Effects of extra—corporeal shock waves on penile hemodynamics and histopathology in rats

Aim:To study the effect of extra-corporeal shock wave(ESW) on the penile hemodynamics and histopathology in rats.Methods:Adult male Sprague-Dawley rats were divided at random into 3 groups.ESW application was performed with a siemens Lithostar with the rats under anesthesia lying prone on the balloo...

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Published in:	Asian journal of andrology Vol. 4; no. 4; pp. 249 - 253
Main Authors:	TEFEKLI, Ahmet, ARMAGAN, Abdullah, EROL, Bulent, CELTIK, Murat, KILICASLAN, Isi, NURTEN, Asiye, KADIOGLU, Ates
Format:	Journal Article
Language:	English
Published:	Oxford blackwell 01-12-2002
Subjects:	Animals Biological and medical sciences Blood Pressure - radiation effects Electric Stimulation Genital system. Mammary gland Hemodynamics High-Energy Shock Waves Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Penile Erection - physiology Penile Erection - radiation effects Penis - blood supply Penis - innervation Penis - pathology Penis - radiation effects Rats Rats, Sprague-Dawley 体外冲击波组织病理学血液动力学 Rat Rodentia Smooth muscle Extracorporeal circuit Wall thickness Shock wave Pathology Penile diseases Vertebrata Mammalia Histopathology Penis Animal Hemodynamics Male genital diseases
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Summary:	Aim:To study the effect of extra-corporeal shock wave(ESW) on the penile hemodynamics and histopathology in rats.Methods:Adult male Sprague-Dawley rats were divided at random into 3 groups.ESW application was performed with a siemens Lithostar with the rats under anesthesia lying prone on the balloon probe.Rats in Group I received a total of 1000 shocks at 18kV and immediately underwent hemodynamic evaluation performed by direct electrostimulation of the cavernous nerve and measurement of intracavernous pressure (ICP).Rats in Group Ⅱ received 3 times 1000 shocks at 18kV at weekly intervals and hemodynamic evaluation was performed 1 month after the last ESW application.Group Ⅲ served as the control.Histopathological examinations of penile tissues were done on Masson's trichrome and hematoxylin and eosin stained sections.Results:Penile hemodynamic evaluation showed a trend toward a diminished mean maximal ICP,duration of erection,ICP during the plateau phase and maximal ICP/blood pressure ratio in Group I,although there was no significant significance.The mean latency period in Groups I and Ⅱ was prolonged.Petechial bleeding within tunical layers and small foci of hemorrhage within the corpora cavernosa were observed in Group I.However,Histopathological examination failed to reveal any significant differences between the groups in terms of smooth muscle content,tunical thickness,organization of collagen bundles and elastic fiber-lattice framework.Conclusion:ESW has certain damaging effects on the penis.
Bibliography:	R697.1 31-1795/R ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1008-682X 1745-7262