Search Results - "KEYVANFAR, Keyvan"

A CD19/CD3 bispecific antibody for effective immunotherapy of chronic lymphocytic leukemia in the ibrutinib era by Robinson, Hannah R., Qi, Junpeng, Cook, Erika M., Nichols, Cydney, Dadashian, Eman L., Underbayev, Chingiz, Herman, Sarah E.M., Saba, Nakhle S., Keyvanfar, Keyvan, Sun, Clare, Ahn, Inhye E., Baskar, Sivasubramanian, Rader, Christoph, Wiestner, Adrian

“…The Bruton tyrosine kinase inhibitor ibrutinib induces high rates of clinical response in chronic lymphocytic leukemia (CLL). However, there remains a need for…”
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Long noncoding RNAs of single hematopoietic stem and progenitor cells in healthy and dysplastic human bone marrow by Wu, Zhijie, Gao, Shouguo, Zhao, Xin, Chen, Jinguo, Keyvanfar, Keyvan, Feng, Xingmin, Kajigaya, Sachiko, Young, Neal S

“…Long noncoding RNAs (lncRNAs) are regulators of cell differentiation and development. The lncRNA transcriptome in human hematopoietic stem and progenitor cells…”
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Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells by Zhao, Xin, Gao, Shouguo, Wu, Zhijie, Kajigaya, Sachiko, Feng, Xingmin, Liu, Qingguo, Townsley, Danielle M., Cooper, James, Chen, Jinguo, Keyvanfar, Keyvan, Fernandez Ibanez, Maria del Pilar, Wang, Xujing, Young, Neal S.

“…Cancer cells frequently exhibit chromosomal abnormalities. Specific cytogenetic aberrations often are predictors of outcome, especially in hematologic…”
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Rapamycin is highly effective in murine models of immune-mediated bone marrow failure by Feng, Xingmin, Lin, Zenghua, Sun, Wanling, Hollinger, Maile K, Desierto, Marie J, Keyvanfar, Keyvan, Malide, Daniela, Muranski, Pawel, Chen, Jichun, Young, Neal S

“…Acquired aplastic anemia, the prototypical bone marrow failure disease, is characterized by pancytopenia and marrow hypoplasia. Most aplastic anemia patients…”
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Th17 immune responses contribute to the pathophysiology of aplastic anemia by de Latour, Regis Peffault, Visconte, Valeria, Takaku, Tomoiku, Wu, Colin, Erie, Andrew J., Sarcon, Annahita K., Desierto, Marie J., Scheinberg, Phillip, Keyvanfar, Keyvan, Nunez, Olga, Chen, Jichun, Young, Neal S.

“…T helper type 17 (Th17) cells have been characterized based on production of interleukin-17 (IL-17) and association with autoimmune diseases. We studied the…”
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T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways by Hosokawa, Kohei, Kajigaya, Sachiko, Keyvanfar, Keyvan, Qiao, Wangmin, Xie, Yanling, Townsley, Danielle M, Feng, Xingmin, Young, Neal S

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder originating from hematopoietic stem cells and is a life-threating disease characterized…”
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Th17/Treg ratio in human graft-versus-host disease by Ratajczak, Philippe, Janin, Anne, Peffault de Latour, Regis, Leboeuf, Christophe, Desveaux, Allison, Keyvanfar, Keyvan, Robin, Marie, Clave, Emmanuel, Douay, Corine, Quinquenel, Anne, Pichereau, Claire, Bertheau, Philippe, Mary, Jean Yves, Socié, Gérard

“…Th17 cells have never been explored in human graft-versus-host disease (GVHD). We studied the correlation between the presence of Th17 cells with histologic…”
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Robust generation of erythroid and multilineage hematopoietic progenitors from human iPSCs using a scalable monolayer culture system by Ruiz, Juan Pablo, Chen, Guibin, Haro Mora, Juan Jesus, Keyvanfar, Keyvan, Liu, Chengyu, Zou, Jizhong, Beers, Jeanette, Bloomer, Hanan, Qanash, Husam, Uchida, Naoya, Tisdale, John F., Boehm, Manfred, Larochelle, Andre

“…•Monolayer-based culture system for hematopoietic differentiation of human iPSCs.•Successive emergence of primitive and definitive hematopoietic…”
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Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1 by Herishanu, Yair, Gibellini, Federica, Njuguna, Ndegwa, Hazan-Halevy, Inbal, Farooqui, Mohammed, Bern, Sarah, Keyvanfar, Keyvan, Lee, Elinor, Wilson, Wyndham, Wiestner, Adrian

“…Survival of chronic lymphocytic leukemia (CLL) cells in vivo is supported by the tissue microenvironment, which includes components of the extracellular…”
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Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells by Ito, Sawa, Barrett, A. John, Dutra, Amalia, Pak, Evgenia, Miner, Samantha, Keyvanfar, Keyvan, Hensel, Nancy F., Rezvani, Katayoun, Muranski, Pawel, Liu, Paul, Melenhorst, J. Joseph, Larochelle, Andre

“…Mesenchymal stromal cells (MSCs) support the growth and differentiation of normal hematopoietic stem cells (HSCs). Here we studied the ability of MSCs to…”
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Regulated Apoptosis of Genetically Modified Hematopoietic Stem and Progenitor Cells Via an Inducible Caspase‐9 Suicide Gene in Rhesus Macaques by Barese, Cecilia N., Felizardo, Tania C., Sellers, Stephanie E., Keyvanfar, Keyvan, Di Stasi, Antonio, Metzger, Mark E., Krouse, Allen E., Donahue, Robert E., Spencer, David M., Dunbar, Cynthia E.

“…The high risk of insertional oncogenesis reported in clinical trials using integrating retroviral vectors to genetically modify hematopoietic stem and…”
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Ex Vivo-Generated CD36+ Erythroid Progenitors Are Highly Permissive to Human Parvovirus B19 Replication by SUSAN WONG, NING ZHI, FILIPPONE, Claudia, KEYVANFAR, Keyvan, KAJIGAYA, Sachiko, BROWN, Kevin E, YOUNG, Neal S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of novel microRNA signatures linked to acquired aplastic anemia by Hosokawa, Kohei, Muranski, Pawel, Feng, Xingmin, Keyvanfar, Keyvan, Townsley, Danielle M, Dumitriu, Bogdan, Chen, Jichun, Kajigaya, Sachiko, Taylor, James G, Hourigan, Christopher S, Barrett, A John, Young, Neal S

“…Emerging evidence indicates that microRNA control and modulate immunity. MicroRNA have not been investigated in acquired aplastic anemia, a T-cell-mediated…”
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PPARγ antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function by Sato, Kazuya, Feng, Xingmin, Chen, Jichun, Li, Jungang, Muranski, Pawel, Desierto, Marie J, Keyvanfar, Keyvan, Malide, Daniela, Kajigaya, Sachiko, Young, Neal S

“…Acquired aplastic anemia is an immune-mediated disease, in which T cells target hematopoietic cells; at presentation, the bone marrow is replaced by fat. It…”
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Quantitative activation suppression assay to evaluate human bone marrow–derived mesenchymal stromal cell potency by Salem, Bahey, Miner, Samantha, Hensel, Nancy F, Battiwalla, Minoo, Keyvanfar, Keyvan, Stroncek, David F, Gee, Adrian P, Hanley, Patrick J, Bollard, Catherine M, Ito, Sawa, Barrett, A. John

“…Abstract Background aims With the increasing use of cell therapies involving immune modulatory cells, there is a need for a simple standardized method to…”
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Whole transcriptome sequencing identifies increased CXCR2 expression in PNH granulocytes by Hosokawa, Kohei, Kajigaya, Sachiko, Keyvanfar, Keyvan, Qiao, Wangmin, Xie, Yanling, Biancotto, Angelique, Townsley, Danielle M., Feng, Xingmin, Young, Neal S.

“…Summary The aetiology of paroxysmal nocturnal haemoglobinuria (PNH) is a somatic mutation in the X‐linked phosphatidylinositol glycan class A gene (PIGA),…”
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Correction to: Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation by Demirci, Selami, Haro-Mora, Juan J, Leonard, Alexis, Drysdale, Claire, Malide, Daniela, Keyvanfar, Keyvan, Essawi, Khaled, Vizcardo, Raul, Tamaoki, Naritaka, Restifo, Nicholas P, Tisdale, John F, Uchida, Naoya

“…An amendment to this paper has been published and can be accessed via the original article…”
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Eltrombopag Improves Erythroid Differentiation in a Human Induced Pluripotent Stem Cell Model of Diamond Blackfan Anemia by Qanash, Husam, Li, Yongqin, Smith, Richard H, Linask, Kaari, Young-Baird, Sara, Hakami, Waleed, Keyvanfar, Keyvan, Choy, John S, Zou, Jizhong, Larochelle, Andre

“…Diamond Blackfan Anemia (DBA) is a congenital macrocytic anemia associated with ribosomal protein haploinsufficiency. Ribosomal dysfunction delays globin…”
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Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing by Banaszak, Lauren G., Giudice, Valentina, Zhao, Xin, Wu, Zhijie, Gao, Shouguo, Hosokawa, Kohei, Keyvanfar, Keyvan, Townsley, Danielle M., Gutierrez-Rodrigues, Fernanda, Fernandez Ibanez, Maria del Pilar, Kajigaya, Sachiko, Young, Neal S.

“…DNA methyltransferase 3A (DNMT3A) mediates de novo DNA methylation. Mutations in DNMT3A are associated with hematological malignancies, most frequently acute…”
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Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia by Aue, Georg, Njuguna, Ndegwa, Tian, Xin, Soto, Susan, Hughes, Thomas, Vire, Berengere, Keyvanfar, Keyvan, Gibellini, Federica, Valdez, Janet, Boss, Carol, Samsel, Leigh, McCoy, J. Philip, Jr, Wilson, Wyndham H, Pittaluga, Stefania, Wiestner, Adrian

“…1 Hematology Branch, NHLBI 2 Office of Biostatistics Research, NHLBI 3 Department of Pharmacy, Clinical Center 4 Flow Cytometry Core Facility, NHLBI 5…”
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