Search Results - "KIKELJ, D"

Multitarget cardiovascular drugs by Trstenjak, U, Kikelj, D

“…Cardiovascular disease is the number one cause of death globally. Design of cardiovascular drugs based on new paradigms is therefore a prominent goal of…”
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Dual inhibitors of the blood coagulation enzymes by Kranjc, A, Kikelj, D

“…The search for an ideal anticoagulant has spanned decades and has resulted in several approaches and the identification of novel target molecules for…”
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Recent advances in the discovery of tissue factor/factor VIIa inhibitors and dual inhibitors of factor VIIa/factor Xa by Kranjc, A, Kikelj, D, Peterlin-Masic, L

“…The search for an ideal anticoagulant has spanned decades and has taken several approaches to the identification of novel target molecules for preventing and…”
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Influence of Chirality of the Preceding Acyl Moiety on the cis/trans Ratio of the Proline Peptide Bond by Breznik, Matej, Grdadolnik, Simona Golič, Giester, Gerald, Leban, Ivan, Kikelj, Danijel

“…We report that the cis/trans ratio of the proline peptide bond can be strongly influenced by the chirality of the acyl residue preceding proline. Acyl moieties…”
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Design and structure–activity relationship of thrombin inhibitors with an azaphenylalanine scaffold: potency and selectivity enhancements via P2 optimization by Zega, A, Mlinšek, G, Šepic, P, Golič Grdadolnik, S, Šolmajer, T, Tschopp, T.B, Steiner, B, Kikelj, D, Urleb, U

“…Theoretical and structural studies followed by the directed synthesis and in vitro biological tests lead us to novel noncovalent thrombin pseudopeptide…”
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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa by Cotman, Andrej Emanuel, Durcik, Martina, Benedetto Tiz, Davide, Fulgheri, Federica, Secci, Daniela, Sterle, Maša, Možina, Štefan, Skok, Žiga, Zidar, Nace, Zega, Anamarija, Ilaš, Janez, Peterlin Mašič, Lucija, Tomašič, Tihomir, Hughes, Diarmaid, Huseby, Douglas L., Cao, Sha, Garoff, Linnéa, Berruga Fernández, Talía, Giachou, Paraskevi, Crone, Lisa, Simoff, Ivailo, Svensson, Richard, Birnir, Bryndis, Korol, Sergiy V., Jin, Zhe, Vicente, Francisca, Ramos, Maria C., de la Cruz, Mercedes, Glinghammar, Björn, Lenhammar, Lena, Henderson, Sara R., Mundy, Julia E. A., Maxwell, Anthony, Stevenson, Clare E. M., Lawson, David M., Janssen, Guido V., Sterk, Geert Jan, Kikelj, Danijel

“…We have developed compounds with a promising activity against Acinetobacter baumannii and Pseudomonas aeruginosa, which are both on the WHO priority list of…”
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Recent advances in the synthesis of 2H-1,4-benzoxazin-3-(4H)-ones and 3,4-dihydro-2H-1,4-benzoxazines by Ilaš, Janez, Anderluh, Petra Štefanič, Dolenc, Marija Sollner, Kikelj, Danijel

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Arginine mimetics by Peterlin-Mašič, Lucija, Kikelj, Danijel

“…Arginine mimetics, which were designed and synthesised to mimic the function of the arginine moiety in numerous peptidomimetics, e.g. serine protease…”
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Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators by Zidar, Nace, Jakopin, Žiga, Madge, David J., Chan, Fiona, Tytgat, Jan, Peigneur, Steve, Dolenc, Marija Sollner, Tomašić, Tihomir, Ilaš, Janez, Mašič, Lucija Peterlin, Kikelj, Danijel

“…Voltage-gated sodium channels play an integral part in neurotransmission and their dysfunction is frequently a cause of various neurological disorders. On the…”
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Toward a Novel Class of Antithrombotic Compounds with Dual Function. Discovery of 1,4-Benzoxazin-3(4H)-one Derivatives Possessing Thrombin Inhibitory and Fibrinogen Receptor Antagonistic Activities by Štefanič Anderluh, Petra, Anderluh, Marko, Ilaš, Janez, Mravljak, Janez, Sollner Dolenc, Marija, Stegnar, Mojca, Kikelj, Danijel

“…A novel class of potential antithrombotic compounds with moderate thrombin inhibitory and fibrinogen receptor antagonistic activity is described. Combination…”
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Peptidomimetic thrombin inhibitors by Kikelj, Danijel

“…The central position of thrombin in the coagulation cascade has made it a popular target for discovery of novel antithrombotic agents. Starting with hirudin, a…”
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Design and synthesis of novel platelet fibrinogen receptor antagonists with 2H-1,4-benzoxazine-3(4H)-one scaffold. A systematic study by ANDERLUH, Marko, CESAR, Jozko, STEGNAR, Mojca, DOLENC, Marija Sollner, STEFANIC, Petra, KIKELJ, Danijel, JANES, Damjan, MURN, Jernej, NADRAH, Kristina, TOMINC, Mojca, ADDICKS, Elisabeth, GIANNIS, Athanassios

“…New platelet glycoprotein IIb/IIIa (GP IIb/IIIa, integrin alpha(IIb)beta3) antagonists were prepared on a 2H-1,4-benzoxazine-3(4H)-one scaffold. Their…”
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Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall by Gobec, Stanislav, Plantan, Ivan, Mravljak, Janez, Wilson, Rosalind A., Besra, Gurdyal S., Kikelj, Danijel

“…Graphic The first phosphonate inhibitors of antigen 85C––a major protein component of the Mycobacterium tuberculosis cell wall possessing mycolyltransferase…”
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Synthesis of alkyl 4-alkyl-2-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylates as peptidomimetic building blocks by Štefanič, Petra, Turnšek, Katja, Kikelj, Danijel

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Novel thrombin inhibitors incorporating non-basic partially saturated heterobicyclic P 1-Arginine mimetics by Peterlin-Mašic̆, Lucija, Mlinšek, Gregor, Šolmajer, Tomaž, Trampuš-Bakija, Alenka, Stegnar, Mojca, Kikelj, Danijel

“…The design, synthesis and biological activity of non-covalent thrombin inhibitors incorporating 4,5,6,7-tetrahydroindazole,…”
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Novel pyrazinone and pyridinone thrombin inhibitors incorporating weakly basic heterobicyclic P 1-arginine mimetics by Kranjc, Andreja, Mašič, Lucija Peterlin, Reven, Sebastjan, Mikic, Klemen, Preželj, Andrej, Stegnar, Mojca, Kikelj, Danijel

“…The design, synthesis and biological activity of new thrombin inhibitors with a pyridinone or pyrazinone core and different heterobicyclic P 1 arginine…”
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Novel thrombin inhibitors incorporating weakly basic heterobicyclic P 1-arginine mimetics: optimization via modification of P 1 and P 3 moieties by Kranjc, Andreja, Peterlin-Mašič, Lucija, Ilaš, Janez, Preželj, Andrej, Stegnar, Mojca, Kikelj, Danijel

“…The optimization of 3-amino-2-pyridinone acetamide thrombin inhibitors incorporating weakly basic heterobicyclic P 1-arginine side-chain mimetics is described…”
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A general synthetic approach to novel conformationally restricted arginine side chain mimetics by Peterlin-Mašič, Lucija, Jurca, Andreja, Marinko, Petra, Jančar, Anita, Kikelj, Danijel

“…A general synthesis of several novel partially saturated, conformationally restricted heterobicyclic arginine side chain mimetics is described. These compounds…”
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Selective 3-Amino-2-pyridinone acetamide thrombin inhibitors incorporating weakly basic partially saturated heterobicyclic P 1-Arginine mimetics by Peterlin-Mašič, Lucija, Kranjc, Andreja, Marinko, Petra, Mlinšek, Gregor, Šolmajer, Tomaž, Stegnar, Mojca, Kikelj, Danijel

“…Novel, highly selective and potent thrombin inhibitors were identified as a result of combing the 3-benzylsulfonylamino-2-pyridinone acetamide P 2–P 3…”
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A convenient synthesis of 4-aminomethyl-4,5,6,7-tetrahydro-1,3-benzothiazole arginine side-chain mimetics by Marinko, Petra, Kastelic, Jože, Krbavčič, Aleš, Kikelj, Danijel

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