Search Results - "KIAN ANG"

Tobacco Smoking and Increased Risk of Death and Progression for Patients With p16-Positive and p16-Negative Oropharyngeal Cancer by GILLISON, Maura L, QIANG ZHANG, JORDAN, Richard, WEIHONG XIAO, WESTRA, William H, TROTTI, Andy, SPENCER, Sharon, HARRIS, Jonathan, CHUNG, Christine H, KIAN ANG, K

“…Tobacco smoking is associated with oropharynx cancer survival, but to what extent cancer progression or death increases with increasing tobacco exposure is…”
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Factors Associated With Severe Late Toxicity After Concurrent Chemoradiation for Locally Advanced Head and Neck Cancer: An RTOG Analysis by MACHTAY, Mitchell, MOUGHAN, Jennifer, TROTTI, Andrew, GARDEN, Adam S, WEBER, Randal S, COOPER, Jay S, FORASTIERE, Arlene, KIAN ANG, K

“…Concurrent chemoradiotherapy (CCRT) for squamous cell carcinoma of the head and neck (SCCHN) increases both local tumor control and toxicity. This study…”
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Long-term Follow-up of the RTOG 9501/Intergroup Phase III Trial: Postoperative Concurrent Radiation Therapy and Chemotherapy in High-Risk Squamous Cell Carcinoma of the Head and Neck by Cooper, Jay S., MD, Zhang, Qiang, PhD, Pajak, Thomas F., PhD, Forastiere, Arlene A., MD, Jacobs, John, MD, Saxman, Scott B., MD, Kish, Julie A., MD, Kim, Harold E., MD, Cmelak, Anthony J., MD, Rotman, Marvin, MD, Lustig, Robert, MD, Ensley, John F., MD, Thorstad, Wade, MD, Schultz, Christopher J., MD, Yom, Sue S., MD, Ang, K. Kian, MD, PhD

“…Purpose Previous analysis of this Intergroup trial demonstrated that with a median follow-up among surviving patients of 45.9 months, the concurrent…”
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Intensity-Modulated Radiation Therapy With or Without Chemotherapy for Nasopharyngeal Carcinoma: Radiation Therapy Oncology Group Phase II Trial 0225 by LEE, Nancy, HARRIS, Jonathan, JONES, Christopher, KIAN ANG, K, GARDEN, Adam S, STRAUBE, William, GLISSON, Bonnie, PING XIA, BOSCH, Walter, MORRISON, William H, QUIVEY, Jeanne, THORSTAD, Wade

“…To investigate the feasibility of intensity-modulated radiation therapy (IMRT) with or without chemotherapy, and to assess toxicities, failure patterns, and…”
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Final Results of Local-Regional Control and Late Toxicity of RTOG 9003: A Randomized Trial of Altered Fractionation Radiation for Locally Advanced Head and Neck Cancer by Beitler, Jonathan J., MD, MBA, Zhang, Qiang, PhD, Fu, Karen K., MD, Trotti, Andy, MD, Spencer, Sharon A., MD, Jones, Christopher U., MD, Garden, Adam S., MD, Shenouda, George, MD, Harris, Jonathan, MS, Ang, Kian K., MD, PhD (deceased)

“…Purpose To test whether altered radiation fractionation schemes (hyperfractionation [HFX], accelerated fractionation, continuous [AFX-C], and accelerated…”
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Association of Human Papillomavirus and p16 Status With Outcomes in the IMCL-9815 Phase III Registration Trial for Patients With Locoregionally Advanced Oropharyngeal Squamous Cell Carcinoma of the Head and Neck Treated With Radiotherapy With or Without Cetuximab by Rosenthal, David I, Harari, Paul M, Giralt, Jordi, Bell, Diana, Raben, David, Liu, Joyce, Schulten, Jeltje, Ang, Kian K, Bonner, James A

“…We conducted a retrospective evaluation of the IMCL-9815 study to examine the association of human papillomavirus (HPV) and p16 protein expression status with…”
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Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer by Ang, K. Kian, Harris, Jonathan, Wheeler, Richard, Weber, Randal, Rosenthal, David I, Nguyen-Tân, Phuc Felix, Westra, William H, Chung, Christine H, Jordan, Richard C, Lu, Charles, Kim, Harold, Axelrod, Rita, Silverman, C. Craig, Redmond, Kevin P, Gillison, Maura L

“…Human papillomavirus (HPV)–associated oropharyngeal squamous-cell carcinoma differs from oropharyngeal cancers caused by tobacco and other factors. In this…”
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TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence by SKINNER, Heath D, SANDULACHE, Vlad C, OW, Thomas J, MEYN, Raymond E, YORDY, John S, BEADLE, Beth M, FITZGERALD, Alison L, GIRI, Uma, KIAN ANG, K, MYERS, Jeffrey N

“…Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is primarily driven by tumor cell radioresistance leading to locoregional recurrence…”
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Adaptive radiotherapy for head and neck cancer—Dosimetric results from a prospective clinical trial by Schwartz, David L, Garden, Adam S, Shah, Shalin J, Chronowski, Gregory, Sejpal, Samir, Rosenthal, David I, Chen, Yipei, Zhang, Yongbin, Zhang, Lifei, Wong, Pei-Fong, Garcia, John A, Kian Ang, K, Dong, Lei

“…Abstract Purpose To conduct a clinical trial evaluating adaptive head and neck radiotherapy (ART). Methods Patients with locally advanced oropharyngeal cancer…”
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ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1 by Zhang, Peijing, Wei, Yongkun, Wang, Li, Debeb, Bisrat G., Yuan, Yuan, Zhang, Jinsong, Yuan, Jingsong, Wang, Min, Chen, Dahu, Sun, Yutong, Woodward, Wendy A., Liu, Yongqing, Dean, Douglas C., Liang, Han, Hu, Ye, Ang, K. Kian, Hung, Mien-Chie, Chen, Junjie, Ma, Li

“…Epithelial–mesenchymal transition (EMT) is associated with characteristics of breast cancer stem cells, including chemoresistance and radioresistance. However,…”
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An Epithelial―Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance by AVERETT BYERS, Lauren, LIXIA DIAO, NILSSON, Monique B, GUDIKOTE, Jayanthi, TRAN, Hai, CARDNELL, Robert J. G, BEARSS, David J, WARNER, Steven L, FOULKS, Jason M, KANNER, Steven B, GANDHI, Varsha, KRETT, Nancy, JING WANG, ROSEN, Steven T, KIM, Edward S, HERBST, RoyS, BLUMENSCHEIN, George R, LEE, J. Jack, LIPPMAN, Scott M, KIAN ANG, K, MILLS, Gordon B, HONG, Waun K, WEINSTEIN, John N, SAINTIGNY, Pierre, WISTUBA, Ignacio I, COOMBES, Kevin R, MINNA, John D, HEYMACH, John V, GIRARD, Luc, PEYTON, Michael, LI SHEN, YOUHONG FAN, GIRI, Uma, TUMULA, Praveen K

“…Epithelial-mesenchymal transition (EMT) has been associated with metastatic spread and EGF receptor (EGFR) inhibitor resistance. We developed and validated a…”
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Human Papillomavirus as a Marker of the Natural History and Response to Therapy of Head and Neck Squamous Cell Carcinoma by Ang, Kie Kian, MD, PhD, Sturgis, Erich M., MD

“…There has been a gradual change in the demographics of head and neck carcinoma. Although relatively uncommon, the incidence of oropharyngeal carcinoma has been…”
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Delineation of the neck node levels for head and neck tumors: A 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines by Grégoire, Vincent, Ang, Kian, Budach, Wilfried, Grau, Cai, Hamoir, Marc, Langendijk, Johannes A, Lee, Anne, Le, Quynh-Thu, Maingon, Philippe, Nutting, Chris, O’Sullivan, Brian, Porceddu, Sandro V, Lengele, Benoit

“…Abstract In 2003, a panel of experts published a set of consensus guidelines for the delineation of the neck node levels in node negative patients (Radiother…”
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Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck by Bonner, James A, Harari, Paul M, Giralt, Jordi, Azarnia, Nozar, Shin, Dong M, Cohen, Roger B, Jones, Christopher U, Sur, Ranjan, Raben, David, Jassem, Jacek, Ove, Roger, Kies, Merrill S, Baselga, Jose, Youssoufian, Hagop, Amellal, Nadia, Rowinsky, Eric K, Ang, K. Kian

“…Treatment of advanced locoregional head and neck cancer with high-dose radiotherapy plus cetuximab was superior to radiotherapy alone in improving local…”
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Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial by Lee, Nancy Y, Dr, Zhang, Qiang, PhD, Pfister, David G, Prof, Kim, John, MD, Garden, Adam S, Prof, Mechalakos, James, PhD, Hu, Kenneth, MD, Le, Quynh T, MD, Colevas, A Dimitrios, MD, Glisson, Bonnie S, MD, Chan, Anthony TC, Prof, Ang, K Kian, Prof

“…Summary Background We aimed to improve the outcomes for locoregionally advanced nasopharyngeal carcinoma by testing the feasibility and safety of the addition…”
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Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis by Lacas, Benjamin, Bourhis, Jean, Overgaard, Jens, Zhang, Qiang, Grégoire, Vincent, Nankivell, Matthew, Zackrisson, Björn, Szutkowski, Zbigniew, Suwiński, Rafał, Poulsen, Michael, O'Sullivan, Brian, Corvò, Renzo, Laskar, Sarbani Ghosh, Fallai, Carlo, Yamazaki, Hideya, Dobrowsky, Werner, Cho, Kwan Ho, Beadle, Beth, Langendijk, Johannes A, Viegas, Celia Maria Pais, Hay, John, Lotayef, Mohamed, Parmar, Mahesh K B, van Herpen, Carla, Maingon, Philippe, Trotti, Andy M, Grau, Cai, Pignon, Jean-Pierre, Blanchard, Pierre, Blanchard, Pierre, Bourhis, Jean, Lacas, Benjamin, Pignon, Jean Pierre, Bernier, Jacques, Le, Quynh-Thu, Overgaard, Jens, Parmar, Masheh KB, Agarwal, Jai Prakash, Aupérin, Anne, Ang, Kian K, Awwad, Hassan K, Bartelink, Harry, Benhamou, Ellen, Budach, Wilfried, Chitapanarux, Imjai, Cho, Kwan Ho, Collette, Laurence, Corvò, Renzo, Dani, Carla, Dische, Stanley, Dobrowsky, Werner, Denham, James W, Driessen, Chantal ML, Fallai, Carlo, Beadle, Beth, Laskar, Sarbani Ghosh, Ghoshal, Sushmita, Grau, Cai, Gregoire, Vincent, Hay, John H, van Herpen, Carla, Hliniak, Andrzej, Johansen, Jørgen, Kristiansen, Claus Andrup, Krstevska, Valentina, Langendijk, Johannes A., Lapeyre, Michel, Lotayef, Mohamed, Maciejewski, Boguslaw, Maingon, Philippe, Michalski, Wojciech, Moon, Sung Ho, Nankivell, Matthew, Nishiyama, Kinji, O'Sullivan, Brian, Parmar, Mahesh KB, Pignon, Jean-Pierre, Poulsen, Michael G, Ramadas, Kunnambath, Rishi, Anupam, Rosenthal, David I., Sanguineti, Giuseppe, Saunders, Michele I, Sire, Christian, Skladowski, Krzysztof, Souhami, Luis, Suwinski, Rafal, Szutkowski, Zbigniew, Tandon, Nitin, van Tinteren, Harm, Torri, Valter, Tripcony, Lee, Viegas, Celia Maria Pais, Waldron, John, Widder, Joachim, Wong, Stuart, Wu, Jonn S, Yamazaki, Hideya, Zackrisson, Björn, Zhang, Qiang

“…The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with…”
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Multi-Institutional Trial of Accelerated Hypofractionated Intensity-Modulated Radiation Therapy for Early-Stage Oropharyngeal Cancer (RTOG 00-22) by Eisbruch, Avraham, M.D, Harris, Jonathan, M.S, Garden, Adam S., M.D, Chao, Clifford K.S., M.D, Straube, William, Ph.D, Harari, Paul M., M.D, Sanguineti, Giuseppe, M.D, Jones, Christopher U., M.D, Bosch, Walter R., D.Sc, Ang, K. Kian, M.D., Ph.D

“…Purpose To assess the results of a multi-institutional study of intensity-modulated radiation therapy (IMRT) for early oropharyngeal cancer. Patients and…”
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Larynx preservation clinical trial design: Key issues and recommendations-A consensus panel summary by Lefebvre, Jean-Louis, Ang, K. Kian

“…Background To develop guidelines for the conduct of phase III clinical trials of larynx preservation in patients with locally advanced laryngeal and…”
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Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes by Keck, Michaela K, Zuo, Zhixiang, Khattri, Arun, Stricker, Thomas P, Brown, Christopher D, Imanguli, Matin, Rieke, Damian, Endhardt, Katharina, Fang, Petra, Brägelmann, Johannes, DeBoer, Rebecca, El-Dinali, Mohamed, Aktolga, Serdal, Lei, Zhengdeng, Tan, Patrick, Rozen, Steve G, Salgia, Ravi, Weichselbaum, Ralph R, Lingen, Mark W, Story, Michael D, Ang, K Kian, Cohen, Ezra E W, White, Kevin P, Vokes, Everett E, Seiwert, Tanguy Y

“…Current classification of head and neck squamous cell carcinomas (HNSCC) based on anatomic site and stage fails to capture biologic heterogeneity or adequately…”
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Larynx Preservation Clinical Trial Design: Key Issues and Recommendations—A Consensus Panel Summary by Lefebvre, Jean-Louis, M.D, Ang, K. Kian, M.D

“…Purpose To develop guidelines for the conduct of Phase III clinical trials of larynx preservation in patients with locally advanced laryngeal and…”
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