Search Results - "KIKKAWA, R"

Polarization-based branch selection of bound states in the continuum in dielectric waveguide modes anti-crossed by a metal grating by Kikkawa, R, Nishida, M, Kadoya, Y

“…We investigate bound states in the continuum (BICs) in a planar dielectric waveguide structure consisting of a gold grating on a dielectric layer with a back…”
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Long-term effect of modification of dietary protein intake on the progression of diabetic nephropathy: a randomised controlled trial by Koya, D, Haneda, M, Inomata, S, Suzuki, Y, Suzuki, D, Makino, H, Shikata, K, Murakami, Y, Tomino, Y, Yamada, K, Araki, S. I, Kashiwagi, A, Kikkawa, R

“…Aims/hypothesis There is currently insufficient evidence to recommend a low-protein diet for type 2 diabetic patients with diabetic nephropathy. We assessed…”
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Diabetic neuropathy and nerve regeneration by Yasuda, Hitoshi, Terada, Masahiko, Maeda, Kengo, Kogawa, Shuro, Sanada, Mitsuru, Haneda, Masakazu, Kashiwagi, Atsunori, Kikkawa, Ryuichi

“…Diabetic neuropathy is the most common peripheral neuropathy in western countries. Although every effort has been made to clarify the pathogenic mechanism of…”
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Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population by Maeda, S., Osawa, N., Hayashi, T., Tsukada, S., Kobayashi, M., Kikkawa, R.

“…Genetic susceptibility plays an important role in the pathogenesis of diabetic nephropathy and type II diabetes. To identify the genetic polymorphisms…”
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Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions by Haneda, M., Araki, S., Togawa, M., Sugimoto, T., Isono, M., Kikkawa, R.

“…Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions. M…”
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Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB by Obata, Toshiyuki, Yaffe, Michael B., Leparc, German G., Piro, Elizabeth T., Maegawa, Hiroshi, Kashiwagi, Atsunori, Kikkawa, Ryuichi, Cantley, Lewis C.

“…AKT was originally identified as a proto-oncogene with a pleckstrin homology and Ser/Thr protein kinase domains. Recent studies revealed that AKT regulates a…”
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Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta by SHINOZAKI, K, KASHIWAGI, A, NISHIO, Y, OKAMURA, T, YOSHIDA, Y, MASADA, M, TODA, N, KIKKAWA, R

“…Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta…”
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Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats by ISSHIKI, K, HANEDA, M, KOYA, D, MAEDA, S, SUGIMOTO, T, KIKKAWA, R

“…Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats. K Isshiki , M Haneda , D Koya ,…”
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Chronic complications in diabetes mellitus by KIKKAWA, Ryuichi

“…Diabetes mellitus is one of the most prevalent diseases among adult population in Japan. The persistent hyperglycemia is responsible for the appearance of…”
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Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes by Kanazawa, A, Kawamura, Y, Sekine, A, Iida, A, Tsunoda, T, Kashiwagi, A, Tanaka, Y, Babazono, T, Matsuda, M, Kawai, K, Iiizumi, T, Fujioka, T, Imanishi, M, Kaku, K, Iwamoto, Y, Kawamori, R, Kikkawa, R, Nakamura, Y, Maeda, S

“…Although genetic susceptibility plays an important role in the pathogenesis of type 2 diabetes, most of the genes that influence susceptibility to type 2…”
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Increase in intracellular Ca(2+) and calcitonin gene-related peptide release through metabotropic P2Y receptors in rat dorsal root ganglion neurons by Sanada, M, Yasuda, H, Omatsu-Kanbe, M, Sango, K, Isono, T, Matsuura, H, Kikkawa, R

“…We examined the effects of the activation of metabotropic P2Y receptors on the intracellular Ca(2+) concentration and the release of neuropeptide calcitonin…”
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Increase in intracellular Ca2+ and calcitonin gene-related peptide release through metabotropic P2Y receptors in rat dorsal root ganglion neurons by SANADA, M, YASUDA, H, OMATSU-KANBE, M, SANGO, K, ISONO, T, MATSUURA, H, KIKKAWA, R

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INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURES -"WHAT BIOMARKERS WOULD NEED TO BE ADDRESSED TO ESTIMATE TOXICITY IN CONVENTIONAL AND NEW APPROACHES?" by KIKKAWA, Rie, YAMAMOTO, Toshinori, FUKUSHIMA, Tamio, YAMADA, Hiroshi, HORII, Ikuo

“…High throughput toxicological estimation is required for safety evaluation in the early stage of drug discovery. In this context, establishment of an in vitro…”
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Cellular mechanisms in the development and progression of diabetic nephropathy: Activation of the DAG-PKC-ERK pathway by Haneda, Masakazu, Koya, Daisuke, Kikkawa, Ryuichi

“…Diabetic nephropathy is characterized functionally by glomerular hyperfiltration and albuminuria and histologically by the expansion of glomerular mesangium…”
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Tetrodotoxin-resistant sodium channels of dorsal root ganglion neurons are readily activated in diabetic rats by Hirade, M., Yasuda, H., Omatsu-Kanbe, M., Kikkawa, R., Kitasato, H.

“…To clarify the mechanism of hyperalgesia in diabetic neuropathy, we investigated the effects of streptozocin-induced hyperglycemia on tetrodotoxin-resistant Na…”
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Increased intestinal glucose absorption and postprandial hyperglycaemia at the early step of glucose intolerance in Otsuka Long-Evans Tokushima Fatty Rats by FUJITA, Y, KOJIMA, H, HIDAKA, H, FUJIMIYA, M, KASHIWAGI, A, KIKKAWA, R

“…Otsuka Long-Evans Tokushima Fatty (OLETF) rats are reported to be obese Type II (non-insulin-dependent) diabetic rats with insulin resistance and impaired…”
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Endothelin-1 induces cyclooxygenase-2 expression via nuclear factor of activated T-cell transcription factor in glomerular mesangial cells by SUGIMOTO, Toshiro, HANEDA, Masakazu, SAWANO, Hirotaka, ISSHIKI, Keiji, MAEDA, Shiro, KOYA, Daisuke, INOKI, Ken, YASUDA, Hitoshi, KASHIWAGI, Atsunori, KIKKAWA, Ryuichi

“…Nuclear factor of activated T cells (NFAT) originally was identified as a T-cell-specific transcription factor whose activity is regulated by calcineurin, one…”
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Impaired activation of glucose oxidation and NADPH supply in human endothelial cells exposed to H2O2 in high-glucose medium by Asahina, T., Kashiwagi, A., Nishio, Y., Ikebuchi, M., Harada, N., Tanaka, Y., Takagi, Y., Saeki, Y., Kikkawa, R., Shigeta, Y.

“…Impaired activation of glucose oxidation and NADPH supply in human endothelial cells exposed to H2O2 in high-glucose medium. T Asahina , A Kashiwagi , Y Nishio…”
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Stretch-induced overproduction of fibronectin in mesangial cells is mediated by the activation of mitogen-activated protein kinase by ISHIDA, T, HANEDA, M, MAEDA, S, KOYA, D, KIKKAWA, R

“…Stretch-induced overproduction of fibronectin in mesangial cells is mediated by the activation of mitogen-activated protein kinase. T Ishida , M Haneda , S…”
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Dinucleotide repeat polymorphism of matrix metalloproteinase-9 gene is associated with diabetic nephropathy by Maeda, Shiro, Haneda, Masakazu, Guo, Baoliang, Koya, Daisuke, Hayashi, Kazuyuki, Sugimoto, Toshiro, Isshiki, Keiji, Yasuda, Hitoshi, Kashiwagi, Atsunori, Kikkawa, Ryuichi

“…Dinucleotide repeat polymorphism of matrix metalloproteinase-9 gene is associated with diabetic nephropathy. Although genetic susceptibility has been proposed…”
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