Search Results - "KIDACHI, Yumi"

6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) from Wasabia japonica alleviates inflammatory bowel disease (IBD) by potential inhibition of glycogen synthase kinase 3 beta (GSK-3β) by Lohning, Anna, Kidachi, Yumi, Kamiie, Katsuyoshi, Sasaki, Kazuo, Ryoyama, Kazuo, Yamaguchi, Hideaki

“…Inflammatory bowel disease (IBD) describes a set of disorders involving alterations to gastrointestinal physiology and mucosal immunity. Unravelling its…”
Get full text

Larval mesenchyme cell specification in the primitive echinoid occurs independently of the double-negative gate by Yamazaki, Atsuko, Kidachi, Yumi, Yamaguchi, Masaaki, Minokawa, Takuya

“…Echinoids (sea urchins) are divided into two major groups - cidaroids (a 'primitive' group) and euechinoids (a 'derived' group). The cidaroids are a promising…”
Get full text

Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: Induction of actin disruption and tumor cell-selective toxicity by Yamaguchi, Hideaki, Noshita, Toshiro, Yu, Tao, Kidachi, Yumi, Kamiie, Katsuyoshi, Umetsu, Hironori, Ryoyama, Kazuo

“…Licorice extracts are used worldwide in foods and medicines, and glycyrrhetinic acid (GA) is a licorice component that has been reported to induce various…”
Get full text

“Micromere” formation and expression of endomesoderm regulatory genes during embryogenesis of the primitive echinoid Prionocidaris baculosa by Yamazaki, Atsuko, Kidachi, Yumi, Minokawa, Takuya

“…Blastomere composition and expression profiles of wnt8 and hox11/13b orthologues were examined in the primitive indirect‐developing echinoid Prionocidaris…”
Get full text

Glycyrrhetinic Acid Induces Anoikis-Like Death and Cytoskeletal Disruption in the Central Nervous System Tumorigenic Cells by Yamaguchi, Hideaki, Kidachi, Yumi, Kamiie, Katsuyoshi, Noshita, Toshiro, Umetsu, Hironori, Ryoyama, Kazuo

“…We analyzed the effects of glycyrrhetinic acid (GA), a licorice compound, on the induction of anoikis-like death and cytoskeletal disruption in the central…”
Get full text

New cytotoxic phenolic derivatives from matured fruits of Magnolia denudata by Noshita, T.(Aomori Univ. (Japan)), Kiyota, H, Kidachi, Y, Ryoyama, K, Funayama, S, Hanada, K, Murayama, T

“…Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans,…”
Get full text

Isolation of Ursolic Acid from Apple Peels and Its Specific Efficacy as a Potent Antitumor Agent by Yamaguchi, Hideaki, Noshita, Toshiro, Kidachi, Yumi, Umetsu, Hironori, Hayashi, Masahiko, Komiyama, Kanki, Funayama, Shinji, Ryoyama, Kazuo

“…Dried apple peels were extracted with n-hexane, chloroform, and methanol successively. The portion of the chloroform extract that showed the strongest…”
Get full text

Anti-Tumor Activity of an Enzymatically Synthesized α-1,6 Branched α-1,4-Glucan, Glycogen by RYOYAMA, Kazuo, KIDACHI, Yumi, YAMAGUCHI, Hideaki, KAJIURA, Hideki, TAKATA, Hiroki

“…Oral administration of an enzymatically synthesized α-1,4:1,6-glycogen (ESG) at a dose of 50 μg/ml significantly prolonged the survival time of Meth A…”
Get full text

Differentiation of Serum-Free Mouse Embryo Cells into an Astrocytic Lineage is Associated with the Asymmetric Production of Early Neural, Neuronal and Glial Markers by Yamaguchi, Hideaki, Kidachi, Yumi, Umetsu, Hironori, Ryoyama, Kazuo

“…Serum-free mouse embryo (SFME) cells, the astrocyte progenitor cells in the central nervous system (CNS), were exposed to 10 ng/ml leukemia inhibitory factor…”
Get full text

Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation by Yamaguchi, Hideaki, Zhu, Jun, Yu, Tao, Sasaki, Kazuo, Umetsu, Hironori, Kidachi, Yumi, Ryoyama, Kazuo

“…The effects of bisphenol A (BPA) on the differentiation of serum-free mouse embryo (SFME) cells, the astrocyte progenitor cells in the central nervous system,…”
Get full text

Machilin G and four neolignans from young fruits of Magnolia denudata show various degrees of inhibitory activity on nitric oxide (NO) production by Noshita, T.(Aomori Univ. (Japan)), Funayama, S, Hirakawa, T, Kidachi, Y, Ryoyama, K

“…Denudatin A and B, denudadione B, fargesone A and machilin G were isolated from Magnolia denudata. These compounds showed inhibitory effects on nitric oxide…”
Get full text

The augmenting activity of 6-(Methylsulfinyl)hexyl isothiocyanate on cellular glutathione levels is less sensitive to thiol compounds than its cytotoxic activity by Kidachi, Y.(Aomori Univ. (Japan)), Noshita, T, Yamaguchi, H, Umetsu, H, Fuke, Y, Ryoyama, K

“…We analyzed the effects of thiol compounds on the biological activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC). Thiol compounds abolished the…”
Get full text

Detection of 6-(Methylsulfinyl)hexyl Isothiocyanate (6-MITC) and Its Conjugate with N-Acetyl-L-cysteine (NAC) by High Performance Liquid Chromatograpy-Atmospheric Pressure Chemical Ionization Mass Spectrometry (HPLC-MS/APCI) by Yamaguchi, Hideaki, Noshita, Toshiro, Kidachi, Yumi, Umetsu, Hironori, Fuke, Yoko, Ryoyama, Kazuo

“…A method using high-performance liquid chromatography (HPLC) and atmospheric pressure chemical ionization (APCI) mass spectrometry (MS) was established for the…”
Get full text

Mouse 11β-Hydroxysteroid Dehydrogenase Type 2 for Human Application: Homology Modeling, Structural Analysis and Ligand-Receptor Interaction by Yamaguchi, Hideaki, Akitaya, Tatsuo, Kidachi, Yumi, Kamiie, Katsuyoshi, Noshita, Toshiro, Umetsu, Hironori, Ryoyama, Kazuo

“…Mouse (m) 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) was homology-modeled, and its structure and ligand-receptor interaction were analyzed. The modeled…”
Get full text

Differentiation of Serum-Free Mouse Embryo Cells into an Astrocytic Lineage is Associated with the Asymmetric Production of Early Neural, Neuronal and Glial Markers by Hideaki YAMAGUCHIa, Yumi KIDACHIa, Hironori UMETSUb, Kazuo RYOYAMAa

“…Serum-free mouse embryo (SFME) cells, the astrocyte progenitor cells in the central nervous system (CNS), were exposed to 10ng/ml leukemia inhibitory factor…”
Get full text

Detection of 6-(Methylsulfinyl)hexyl Isothiocyanate(6-MITC) and Its Conjugate with N-Acetyl-L-cysteine(NAC) by High Performance Liquid Chromatograpy-Atmospheric Pressure Chemical Ionization Mass Spectrometry(HPLC-MS/APCI) by Hideaki YAMAGUCHIa, Toshiro NOSHITAa, Yumi KIDACHIa, Hironori UMETSUb, Yoko FUKEc, Kazuo RYOYAMAa

“…A method using high-performance liquid chromatography (HPLC)and atmospheric pressure chemical ionization (APCI) mass spectrometry (MS) was established for the…”
Get full text

Utilization of 6-(methylsulfinyl)hexyl isothiocyanate for sensitization of tumor cells to antitumor agents in combination therapies by Yamaguchi, Hideaki, Kidachi, Yumi, Kamiie, Katsuyoshi, Noshita, Toshiro, Umetsu, Hironori, Fuke, Yoko, Ryoyama, Kazuo

“…In the present study, we performed in silico and in vitro analyses to evaluate the chemosensitizing effects of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC)…”
Get full text

Intracellular accumulation of structurally varied isothiocyanates correlates with inhibition of nitric oxide production in proinflammatory stimuli-activated tumorigenic macrophage-like cells by Yamaguchi, Hideaki, Kamiie, Katsuyoshi, Kidachi, Yumi, Noshita, Toshiro, Umetsu, Hironori, Fuke, Yoko, Ryoyama, Kazuo

“…In the present study, we analyzed the intracellular accumulation of 6-(methylsulfinyl)hexyl isothiocyanate (6MITC) and its analogs in proinflammatory…”
Get full text

Selective cytotoxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells: Potential involvement of H-Ras downregulation by Yu, Tao, Yamaguchi, Hideaki, Noshita, Toshiro, Kidachi, Yumi, Umetsu, Hironori, Ryoyama, Kazuo

“…With the intensive need for the development of more effective and safer agents for chemoprevention and therapy of human cancer, natural products from plants…”
Get full text

Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity by Noshita, Toshiro, Kidachi, Yumi, Funayama, Hirokazu, Kiyota, Hiromasa, Yamaguchi, Hideaki, Ryoyama, Kazuo

“…There is increasing demand for novel anti-inflammatory drugs with different mechanisms of action. We synthesized a series of isothiocyanates 2b– h based on…”
Get full text