-piperidinyl]ethyl]-3-methyl]-2-oxazolidinone ethanedioate, hydrochloride salt) displays potent and…”
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Use of procainamide gels in the purification of human and horse serum cholinesterases by Ralston, J S, Main, A R, Kilpatrick, B F, Chasson, A L

“…Two large-scale methods based primarily on the use of procainamide-Sepharose gels were developed for the purification of horse and human serum non-specific…”
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Optical isomers of rocastine and close analogs: synthesis and H1 antihistaminic activity of its enantiomers and their structural relationship to the classical antihistamines by Sleevi, Mark C, Cale, Albert D, Gero, Thomas W, Jaques, Larry W, Welstead, William J, Johnson, Ashby F, Kilpatrick, Brian F, Demian, Iulia, Nolan, Joseph C, Jenkins, Herndon

“…The enantiomers of 2-[2-(dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4- oxazapine-5(2H)-thione (rocastine) and two of its more potent analogues…”
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Characterization of the recombinant IKK1/IKK2 heterodimer. Mechanisms regulating kinase activity by Huynh, Q K, Boddupalli, H, Rouw, S A, Koboldt, C M, Hall, T, Sommers, C, Hauser, S D, Pierce, J L, Combs, R G, Reitz, B A, Diaz-Collier, J A, Weinberg, R A, Hood, B L, Kilpatrick, B F, Tripp, C S

“…Nuclear factor kappa B (NF-kappaB) is a ubiquitous, inducible transcription factor that regulates the initiation and progression of immune and inflammatory…”
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Dopamine receptor of the porcine anterior pituitary gland. Solubilization and characterization by Kilpatrick, B F, Caron, M G

“…In the anterior pituitary gland, dopamine controls the release of prolactin from the mammotrophs. The dopamine receptors in the porcine gland have been shown…”
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Dopamine receptor of the porcine anterior pituitary gland. Effects of N-ethylmaleimide and heat on ligand binding mimic the effects of guanine nucleotides by Kilpatrick, B F, De Lean, A, Caron, M G

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Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase by Penning, T D, Chandrakumar, N S, Chen, B B, Chen, H Y, Desai, B N, Djuric, S W, Docter, S H, Gasiecki, A F, Haack, R A, Miyashiro, J M, Russell, M A, Yu, S S, Corley, D G, Durley, R C, Kilpatrick, B F, Parnas, B L, Askonas, L J, Gierse, J K, Harding, E I, Highkin, M K, Kachur, J F, Kim, S H, Krivi, G G, Villani-Price, D, Pyla, E Y, Smith, W G

“…Leukotriene B(4) (LTB(4)) is a pro-inflammatory mediator that has been implicated in the pathogenesis of a number of diseases including inflammatory bowel…”
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Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems by Cerione, Richard A, Codina, Juan, Kilpatrick, Brian F, Staniszewski, Claudia, Gierschik, Peter, Somers, Robert L, Spiegel, Allen M, Birnbaumer, Lutz, Caron, Marc G, Lefkowitz, Robert J

“…The adenylate cyclase coupled inhibitory nucleotide regulatory protein (Ni) and the bovine retinal nucleotide regulatory protein transducin (T) appear to share…”
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A novel radioiodinated high affinity ligand for the D2-dopamine receptor: characterization of its binding in bovine anterior pituitary membranes by NOURDINE AMLAIKY, KILPATRICK, B. F, CARON, M. G

“…A novel high affinity dopaminergic ligand, N-(p-aminophenethyl)spiroperidol, has been synthesized and radioiodinated to a specific radioactivity of 2175…”
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AHR-12245: a potential anti-absence drug by Johnson, D N, White, H S, Swinyard, E A, Albertson, T E, Kilpatrick, B F

“…AHR-12245, 2-(4-chlorophenyl)-3H-imadazo[4,5-b]pyridine-3-acetamid, ethosuximide, Na valproate, phenytoin, and clonazepam were evaluated in mice and rats with…”
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Inhibition of two monomeric butyrylcholinesterases from rabbit liver by chlorpromazine and other drugs by Rush, R S, Main, A R, Kilpatrick, B F, Faulkner, G D

“…A new form of cholinesterases has been discovered in rabbit liver; the new enzymes are monomeric butyrylcholinesterases (EC 3.1.1.8), mBuChE I and mBuChE II…”
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AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels by Barrett, R J, Appell, K C, Kilpatrick, B F, Proakis, A G, Nolan, J C, Walsh, D A

“…In vivo and in vitro methods were used to characterize AHR-16303B, a novel compound with antagonistic action at 5-HT2 receptors and voltage-sensitive calcium…”
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Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists by De Lean, A, Kilpatrick, B F, Caron, M G

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2-phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics by TOMCZUK, B. E, TAYLOR, C. R, MOSES, L. M, SUTHERLAND, D. B, LO, Y. S, JOHNSON, D. N, KINNIER, W. B, KILPATRICK, B. F

“…A series of 2-phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides were designed and synthesized as non-benzodiazepine anxiolytics based on a molecular disconnection…”
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Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine by Nolan, J C, Stephens, D J, Proakis, A G, Leonard, C A, Johnson, D N, Kilpatrick, B F, Foxwell, M H, Yanni, J M

“…Rocastine [AHR-11325, 2-[2-(dimethylamino)ethyl]-2,3-dihydro-4-methylpyrido-[3,2-f]-1,4- oxazepine-5(4H)-thione (E)-2-butenedioate)] is a rapid-acting, potent,…”
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Isolation and Structure of Leukotriene-A4 Hydrolase Inhibitor:  8(S)-Amino-2(R)-methyl-7-oxononanoic Acid Produced by Streptomyces diastaticus by Parnas, Barry L, Durley, Richard C, Rhoden, Eric E, Kilpatrick, Brian F, Makkar, Narinder, Thomas, Kristin E, Smith, Walter G, Corley, David G

“…The novel amino acid 8(S)-amino-2(R)-methyl-7-oxononanoic acid (1) was isolated from the soil-borne microorganism Streptomyces diastaticus during our screening…”
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