Search Results - "KIELTY, C. M"

The molecular genetics of Marfan syndrome and related disorders by Robinson, P N, Arteaga-Solis, E, Baldock, C, Collod-Béroud, G, Booms, P, De Paepe, A, Dietz, H C, Guo, G, Handford, P A, Judge, D P, Kielty, C M, Loeys, B, Milewicz, D M, Ney, A, Ramirez, F, Reinhardt, D P, Tiedemann, K, Whiteman, P, Godfrey, M

“…Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of connective tissue with prominent manifestations in the skeletal, ocular,…”
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Fibrillin microfibrils are reduced in skin exhibiting striae distensae by WATSON, R. E. B, PARRY, E. J, HUMPHRIES, J. D, JONES, C. J. P, POLSON, D. W, KIELTY, C. M, GRIFFITHS, C. E. M

“…Striae distensae (striae: stretch marks) are a common disfiguring condition associated with continuous and progressive stretching of the skin—as occurs during…”
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Fibrillin: from microfibril assembly to biomechanical function by Kielty, C. M., Baldock, C., Lee, D., Rock, M. J., Ashworth, J. L., Shuttleworth, C. A.

“…Fibrillins form the structural framework of a unique and essential class of extracellular microfibrils that endow dynamic connective tissues with long–range…”
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Fibrillin-Rich Microfibrils are Reduced in Photoaged Skin. Distribution at the Dermal–Epidermal Junction by Watson, Rachel E.B., Griffiths, Christopher E.M., Craven, Nicholas M., Shuttleworth, C. Adrian, Kielty, Cay M.

“…Chronic sun exposure results in photoaged skin with deep coarse wrinkles and loss of elasticity. We have examined the distribution and abundance of…”
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Mesenchymal Stromal Cells: Inhibiting PDGF Receptors or Depleting Fibronectin Induces Mesodermal Progenitors with Endothelial Potential by Ball, S. G., Worthington, J. J., Canfield, A. E., Merry, C. L. R., Kielty, C. M.

“…Realizing the full therapeutic potential of mesenchymal stromal/stem cells (MSCs) awaits improved understanding of mechanisms controlling their fate. Using…”
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Fibrillin and the eye by ASHWORTH, JANE L, KIELTY, CAY M, McLEOD, DAVID

“…Fibrillin polymers form the structural scaffold of extensible microfibrils 1-3 which are present in ocular elastic tissues and are arranged in parallel bundles…”
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Distribution and expression of type VI collagen in photoaged skin by Watson, R.E.B., Ball, S.G., Craven, N.M., Boorsma, J., East, C.L., Shuttleworth, C.A., Kielty, C.M., Griffiths, C.E.M.

“…Background Several of the characteristic clinical features of photoaged skin, including wrinkling, are thought to be dependent on changes in the dermal matrix…”
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Fibrillin-rich microfibrils: elastic biopolymers of the extracellular matrix by Kielty, C M, Wess, T J, Haston, L, Ashworth, Jane L, Sherratt, M J, Shuttleworth, C A

“…Fibrillin-rich microfibrils are evolutionarily ancient macromolecular assemblies of the extracellular matrix. They have unique extensible properties that endow…”
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Fibrillin-rich microfibrils of the extracellular matrix: ultrastructure and assembly by Sherratt, M.J., Wess, T.J., Baldock, C., Ashworth, J., Purslow, P.P., Shuttleworth, C.A., Kielty, C.M.

“…Fibrillin-rich microfibrils are a unique class of extensible connective tissue macromolecules. Their critical contribution to the establishment and maintenance…”
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Type VI Collagen Microfibrils: Evidence for a Structural Association with Hyaluronan by Kielty, Cay M., Whittaker, Stephen P., Grant, Michael E., Shuttleworth, C. Adrian

“…Type VI collagen, a widespread structural component of connective tissues, has been isolated in abundance from fetal bovine skin by a procedure involving…”
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Calcium Determines the Supramolecular Organization of Fibrillin-Rich Microfibrils by Wess, T. J., Purslow, P. P., Sherratt, M. J., Ashworth, J., Shuttleworth, C. A., Kielty, C. M.

“…Microfibrils are ubiquitous fibrillin-rich polymers that are thought to provide long-range elasticity to extracellular matrices, including the zonular…”
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Age-related changes in the temporal and spatial distributions of fibrillin and elastin mRNAS and proteins in acute cutaneous wounds of healthy humans by Ashcroft, Gillian S., Kielty, Cay M., Horan, Michael A., Ferguson, Mark W. J.

“…Elasticity and resilience of the skin are determined largely by the elastin framework, whose microfibrillar scaffold is composed of fibrillin. To date, the…”
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Clinical features of photodamaged human skin are associated with a reduction in collagen VII by CRAVEN, N.M., WATSON, R.E.B., JONES, C.J.P., SHUTTLEWORTH, C.A., KIELTY, C.M., GRIFFITHS, C.E.M.

“…Summary Chronically sun‐exposed or photodamaged human skin is characterized by a number of clinical features, including wrinkles. However, little is known…”
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Catabolism of intact type VI collagen microfibrils: susceptibility to degradation by serine proteinases by Kielty, C M, Lees, M, Shuttleworth, C A, Woolley, D

“…We present the first direct biochemical evidence for the turnover of intact type VI collagen microfibrils. Matrix-degrading enzymes of the serine proteinase…”
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Keratinocytes express fibrillin and assemble microfibrils: implications for dermal matrix organization by HAYNES, S.L., SHUTTLEWORTH, C.A., KIELTY, C.M.

“…Summary Fibrillin–containing microfibrils are key architectural structures of the upper dermis and integral components of the dermal elastic fibre network…”
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Three-dimensional reconstructions of extracellular matrix polymers using automated electron tomography by Baldock, C., Gilpin, C.J., Koster, A.J., Ziese, U., Kadler, K.E., Kielty, C.M., Holmes, D.F.

“…The extracellular matrix is an intricate network of macromolecules which provides support for cells and a framework for tissues. The detailed structure and…”
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Analyses of truncated fibrillin caused by a 366 bp deletion in the FBN1 gene resulting in Marfan syndrome by RAGHUNATH, M, KIELTY, C. M, KAINULAINEN, K, CHILD, A, PELTONEN, L, STEINMANN, B

“…We studied fibrillin synthesis in cultured fibroblasts from 11 members of a three-generation family with Marfan syndrome, caused by a large in-frame deletion…”
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The supramolecular organisation of fibrillin-rich microfibrils determines the mechanical properties of bovine zonular filaments by Wright, D M, Duance, V C, Wess, T J, Kielty, C M, Purslow, P P

“…The zonular filaments from the eyes of cows are rich in microfibrils containing fibrillin. Tensile tests, stress-relaxation tests and X-ray diffraction studies…”
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A novel hyaluronan-based biomaterial (Hyaff-11 ®) as a scaffold for endothelial cells in tissue engineered vascular grafts by Turner, Neill J., Kielty, Cay M., Walker, Michael G., Canfield, Ann E.

“…Current prosthetic small diameter vascular grafts show poor long-term patency rates, leading to the pursuit of a biological alternative. Hyaff-11 is a…”
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Microfibrillar elements in the synovial joint: presence of type VI collagen and fibrillin-containing microfibrils by Waggett, A D, Kielty, C M, Shuttleworth, C A

“…OBJECTIVES--The aims were to isolate and positively identify the microfibrillar elements which have been observed in the synovial lining. In addition, synovial…”
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