Search Results - "KIEFL, Rosemarie"

Systemic inflammation and pro-inflammatory cytokine profile predict response to checkpoint inhibitor treatment in NSCLC: a prospective study by Kauffmann-Guerrero, Diego, Kahnert, Kathrin, Kiefl, Rosemarie, Sellmer, Laura, Walter, Julia, Behr, Jürgen, Tufman, Amanda

“…Treatment with single agent immune checkpoint inhibitors (ICIs) has tremendously changed second line therapy in NSCLC. However, there are still no reliable…”
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Interactions among Lung Cancer Cells, Fibroblasts, and Macrophages in 3D Co-Cultures and the Impact on MMP-1 and VEGF Expression by Liu, Xiao-Qing, Kiefl, Rosemarie, Roskopf, Claudia, Tian, Fei, Huber, Rudolf M

“…In vitro cell-based models of lung cancer are frequently employed to study invasion and the mechanisms behind metastasis. However, these models often study…”
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Consequences of the COVID-19 pandemic on lung cancer care and patient health in a German lung cancer center: results from a cross-sectional questionnaire by Walter, Julia, Sellmer, Laura, Kahnert, Kathrin, Kiefl, Rosemarie, Syunyaeva, Zulfiya, Kauffmann-Guerrero, Diego, Manapov, Farkhad, Schneider, Christian, Behr, Juergen, Tufman, Amanda

“…The novel coronavirus SARS-CoV-2 has caused a global COVID-19 pandemic, leading to worldwide changes in public health measures. In addition to changes in the…”
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Markers of Immune Cell Exhaustion as Predictor of Survival in Surgically-Treated Early-Stage NSCLC by Sellmer, Laura, Kovács, Julia, Walter, Julia, Kumbrink, Jörg, Neumann, Jens, Kauffmann-Guerrero, Diego, Kiefl, Rosemarie, Schneider, Christian, Jung, Andreas, Behr, Jürgen, Tufman, Amanda

“…Background Tumor tissue as well as regional lymph nodes are removed during curative surgery for early-stage non-small cell lung cancer (NSCLC). These tissues…”
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Response to high-altitude triggers in seasonal asthmatics on and off inhaled corticosteroid treatment by Mertsch, Pontus, Götschke, Jeremias, Walter, Julia, Mümmler, Carlo, Ghiani, Alessandro, Schürmann, Ulrike, Kiefl, Rosemarie, Maria Huber, Rudolf, Behr, Jürgen, Kneidinger, Nikolaus, Milger, Katrin

“…Due to the effects of climate change, winter sport enthusiasts will be increasingly forced to stay at higher altitudes. High altitude (HA) environmental…”
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Combined use of toll-like receptor agonists and prostaglandin E2 in the FastDC model : Rapid generation of human monocyte-derived dendritic cells capable of migration and IL-12p70 production by DAUER, Marc, LAM, Veronique, ARNOLD, Hannah, JUNKMANN, Jana, KIEFL, Rosemarie, BAUER, Christian, SCHNURR, Max, ENDRES, Stefan, EIGLER, Andreas

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IFN-α promotes definitive maturation of dendritic cells generated by short-term culture of monocytes with GM-CSF and IL-4 by Dauer, Marc, Schad, Katharina, Junkmann, Jana, Bauer, Christian, Herten, Jan, Kiefl, Rosemarie, Schnurr, Max, Endres, Stefan, Eigler, Andreas

“…Dendritic cells (DC) generated in vitro have to be viable and phenotypically mature to be capable of inducing T cell‐mediated immunity after in vivo…”
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Trans-fatty acid levels in erythrocytes in Europe by von Schacky, Clemens, Passow, Adrian, Kiefl, Rosemarie

“…Purpose High, but not low levels of trans-fatty acids (TFA) in erythrocytes are associated with increased mortality. Current erythrocyte TFA levels in Europe…”
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Hedgehog Pathway Activation Might Mediate Pemetrexed Resistance in NSCLC Cells by Liu, Yichao, Huber, Rudolf M, Kiefl, Rosemarie, Tufman, Amanda, Kauffmann-Guerrero, Diego

“…Resistance to chemotherapeutic agents is the main cause of reduced survival in non-small cell lung cancer (NSCLC) patients. The Hedgehog (HH) pathway has been…”
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Role of the erythropoietin receptor in Lung Cancer cells: erythropoietin exhibits angiogenic potential by Liu, Xiaoqing, Tufman, Amanda, Behr, Juergen, Kiefl, Rosemarie, Goldmann, Torsten, Huber, Rudolf M.

“…Background: Recombinant human erythropoietin (rHuEPO), a hormone regulating the proliferation and differentiation of erythroid cells, is one of the…”
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Concomitant gemcitabine therapy negatively affects DC vaccine-induced CD8+ T-cell and B-cell responses but improves clinical efficacy in a murine pancreatic carcinoma model by Bauer, Christian, Sterzik, Alexander, Bauernfeind, Franz, Duewell, Peter, Conrad, Claudius, Kiefl, Rosemarie, Endres, Stefan, Eigler, Andreas, Schnurr, Max, Dauer, Marc

“…Background Multiple studies have shown that dendritic cell (DC)-based vaccines can induce antitumor immunity. Previously, we reported that gemcitabine enhances…”
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The omega-3 index in patients with heart failure: A prospective cohort study by Berliner, Dominik, Mattern, Sarah, Wellige, Mareike, Malsch, Carolin, Güder, Gülmisal, Brenner, Susanne, Morbach, Caroline, Deubner, Nikolas, Breunig, Margret, Kiefl, Rosemarie, Angermann, Christiane E., Ertl, Georg, von Schacky, Clemens, Störk, Stefan

“…•In patients hospitalized for decompensated heart failure, marked depletion of omega-3 fatty acids was detected.•Although the Omega-3 index was associated with…”
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Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases by Tufman, Amanda, Huber, Rudolf Maria, Völk, Stefanie, Aigner, Frederic, Edelmann, Martin, Gamarra, Fernando, Kiefl, Rosemarie, Kahnert, Kathrin, Tian, Fei, Boulesteix, Anne-Laure, Endres, Stefan, Kobold, Sebastian

“…Interleukin-22 (IL-22) is involved in lung diseases such as pneumonia, asthma and lung cancer. Lavage mirrors the local environment, and may provide insights…”
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The Hedgehog Pathway Inhibitor GDC-0449 Alters the Expression Level of the Pathway Components In Lung Cancer Cell Lines by Tian, Fei, PhD, Kiefl, Rosemarie, Tufman, Amanda, MD, Huber, Rudolf, MD

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The Hedgehog Pathway Inhibitor GDC-0449 Alters Intracellular Ca2+ Homeostasis and Inhibits Cell Growth in Cisplatin-resistant Lung Cancer Cells by TIAN, Fei, SCHRODL, Kathrin, KIEFL, Rosemarie, MARIA HUBER, Rudolf, BERGNER, Albrecht

“…Cisplatin resistance is an important issue in lung cancer. We aimed at investigating if the Hedgehog pathway inhibitor GDC-0449 is effective in…”
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Dendritic cell-based vaccination of patients with advanced pancreatic carcinoma: results of a pilot study by Bauer, Christian, Dauer, Marc, Saraj, Samira, Schnurr, Maximilian, Bauernfeind, Franz, Sterzik, Alexander, Junkmann, Jana, Jakl, Veronika, Kiefl, Rosemarie, Oduncu, Fuat, Emmerich, Bertold, Mayr, Doris, Mussack, Thomas, Bruns, Christiane, Rüttinger, Dominik, Conrad, Claudius, Jauch, Karl-Walter, Endres, Stefan, Eigler, Andreas

“…Background and aims Dendritic cell (DC)-based vaccination can induce antitumor T cell responses in vivo. This clinical pilot study examined feasibility and…”
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Abstract 3360: The hedgehog pathway inhibitor GDC-0449 alters intracellular Ca2+-homeostasis and inhibits cell growth in cisplatin-resistant lung cancer cells by Tian, Fei, Huber, Rudolf Maria, Schrödl, Kathrin, Tufman, Amanda, Kiefl, Rosemarie, Bergner, Albrecht

“…Abstract Cisplatin-resistance is an important issue in lung cancer. The hedgehog signaling pathway (Hh) has been shown to be activated in cancer. GDC-0449 is a…”
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Concomitant gemcitabine therapy negatively affects DC vaccine-induced CD8^sup +^ T-cell and B-cell responses but improves clinical efficacy in a murine pancreatic carcinoma model by Bauer, Christian, Sterzik, Alexander, Bauernfeind, Franz, Duewell, Peter, Conrad, Claudius, Kiefl, Rosemarie, Endres, Stefan, Eigler, Andreas, Schnurr, Max, Dauer, Marc

“…Multiple studies have shown that dendritic cell (DC)-based vaccines can induce antitumor immunity. Previously, we reported that gemcitabine enhances the…”
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Concomitant gemcitabine therapy negatively affects DC vaccine-induced CD8 super(+) T-cell and B-cell responses but improves clinical efficacy in a murine pancreatic carcinoma model by Bauer, Christian, Sterzik, Alexander, Bauernfeind, Franz, Duewell, Peter, Conrad, Claudius, Kiefl, Rosemarie, Endres, Stefan, Eigler, Andreas, Schnurr, Max, Dauer, Marc

“…Background: Multiple studies have shown that dendritic cell (DC)-based vaccines can induce antitumor immunity. Previously, we reported that gemcitabine…”
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FastDC derived from human monocytes within 48 h effectively prime tumor antigen-specific cytotoxic T cells by Dauer, Marc, Schad, Katharina, Herten, Jan, Junkmann, Jana, Bauer, Christian, Kiefl, Rosemarie, Endres, Stefan, Eigler, Andreas

“…Previously, we have shown that dendritic cells (DCs) with full T-cell stimulatory capacity can be derived from human monocytes after 48 h of in vitro culture (…”
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