Search Results - "KIELTY, Cay"

Fell‐Muir Lecture: Fibrillin microfibrils: structural tensometers of elastic tissues? by Kielty, Cay M.

“…Summary Fibrillin microfibrils are indispensable structural elements of connective tissues in multicellular organisms from early metazoans to humans. They have…”
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Elastic fibres in health and disease by Kielty, Cay M

“…Elastic fibres are a major class of extracellular matrix fibres that are abundant in dynamic connective tissues such as arteries, lungs, skin and ligaments…”
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Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro by Redondo-Castro, Elena, Cunningham, Catriona, Miller, Jonjo, Martuscelli, Licia, Aoulad-Ali, Sarah, Rothwell, Nancy J, Kielty, Cay M, Allan, Stuart M, Pinteaux, Emmanuel

“…Inflammation is a key contributor to central nervous system (CNS) injury such as stroke, and is a major target for therapeutic intervention. Effective…”
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Vascular endothelial growth factor can signal through platelet-derived growth factor receptors by Ball, Stephen G, Shuttleworth, C. Adrian, Kielty, Cay M

“…Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow-derived human adult…”
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Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions by Cain, Stuart A, McGovern, Amanda, Baldwin, Andrew K, Baldock, Clair, Kielty, Cay M

“…The extracellular glycoprotein fibrillin-1 forms microfibrils that act as the template for elastic fibers. Most mutations in fibrillin-1 cause Marfan syndrome…”
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ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions by Cain, Stuart A., Mularczyk, Ewa J., Singh, Mukti, Massam-Wu, Teresa, Kielty, Cay M.

“…ADAMTS10 and ADAMTS6 are homologous metalloproteinases with ill-defined roles. ADAMTS10 mutations cause Weill-Marchesani syndrome (WMS), implicating it in…”
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Elastic fibres in health and disease by Baldwin, Andrew K, Simpson, Andreja, Steer, Ruth, Cain, Stuart A, Kielty, Cay M

“…Elastic fibres are insoluble components of the extracellular matrix of dynamic connective tissues such as skin, arteries, lungs and ligaments. They are laid…”
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Independent multimerization of Latent TGFβ Binding Protein-1 stabilized by cross-linking and enhanced by heparan sulfate by Troilo, Helen, Steer, Ruth, Collins, Richard F., Kielty, Cay M., Baldock, Clair

“…TGFβ plays key roles in fibrosis and cancer progression, and latency is conferred by covalent linkage to latent TGFβ binding proteins (LTBPs). LTBP1 is…”
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Latent TGFβ complexes are transglutaminase cross-linked to fibrillin to facilitate TGFβ activation by Lockhart-Cairns, Michael P., Cain, Stuart A., Dajani, Rana, Steer, Ruth, Thomson, Jennifer, Alanazi, Yasmene F., Kielty, Cay M., Baldock, Clair

“…•TGFβ is regulated via the formation latent complexes in the extracellular matrix.•Fibrillin-1 is a substrate for transglutaminase-2 which forms a covalent…”
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ADAMTS10-mediated tissue disruption in Weill-Marchesani syndrome by Mularczyk, Ewa J, Singh, Mukti, Godwin, Alan R F, Galli, Francessco, Humphreys, Neil, Adamson, Antony D, Mironov, Aleksandr, Cain, Stuart A, Sengle, Gerhard, Boot-Handford, Ray P, Cossu, Giulio, Kielty, Cay M, Baldock, Clair

“…Abstract Fibrillin microfibrils are extracellular matrix assemblies that form the template for elastic fibres, endow blood vessels, skin and other elastic…”
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Inhibition of Platelet-Derived Growth Factor Receptor Signaling Regulates Oct4 and Nanog Expression, Cell Shape, and Mesenchymal Stem Cell Potency by Ball, Stephen G., Shuttleworth, Adrian, Kielty, Cay M.

“…Defining the signaling mechanisms that regulate the fate of adult stem cells is an essential step toward their use in regenerative medicine. Platelet‐derived…”
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Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation by Briggs, David C., Langford-Smith, Alexander W.W., Birchenough, Holly L., Jowitt, Thomas A., Kielty, Cay M., Enghild, Jan J., Baldock, Clair, Milner, Caroline M., Day, Anthony J.

“…Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two…”
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Assembly of fibrillin microfibrils governs extracellular deposition of latent TGFβ by Massam-Wu, Teresa, Chiu, Maybo, Choudhury, Rawshan, Chaudhry, Shazia S, Baldwin, Andrew K, McGovern, Amanda, Baldock, Clair, Shuttleworth, C. Adrian, Kielty, Cay M

“…Control of the bioavailability of the growth factor TGFβ is essential for tissue formation and homeostasis, yet precisely how latent TGFβ is incorporated into…”
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Fibrillin-1 regulates the bioavailability of TGFβ1 by Chaudhry, Shazia S, Cain, Stuart A, Morgan, Amanda, Dallas, Sarah L, Shuttleworth, C. Adrian, Kielty, Cay M

“…We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) β1, a…”
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Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells by Ball, Stephen G, Bayley, Christopher, Shuttleworth, C Adrian, Kielty, Cay M

“…Using human MSCs (mesenchymal stem cells) lacking VEGF (vascular endothelial growth factor) receptors, we show that the pro-angiogenic receptor neuropilin-1…”
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Mesenchymal stem cells and neovascularization: role of platelet‐derived growth factor receptors by Ball, Stephen G., Shuttleworth, C. Adrian, Kielty, Cay M.

“…•  Introduction •  The vascular endothelial growth factor/platelet‐derived growth factor super‐family of ligands and receptors ‐  Vascular endothelial growth…”
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Extracellular Matrix Molecule-Based Capture of Mesenchymal Stromal Cells Under Flow by Massam-Wu, Teresa, Cain, Stuart A, Kielty, Cay M

“…We present a method to capture mesenchymal stromal cells (MSCs) by adhesion to extracellular matrix (ECM) molecules under flow conditions. The technique…”
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Elastic fibres by Kielty, Cay M, Sherratt, Michael J, Shuttleworth, C Adrian

“…Elastic fibres are essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils. They endow…”
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Recombinant Extracellular Matrix Protein Fragments Support Human Embryonic Stem Cell Chondrogenesis by Cheng, Aixin, Cain, Stuart A, Tian, Pinyuan, Baldwin, Andrew K, Uppanan, Paweena, Kielty, Cay M, Kimber, Susan J

“…We previously developed a 14-day culture protocol under potentially GMP, chemically defined conditions, to generate chondroprogenitors from human embryonic…”
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Fibrillin-1 microfibril deposition is dependent on fibronectin assembly by Kinsey, Rachel, Williamson, Matthew R, Chaudhry, Shazia, Mellody, Kieran T, McGovern, Amanda, Takahashi, Seiichiro, Shuttleworth, C. Adrian, Kielty, Cay M

“…Newly deposited microfibrils strongly colocalise with fibronectin in primary fibroblasts. Microfibril formation is grossly inhibited by fibronectin depletion,…”
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