Search Results - "KEUTMANN, H. T"

Structural Organization of the Nine Spectrin Repeats of Kalirin by Vishwanatha, K. S, Wang, Y. P, Keutmann, H. T, Mains, R. E, Eipper, B. A

“…Sequence analysis suggests that KALRN, a Rho GDP/GTP exchange factor genetically linked to schizophrenia, could contain as many as nine tandem spectrin repeats…”
Get full text

The extracellular amino-terminal region of the parathyroid hormone (PTH)/PTH-related peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH-(1-34) by Jüppner, H, Schipani, E, Bringhurst, F R, McClure, I, Keutmann, H T, Potts, Jr, J T, Kronenberg, H M, Abou-Samra, A B, Segre, G V, Gardella, T J

“…The recombinant human PTH/PTH-related peptide (PTHrP) receptor, when transiently expressed in COS-7 cells, binds [Nle8,18,Tyr34] bovine PTH-(7-34)amide…”
Get more information

Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia by Nussbaum, S R, Zahradnik, R J, Lavigne, J R, Brennan, G L, Nozawa-Ung, K, Kim, L Y, Keutmann, H T, Wang, C A, Potts, Jr, J T, Segre, G V

“…We have developed a highly sensitive, two-site immunoradiometric assay (IRMA) for human parathyrin (PTH) that is specific for the intact, secreted,…”
Get more information

The glycoprotein hormones: recent studies of structure-function relationships by Ryan, R J, Charlesworth, M C, McCormick, D J, Milius, R P, Keutmann, H T

“…The structural features of the heterodimeric glycoprotein hormones (LH, FSH, TSH, and hCG) are briefly reviewed. Removal of carbohydrate chains does not reduce…”
Get more information

Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine alpha-amidating monooxygenase (PAM) by EIPPER, B. A, GREEN, C. B.-R, CAMPBELL, T. A, STOFFERS, D. A, KEUTMANN, H. T, MAINS, R. E, OUAFIK, H

“…The pituitary is a rich source of peptidylglycine alpha-amidating monooxygenase (PAM). This bifunctional protein contains peptidylglycine alpha-hydroxylating…”
Get full text

A Receptor-Binding Region in Human Choriogonadotropin/Lutropin β Subunit by Keutmann, Henry T., Charlesworth, M. Cristine, Mason, Kathleen A., Ostrea, Teofila, Johnson, Leslie, Ryan, Robert J.

“…Synthetic fragments have not been widely used thus far to evaluate structure-activity relations in the glycoprotein hormones. We prepared a series of peptides…”
Get full text

Use of endoproteases to identify catalytic domains, linker regions, and functional interactions in soluble peptidylglycine alpha-amidating monooxygenase by HUSTEN, E. J, TAUSK, F. A, KEUTMANN, H. T, EIPPER, B. A

“…The production of alpha-amidated peptides is accomplished through the sequential action of two enzymes, peptidylglycine alpha-hydroxylating monooxygenase (PHM)…”
Get full text

Mutational analysis of the receptor-activating region of human parathyroid hormone by T J Gardella, D Axelrod, D Rubin, H T Keutmann, J T Potts, Jr, H M Kronenberg, S R Nussbaum

“…The first 4 residues of parathyroid hormone (PTH) are highly conserved in evolution and are important for biological activity. We randomly mutated codons 1-4…”
Get full text

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase. Purification, characterization, and expression by Eipper, B A, Perkins, S N, Husten, E J, Johnson, R C, Keutmann, H T, Mains, R E

“…The production of alpha-amidated peptides from their glycine-extended precursors is a two-step process involving the sequential action of two catalytic domains…”
Get full text

Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine alpha-amidating monooxygenase by HYE-YOUNG YUN, KEUTMANN, H. T, EIPPER, B. A

“…Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the COOH-terminal alpha-amidation of neuro-endocrine peptides through the sequential action of…”
Get full text

Analysis of parathyroid hormone's principal receptor-binding region by site-directed mutagenesis and analog design by Gardella, T J, Wilson, A K, Keutmann, H T, Oberstein, R, Potts, Jr, J T, Kronenberg, M, Nussbaum, S R

“…Previous deletion studies established that the 25-34 region of PTH is important for receptor binding. We used oligonucleotide-directed mutagenesis to generate…”
Get more information

Developmental regulation of peptidylglycine alpha-amidating monooxygenase (PAM) in rat heart atrium and ventricle. Tissue-specific changes in distribution of PAM activity, mRNA levels, and protein forms by Ouafik, L, May, V, Keutmann, H T, Eipper, B A

“…The high levels of peptidylglycine alpha-amidating monooxygenase (PAM, EC 1.14.17.3) found in adult rat atrium led us to examine PAM expression in rat atrium…”
Get full text

Receptor-binding regions in human glycoprotein hormones by Keutmann, H T

Get more information

α-Enolase is restricted to basal cells of stratified squamous epithelium by Zieske, James D., Bukusoglu, Gül, Yankauckas, Michelle A., Wasson, Michael E., Keutmann, Henry T.

“…We have developed a monoclonal antibody against a 50-kDa protein that binds preferentially to basal cells in the limbus of rat, rabbit, and human corneas (J…”
Get full text

Amidation of joining peptide, a major pro-ACTH/endorphin-derived product peptide by Eipper, B A, Park, L, Keutmann, H T, Mains, R E

“…Based on sequence data, rat and mouse pro-adrenocorticotropin (ACTH)/endorphin could give rise to joining peptide, a short acidic peptide that could terminate…”
Get full text

Intracellular and Extracellular Processing of Human Apolipoprotein A-I: Secreted Apolipoprotein A-I Isoprotein 2 is a Propeptide by Zannis, V. I., Karathanasis, S. K., Keutmann, H. T., Goldberger, G., Breslow, J. L.

“…We have recently proposed that the major secreted isoprotein form of human apolipoprotein A-I (designated apo A-I2) is modified extracellularly to become the…”
Get full text

Architectural Rules of the Zinc-Finger Motif: Comparative Two-Dimensional NMR Studies of Native and "Aromatic-Swap" Domains Define a "Weakly Polar Switch" by Kochoyan, Michel, Keutmann, Henry T., Weiss, Michael A.

“…The Zn-finger motif, encoding a globular minidomain with characteristic structure, provides a striking example of a sequence template for protein folding…”
Get full text

Expression of human parathyroid hormone-(1-84) in Escherichia coli as a factor X-cleavable fusion protein by T J Gardella, D Rubin, A B Abou-Samra, H T Keutmann, J T Potts, Jr, H M Kronenberg, S R Nussbaum

“…Recombinant human parathyroid hormone (hPTH)-(1-84) was obtained from Escherichia coli using a cleavable fusion protein strategy. The fusion protein contains…”
Get full text

A receptor binding site identified in the region 81-95 of the beta-subunit of human luteinizing hormone (LH) and chorionic gonadotropin (hCG) by Morbeck, D E, Roche, P C, Keutmann, H T, McCormick, D J

“…Two series of overlapping peptides comprising the entire sequences of the beta-subunits of human lutropin (LH) and choriogonadotropin (hCG) were prepared by a…”
Get more information

Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for jumping-linker DNA recognition by Kochoyan, Michel, Havel, Timothy F, Nguyen, Dzung T, Dahl, Charles E, Keutmann, Henry T, Weiss, Michael A

“…ZFY, a sex-related Zn-finger protein encoded by the human Y chromosome, is distinguished from the general class of Zn-finger proteins by the presence of a…”
Get full text