Search Results - "KHALILI, Kamel"

Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease by Tahrir, Farzaneh G., Langford, Dianne, Amini, Shohreh, Mohseni Ahooyi, Taha, Khalili, Kamel

“…Mitochondria play an important role in maintaining cardiac homeostasis by supplying the major energy required for cardiac excitation–contraction coupling as…”
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Magnetically guided non-invasive CRISPR-Cas9/gRNA delivery across blood-brain barrier to eradicate latent HIV-1 infection by Kaushik, Ajeet, Yndart, Adriana, Atluri, Venkata, Tiwari, Sneham, Tomitaka, Asahi, Gupta, Purnima, Jayant, Rahul Dev, Alvarez-Carbonell, David, Khalili, Kamel, Nair, Madhavan

“…CRISPR-Cas9/gRNA exhibits therapeutic efficacy against latent human immunodeficiency virus (HIV) genome but the delivery of this therapeutic cargo to the brain…”
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Viruses and Human Cancers: a Long Road of Discovery of Molecular Paradigms by WHITE, Martyn K, PAGANO, Joseph S, KHALILI, Kamel

“…About a fifth of all human cancers worldwide are caused by infectious agents. In 12% of cancers, seven different viruses have been causally linked to human…”
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RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection by Hu, Wenhui, Kaminski, Rafal, Yang, Fan, Zhang, Yonggang, Cosentino, Laura, Li, Fang, Luo, Biao, Alvarez-Carbonell, David, Garcia-Mesa, Yoelvis, Karn, Jonathan, Mo, Xianming, Khalili, Kamel

“…AIDS remains incurable due to the permanent integration of HIV-1 into the host genome, imparting risk of viral reactivation even after antiretroviral therapy…”
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CRISPR based editing of SIV proviral DNA in ART treated non-human primates by Mancuso, Pietro, Chen, Chen, Kaminski, Rafal, Gordon, Jennifer, Liao, Shuren, Robinson, Jake A., Smith, Mandy D., Liu, Hong, Sariyer, Ilker K., Sariyer, Rahsan, Peterson, Tiffany A., Donadoni, Martina, Williams, Jaclyn B., Siddiqui, Summer, Bunnell, Bruce A., Ling, Binhua, MacLean, Andrew G., Burdo, Tricia H., Khalili, Kamel

“…Elimination of HIV DNA from infected individuals remains a challenge in medicine. Here, we demonstrate that intravenous inoculation of SIV-infected macaques, a…”
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In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models by Yin, Chaoran, Zhang, Ting, Qu, Xiying, Zhang, Yonggang, Putatunda, Raj, Xiao, Xiao, Li, Fang, Xiao, Weidong, Zhao, Huaqing, Dai, Shen, Qin, Xuebin, Mo, Xianming, Young, Won-Bin, Khalili, Kamel, Hu, Wenhui

“…CRISPR-associated protein 9 (Cas9)-mediated genome editing provides a promising cure for HIV-1/AIDS; however, gene delivery efficiency in vivo remains an…”
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Induction of Brain Tumors by the Archetype Strain of Human Neurotropic JCPyV in a Transgenic Mouse Model by Del Valle, Luis, Khalili, Kamel

“…JC Virus (JCPyV), a member of the family, is a human neurotropic virus with world-wide distribution. JCPyV is the established opportunistic infectious agent of…”
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Oncogenic viruses and tumor glucose metabolism: like kids in a candy store by Noch, Evan, Khalili, Kamel

“…Oncogenic viruses represent a significant public health burden in light of the multitude of malignancies that result from chronic or spontaneous viral…”
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Persistence and pathogenesis of the neurotropic polyomavirus JC by Wollebo, Hassen S., White, Martyn K., Gordon, Jennifer, Berger, Joseph R., Khalili, Kamel

“…Many neurological diseases of the central nervous system (CNS) are underpinned by malfunctions of the immune system, including disorders involving…”
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Molecular mechanisms of necrosis in glioblastoma: The role of glutamate excitotoxicity by Noch, Evan, Khalili, Kamel

“…Glioblastomas continue to rank among the most lethal primary human tumors.  Despite treatment with the most rigorous surgical interventions along with the most…”
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Molecular Biology, Epidemiology, and Pathogenesis of Progressive Multifocal Leukoencephalopathy, the JC Virus-Induced Demyelinating Disease of the Human Brain by FERENCZY, Michael W, MARSHALL, Leslie J, NELSON, Christian D. S, ATWOOD, Walter J, NATH, Avindra, KHALILI, Kamel, MAJOR, Eugene O

“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The rapidly expanding family of human polyomaviruses: recent developments in understanding their life cycle and role in human pathology by White, Martyn K, Gordon, Jennifer, Khalili, Kamel

“…Since their discovery in 1971, the polyomaviruses JC (JCPyV) and BK (BKPyV), isolated from patients with progressive multifocal leukoencephalopathy and…”
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Protein Quality Control in Glioblastoma: A Review of the Current Literature with New Perspectives on Therapeutic Targets by Rocchi, Angela, Wollebo, Hassen S., Khalili, Kamel

“…Protein quality control allows eukaryotes to maintain proteostasis under the stress of constantly changing conditions. In this review, we discuss the current…”
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CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs by Zhang, Yonggang, Yin, Chaoran, Zhang, Ting, Li, Fang, Yang, Wensheng, Kaminski, Rafal, Fagan, Philip Regis, Putatunda, Raj, Young, Won-Bin, Khalili, Kamel, Hu, Wenhui

“…Current antiretroviral therapy does not eliminate the integrated and transcriptionally silent HIV-1 provirus in latently infected cells. Recently, a “shock and…”
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Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS by Yin, Chaoran, Zhang, Ting, Li, Fang, Yang, Fan, Putatunda, Raj, Young, Won-Bin, Khalili, Kamel, Hu, Wenhui, Zhang, Yonggang

“…OBJECTIVE:There is an urgent need for the development of HIV-1 genome eradication strategies that lead to a permanent cure for HIV-1/AIDS. We previously…”
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CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection by Wollebo, Hassen S, Bellizzi, Anna, Kaminski, Rafal, Hu, Wenhui, White, Martyn K, Khalili, Kamel

“…Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system (CNS) caused by reactivation of the human…”
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Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers by Kaushik, Ajeet, Jayant, Rahul D., Nikkhah-Moshaie, Roozbeh, Bhardwaj, Vinay, Roy, Upal, Huang, Zaohua, Ruiz, Ariel, Yndart, Adriana, Atluri, Venkata, El-Hage, Nazira, Khalili, Kamel, Nair, Madhavan

“…Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to…”
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Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes by Tahrir, Farzaneh G., Knezevic, Tijana, Gupta, Manish K., Gordon, Jennifer, Cheung, Joseph Y., Feldman, Arthur M., Khalili, Kamel

“…Mitochondrial abnormalities impact the development of myofibrillar myopathies. Therefore, understanding the mechanisms underlying the removal of dysfunctional…”
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Gene Editing Approaches against Viral Infections and Strategy to Prevent Occurrence of Viral Escape by White, Martyn K, Hu, Wenhui, Khalili, Kamel

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Regulation of Gene Expression in Primate Polyomaviruses by WHITE, Martyn K, SAFAK, Mahmut, KHALILI, Kamel

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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