Search Results - "KILGORE, Michael W"

Specific thiazolidinediones inhibit ovarian cancer cell line proliferation and cause cell cycle arrest in a PPARγ independent manner by Al-Alem, Linah, Southard, R Chase, Kilgore, Michael W, Curry, Thomas E

“…Peroxisome Proliferator Activated Receptor gamma (PPARγ) agonists, such as the thiazolinediones (TZDs), have been studied for their potential use as cancer…”
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Signal cross-talk between estrogen receptor alpha and beta and the peroxisome proliferator-activated receptor gamma1 in MDA-MB-231 and MCF-7 breast cancer cells by Wang, Xin, Kilgore, Michael W.

“…We have previously demonstrated that peroxisome proliferator-activated receptor gamma (PPARγ) is expressed and transcriptionally responsive to both synthetic…”
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Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells by Zaytseva, Yekaterina Y, Wang, Xin, Southard, R Chase, Wallis, Natalie K, Kilgore, Michael W

“…Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily and is highly expressed in many human…”
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Activation of the PKC Pathway Stimulates Ovarian Cancer Cell Proliferation, Migration, and Expression of MMP7 and MMP10 by AL-ALEM, Linah F, MCCORD, Lauren A, SOUTHARD, R. Chase, KILGORE, Michael W, CURRY, Thomas E

“…Postmenopausal women are at a higher risk of ovarian cancer due, in part, to increased levels of gonadotropins such as luteinizing hormone (LH). Gonadotropins…”
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Distinct modulation of voltage‐gated and ligand‐gated Ca2+ currents by PPAR‐γ agonists in cultured hippocampal neurons by Pancani, Tristano, Phelps, Jeremiah T., Searcy, James L., Kilgore, Michael W., Chen, Kuey‐Chu, Porter, Nada M., Thibault, Olivier

“…Type 2 diabetes mellitus is a metabolic disorder characterized by hyperglycemia and is especially prevalent in the elderly. Because aging is a risk factor for…”
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Oxa-Enediynes:  Probing the Electronic and Stereoelectronic Contributions to the Bergman Cycloaromatization by Jones, Graham B, Wright, Justin M, Hynd, George, Wyatt, Justin K, Warner, Philip M, Huber, Robert S, Li, Aiwen, Kilgore, Michael W, Sticca, Robert P, Pollenz, Richard S

“…Efficient routes to three classes of 10-membered oxa-enediynes are presented. The electronic and stereoelectronic contributions to half-lives are supported by…”
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MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response by Kilgore, Michael W, Tate, Patricia L, Rai, Sudha, Sengoku, Eiichi, Price, Thomas M

“…Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that regulate transcription of target genes. Since attempts have…”
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Activation of the PKC Pathway Stimulates Ovarian Cancer Cell Proliferation, Migration, and Expression of MMP7 and MMP101 by Al-Alem, Linah F, McCord, Lauren A, Southard, R. Chase, Kilgore, Michael W, Curry, Thomas E

“…Postmenopausal women are at a higher risk of ovarian cancer due, in part, to increased levels of gonadotropins such as luteinizing hormone (LH). Gonadotropins…”
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MAZ drives tumor-specific expression of PPAR gamma 1 in breast cancer cells by Wang, Xin, Southard, R. Chase, Allred, Clinton D., Talbert, Dominique R., Wilson, Melinda E., Kilgore, Michael W.

“…The peroxisome proliferator-activated receptor gamma 1 (PPARγ1) is a nuclear receptor that plays a pivotal role in breast cancer and is highly over-expressed…”
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The Increased Expression of Peroxisome Proliferator-Activated Receptor-γ1 in Human Breast Cancer Is Mediated by Selective Promoter Usage by Wang, Xin, Southard, R. Chase, Kilgore, Michael W.

“…Peroxisome proliferator-activated receptor-γ1 (PPARγ1) is transactivated by a wide range of ligands in normal human mammary epithelial and breast cancer cells…”
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Ad4BP/SF-1 Regulates Cyclic AMP-induced Transcription from the Proximal Promoter (PII) of the Human Aromatase P450 (CYP19) Gene in the Ovary by Michael, M. Dodson, Kilgore, Michael W., Morohashi, Ken-ichirou, Simpson, Evan R.

“…Aromatase P450, which is responsible for the metabolism of C19 steroids to estrogens, is expressed in the pre-ovulatory follicles and corpora lutea of…”
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Target-Directed Enediynes:  Designed Estramycins by Jones, Graham B, Hynd, George, Wright, Justin M, Purohit, Ajay, Plourde, Gary W, Huber, Robert S, Mathews, Jude E, Li, Aiwen, Kilgore, Michael W, Bubley, Glenn J, Yancisin, Molly, Brown, Myles A

“…The goal of selective targeting of enediyne cytotoxins has been investigated using estrogenic delivery vehicles. A series of estrogen−enediyne conjugates were…”
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Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues by Means, G D, Kilgore, M W, Mahendroo, M S, Mendelson, C R, Simpson, E R

“…The formation of estrogens from C19 steroids is catalyzed by a specific form of cytochrome P450, aromatase cytochrome P450 (P450AROM; the product of the CYP19…”
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Selective activation of PPARγ in breast, colon, and lung cancer cell lines by Allred, Clinton D., Kilgore, Michael W.

“…Peroxisome proliferator-activated receptor gamma (PPARγ) plays a critical albeit poorly defined role in the development and progression of several cancer types…”
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Transactivation of ERα by Rosiglitazone induces proliferation in breast cancer cells by Talbert, Dominique R., Allred, Clinton D., Zaytseva, Yekaterina Y., Kilgore, Michael W.

“…In the present study, we demonstrate that Rosiglitazone (Rosi), a thiazolidinedione and PPARγ agonist, induces ERE (Estrogen Receptor Response Element)…”
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Defining Thiazolidinedione Targets in Ovarian Cancer to Identify Novel Diagnostic Markers by Al-Alem, Linah F., Southard, R. Chase, Kilgore, Michael W., Zhu, Haining, Curry, Thomas E.

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Specific Thiazolidinediones Inhibit Ovarian Cancer Cell Line Proliferation and Cause Cell Cycle Arrest in a PPAR[gamma] Independent Manner by Al-Alem, Linah, Southard, R. Chase, Kilgore, Michael W, Curry, Thomas E

“…Background Peroxisome Proliferator Activated Receptor gamma (PPAR[gamma]) agonists, such as the thiazolinediones (TZDs), have been studied for their potential…”
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Abstract 1723: Thiazolinediones (TZDs) mediate proliferation and cell cycle kinetics in ovarian cancer cells in a PPARγ-dependent and -independent manner by Al-Alem, Linah F., Southard, Chase R., Kilgore, Michael W., Curry, Thomas E.

“…Ovarian cancer is the leading cause of death in women with gynecological malignancies and is often called the ‘silent killer’. Thus, new treatment targets are…”
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PPARα Ligands Reduce PCB-Induced Endothelial Activation: Possible Interactions in Inflammation and Atherosclerosis by Arzuaga, Xabier, Reiterer, Gudrun, Majkova, Zuzana, Kilgore, Michael W., Toborek, Michal, Hennig, Bernhard

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Initial characterization of a subclone of the MA-10 mouse Leydig tumor cell line by Kilgore, M W, Stocco, D M

“…Cloned cell lines have proven to be useful models in understanding the regulation of endocrine cells and steroid synthesis. In this study we report the…”
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