Search Results - "KHARITONOV, Sergei A"

Exhaled biomarkers by Kharitonov, Sergei A, Barnes, Peter J

“…Assessing airway and lung inflammation is important for investigating the underlying mechanisms of asthma and COPD. Yet these cannot be measured directly in…”
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A Novel Approach to Partition Central and Peripheral Airway Nitric Oxide by Paredi, Paolo, MD, PhD, Kharitonov, Sergei A., MD, PhD, Meah, Sally, RGN, Barnes, Peter J., DM, DSc, Master FCCP, Usmani, Omar S., MBBS, PhD

“…Background Determining the site of airways inflammation may lead to the targeting of therapy. Nitric oxide (NO) is a biomarker of airway inflammation and can…”
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Effects of Aerosolized Adenosine 5′-Triphosphate in Smokers and Patients With COPD by Basoglu, Ozen K., MD, Barnes, Peter J., DM, DSc, Master FCCP, Kharitonov, Sergei A., MD, Pelleg, Amir, PhD

“…BACKGROUND Extracellular adenosine 5′-triphosphate (ATP) stimulates vagal C and Ad fibers in the lung, resulting in pronounced bronchoconstriction and cough…”
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Exhaled markers of pulmonary disease by KHARITONOV, Sergei A, BARNES, Peter J

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Pulmonary Biomarkers in Chronic Obstructive Pulmonary Disease by Barnes, Peter J, Chowdhury, Badrul, Kharitonov, Sergei A, Magnussen, Helgo, Page, Clive P, Postma, Dirkje, Saetta, Marina

“…There has been increasing interest in using pulmonary biomarkers to understand and monitor the inflammation in the respiratory tract of patients with chronic…”
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Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity by Brindicci, Caterina, Ito, Kazuhiro, Barnes, Peter J, Kharitonov, Sergei A

“…The majority of asthmatic patients achieve control of their illness; others do not. It is therefore crucial to validate/develop strategies that help the…”
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Increased 8-Isoprostane, a Marker of Oxidative Stress, in Exhaled Condensate of Asthma Patients by MONTUSCHI, PAOLO, CORRADI, MASSIMO, CIABATTONI, GIOVANNI, NIGHTINGALE, JULIA, KHARITONOV, SERGEI A, BARNES, PETER J

“…Oxidative stress has an important role in the pathogenesis of asthma. 8-Isoprostane is a prostaglandin (PG)-F2-like compound belonging to the F2 isoprostane…”
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Contrasting effects of ATP and adenosine on capsaicin challenge in asthmatic patients by Basoglu, Ozen K., MD, Pelleg, Amir, PhD, Kharitonov, Sergei A., MD, Barnes, Peter J., Master FRS

“…Abstract Background Adenosine 5’-triphosphate (ATP) stimulates pulmonary vagal slow conducting C-fibres and fast conducting Aδ-fibres with rapidly adapting…”
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8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy by Carpagnano, Giovanna E, Kharitonov, Sergei A, Resta, Onofrio, Foschino-Barbaro, Maria P, Gramiccioni, Enzo, Barnes, Peter J

“…Obstructive sleep apnea (OSA) is characterized by recurrent apnea during sleep that may compromise oxidative balance. Oxidative stress is increased in the…”
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Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients by Brindicci, Caterina, Ito, Kazuhiro, Torre, Olga, Barnes, Peter J, Kharitonov, Sergei A

“…Nitric oxide (NO) is produced by resident and inflammatory cells in the respiratory tract by the enzyme NO synthase (NOS), which exists in three isoforms:…”
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Increased nitrotyrosine in exhaled breath condensate of patients with asthma by HANAZAWA, Toyoyuki, KHARITONOV, Sergei A, BARNES, Peter J

“…The reaction of nitric oxide (NO) and superoxide anions (O(2)(-)) in the airway results in the formation of peroxynitrite, a highly reactive oxidant species…”
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Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients by Carpagnano, Giovanna E, Kharitonov, Sergei A, Resta, Onofrio, Foschino-Barbaro, Maria P, Gramiccioni, Enzo, Barnes, Peter J

“…Obstructive sleep apnea (OSA) is characterized by repeated episodes of upper airways obstruction during sleep that result in episodes of hypoxia. An increase…”
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Analysis of expired air for oxidation products by PAREDI, Paolo, KHARITONOV, Sergei A, BARNES, Peter J

“…Chronic inflammation is a critical feature of chronic obstructive pulmonary disease, cystic fibrosis, and asthma. This inflammation is associated with the…”
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Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases by CORRADI, Massimo, MONTUSCHI, Paolo, DONNELLY, Louise E, PESCI, Alberto, KHARITONOV, Sergei A, BARNES, Peter J

“…Nitrosothiols (RS-NOs) are formed by interaction of nitric oxide (NO) with glutathione and may limit the detrimental effect of NO. Because NO generation is…”
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Religious and Spiritual Biomarkers in Both Health and Disease by Kharitonov, Sergei A.

“…Religious thought and spirituality can be considered as a part of natural human capacities. There is an exponential rise in clinical research in the…”
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Airway responsiveness and inflammation in adolescent elite swimmers by Pedersen, Lars, MD, Lund, Thomas K., MD, Barnes, Peter J., DM, DSc, FRS, Kharitonov, Sergei A., MD, PhD, Backer, Vibeke, MD, DMSc

“…Background Whereas increased airway hyperresponsiveness (AHR) and airway inflammation are well documented in adult elite athletes, it remains uncertain whether…”
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Biomarkers of some pulmonary diseases in exhaled breath by Kharitonov, Sergei A., Barnes, Peter J.

“…Analysis of various biomarkers in exhaled breath allows completely non-invasive monitoring of inflammation and oxidative stress in the respiratory tract in…”
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Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils by Maneechotesuwan, Kittipong, Essilfie-Quaye, Sarah, Kharitonov, Sergei A, Adcock, Ian M, Barnes, Peter J

“…The role of neutrophils in exacerbations of asthma is poorly understood. We examined the effect of withdrawal of inhaled corticosteroids on sputum inflammatory…”
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A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics by Hansel, Trevor T., Kharitonov, Sergei A., Donnelly, Louise E., Erin, Edward M., Currie, Mark G., Moore, William M., Manning, Pamela T., Recker, David P., Barnes, Peter J.

“…ABSTRACT The inducible isoenzyme of nitric oxide synthase (iNOS) generates nitric oxide (NO) in inflammatory diseases such as asthma. The prodrug…”
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Elevation of exhaled ethane concentration in asthma by PAREDI, Paolo, KHARITONOV, Sergei A, BARNES, Peter J

“…Ethane is a product of lipid peroxidation as a result of oxidative stress and can be detected in the exhaled air. Oxidative stress plays a role in the…”
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