Search Results - "KILLINGSWORTH, Cheryl"

Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog by Zheng, Junying, Wei, Chih-Chang, Hase, Naoki, Shi, Ke, Killingsworth, Cheryl R, Litovsky, Silvio H, Powell, Pamela C, Kobayashi, Tsunefumi, Ferrario, Carlos M, Rab, Andras, Aban, Inmaculada, Collawn, James F, Dell'Italia, Louis J

“…Cardiac ischemia and reperfusion (I/R) injury occurs because the acute increase in oxidative/inflammatory stress during reperfusion culminates in the death of…”
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Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine by McILwain, R Britt, Timpa, Joseph G, Kurundkar, Ashish R, Holt, David W, Kelly, David R, Hartman, Yolanda E, Neel, Mary Lauren, Karnatak, Rajendra K, Schelonka, Robert L, Anantharamaiah, G M, Killingsworth, Cheryl R, Maheshwari, Akhil

“…Extracorporeal membrane oxygenation (ECMO) is a life-saving support system used in neonates and young children with severe cardiorespiratory failure. Although…”
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Imaging cardiac activation sequence during ventricular tachycardia in a canine model of nonischemic heart failure by Han, Chengzong, Pogwizd, Steven M, Yu, Long, Zhou, Zhaoye, Killingsworth, Cheryl R, He, Bin

“…Noninvasive cardiac activation imaging of ventricular tachycardia (VT) is important in the clinical diagnosis and treatment of arrhythmias in heart failure…”
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Noninvasive reconstruction of the three-dimensional ventricular activation sequence during pacing and ventricular tachycardia in the canine heart by Han, Chengzong, Pogwizd, Steven M, Killingsworth, Cheryl R, He, Bin

“…Single-beat imaging of myocardial activation promises to aid in both cardiovascular research and clinical medicine. In the present study we validate a…”
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Noninvasive cardiac activation imaging of ventricular arrhythmias during drug-induced QT prolongation in the rabbit heart by Han, Chengzong, PhD, Pogwizd, Steven M., MD, Killingsworth, Cheryl R., PhD, Zhou, Zhaoye, BS, He, Bin, PhD

“…Background Imaging myocardial activation from noninvasive body surface potentials promises to aid in both cardiovascular research and clinical medicine…”
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Morning surge of ventricular arrhythmias in a new arrhythmogenic canine model of chronic heart failure is associated with attenuation of time-of-day dependence of heart rate and autonomic adaptation, and reduced cardiac chaos by Zhu, Yujie, Hanafy, Mohamed A, Killingsworth, Cheryl R, Walcott, Gregory P, Young, Martin E, Pogwizd, Steven M

“…Patients with chronic heart failure (CHF) exhibit a morning surge in ventricular arrhythmias, but the underlying cause remains unknown. The aim of this study…”
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Noninvasive imaging of three-dimensional cardiac activation sequence during pacing and ventricular tachycardia by Han, Chengzong, MS, Pogwizd, Steven M., MD, Killingsworth, Cheryl R., PhD, He, Bin, PhD

“…Background Imaging cardiac excitation within ventricular myocardium is important in the treatment of cardiac arrhythmias and might help improve our…”
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IND-Directed Safety and Biodistribution Study of Intravenously Injected Cetuximab-IRDye800 in Cynomolgus Macaques by Zinn, Kurt R., Korb, Melissa, Samuel, Sharon, Warram, Jason M., Dion, David, Killingsworth, Cheryl, Fan, Jinda, Schoeb, Trenton, Strong, Theresa V., Rosenthal, Eben L.

“…Purpose The use of receptor-targeted antibodies conjugated to fluorophores is actively being explored for real-time imaging of disease states; however, the…”
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Activation patterns of purkinje fibers during long-duration ventricular fibrillation in an isolated canine heart model by TABEREAUX, Paul B, WALCOTT, Greg P, ROGERS, Jack M, KIM, Jong, DOSDALL, Derek J, ROBERTSON, Peter G, KILLINGSWORTH, Cheryl R, SMITH, William M, IDEKER, Raymond E

“…The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF…”
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Evaluation of Acute Cardiac and Chest Wall Damage after Shocks with a Subcutaneous Implantable Cardioverter Defibrillator in Swine by KILLINGSWORTH, CHERYL R., MELNICK, SHARON B., LITOVSKY, SILVIO H., IDEKER, RAYMOND E., WALCOTT, GREGORY P.

“…Background A subcutaneous implantable cardioverter defibrillator (S‐ICD) could ease placement and reduce complications of transvenous ICDs, but requires more…”
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Chemical ablation of the Purkinje system causes early termination and activation rate slowing of long-duration ventricular fibrillation in dogs by Dosdall, Derek J, Tabereaux, Paul B, Kim, Jong J, Walcott, Gregory P, Rogers, Jack M, Killingsworth, Cheryl R, Huang, Jian, Robertson, Peter G, Smith, William M, Ideker, Raymond E

“…Endocardial mapping has suggested that Purkinje fibers may play a role in the maintenance of long-duration ventricular fibrillation (LDVF). To determine the…”
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Extracorporeal Membrane Oxygenation Causes Loss of Intestinal Epithelial Barrier in the Newborn Piglet by Kurundkar, Ashish R, Killingsworth, Cheryl R, McIlwain, R Britt, Timpa, Joseph G, Hartman, Yolanda E, He, Dongning, Karnatak, Rajendra K, Neel, Mary L, Clancy, John P, Anantharamaiah, G M, Maheshwari, Akhil

“…Extracorporeal membrane oxygenation (ECMO) is an important life-support system used in neonates and young children with intractable cardiorespiratory failure…”
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Intestinal epithelial apoptosis initiates gut mucosal injury during extracorporeal membrane oxygenation in the newborn piglet by MohanKumar, Krishnan, Killingsworth, Cheryl R, Britt McILwain, R, Timpa, Joseph G, Jagadeeswaran, Ramasamy, Namachivayam, Kopperuncholan, Kurundkar, Ashish R, Kelly, David R, Garzon, Steven A, Maheshwari, Akhil

“…Neonates and young infants exposed to extracorporeal circulation during extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass are at risk of…”
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Ascending-Ramp Biphasic Waveform Has a Lower Defibrillation Threshold and Releases Less Troponin I Than a Truncated Exponential Biphasic Waveform by JIAN HUANG, WALCOTT, Gregory P, RUSE, Richard B, BOHANAN, Scott J, KILLINGSWORTH, Cheryl R, IDEKER, Raymond E

“…We tested the hypothesis that the shape of the shock waveform affects not only the defibrillation threshold but also the amount of cardiac damage…”
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Flexor Tendon Repair With a Knotless, Bidirectional Barbed Suture: An In Vivo Biomechanical Analysis by Maddox, Grady E., MD, Ludwig, Jonathan, MD, Craig, Eric R., BS, Woods, David, BS, Joiner, Aaron, BA, Chaudhari, Nilesh, MD, Killingsworth, Cheryl, DVM, PhD, Siegal, Gene P., MD, PhD, Eberhardt, Alan, PhD, Ponce, Brent, MD

“…Purpose To compare and analyze biomechanical properties and histological characteristics of flexor tendons either repaired by a 4-strand modified Kessler…”
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Low Intensity Shear Stress Increases Endothelial ELR+ CXC Chemokine Production via a Focal Adhesion Kinase-p38β MAPK-NF-κB Pathway by Shaik, Sadiq S., Soltau, Thomas D., Chaturvedi, Gaurav, Totapally, Balagangadhar, Hagood, James S., Andrews, William W., Athar, Mohammad, Voitenok, Nikolai N., Killingsworth, Cheryl R., Patel, Rakesh P., Fallon, Michael B., Maheshwari, Akhil

“…CXC chemokines with a glutamate-leucine-arginine (ELR) tripeptide motif (ELR+ CXC chemokines) play an important role in leukocyte trafficking into the tissues…”
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Developmental changes in circulating IL-8/CXCL8 isoforms in neonates by Maheshwari, Akhil, Voitenok, Nikolai N., Akalovich, Svetlana, Shaik, Sadiq S., Randolph, David A., Sims, Brian, Patel, Rakesh P., Killingsworth, Cheryl R., Fallon, Michael B., Ohls, Robin K.

“…Interleukin-8 (IL-8/CXCL8) is widely expressed in fetal tissues although inflammatory changes are not seen. Circulating IL-8 is comprised of an…”
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Do clinically relevant transthoracic defibrillation energies cause myocardial damage and dysfunction? by Walcott, Gregory P., Killingsworth, Cheryl R., Ideker, Raymond E.

“…Sufficiently strong defibrillation shocks will cause temporary or permanent damage to the heart. Weak defibrillation shocks do not cause any damage to the…”
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Evolution of activation patterns during long-duration ventricular fibrillation in dogs by Huang, Jian, Rogers, Jack M, Killingsworth, Cheryl R, Singh, Karan P, Smith, William M, Ideker, Raymond E

“…Although resuscitation for sudden cardiac arrest attempts are frequently not instituted for several minutes after the onset of ventricular fibrillation (VF),…”
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Inhaled Concentrated Ambient Particles Are Associated with Hematologic and Bronchoalveolar Lavage Changes in Canines by Clarke, Robert W., Coull, Brent, Reinisch, Ulrike, Catalano, Paul, Killingsworth, Cheryl R., Koutrakis, Petros, Kavouras, Ilias, Gopala Gazula Krishna Murthy, Lawrence, Joy, Lovett, Eric, Wolfson, J. Mikhail, Verrier, Richard L., Godleski, John J.

“…Pulmonary inflammatory and hematologic responses of canines were studied after exposure to concentrated ambient particles (CAPs) using the Harvard ambient…”
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