Search Results - "KETTRITZ, Ralph"

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis by Schreiber, Adrian, Rousselle, Anthony, Becker, Jan Ulrich, von Mässenhausen, Anne, Linkermann, Andreas, Kettritz, Ralph

“…Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) constitutes life-threatening autoimmune diseases affecting every organ, including the…”
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Clonal hematopoiesis in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis by Arends, Christopher Maximilian, Weiss, Marlene, Christen, Friederike, Eulenberg-Gustavus, Claudia, Rousselle, Anthony, Kettritz, Ralph, Eckardt, Kai-Uwe, Chan, Willy, Hoyer, Kaja, Frick, Mareike, Bullinger, Lars, Bieringer, Markus, Schreiber, Adrian, Damm, Frederik

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C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis by Schreiber, Adrian, Xiao, Hong, Jennette, J Charles, Schneider, Wolfgang, Luft, Friedrich C, Kettritz, Ralph

“…Anti-neutrophil cytoplasmic autoantibody (ANCA)-induced necrotizing crescentic glomerulonephritis (NCGN) requires complement participation in its pathogenesis…”
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Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets by Eulenberg-Gustavus, Claudia, Bähring, Sylvia, Maass, Philipp G, Luft, Friedrich C, Kettritz, Ralph

“…CD177 presents antigens in allo- and autoimmune diseases on the neutrophil surface. Individuals can be either CD177-deficient or harbor distinct CD177 and…”
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Dipeptidyl peptidase 1 inhibition as a potential therapeutic approach in neutrophil-mediated inflammatory disease by Chalmers, James D, Kettritz, Ralph, Korkmaz, Brice

“…Neutrophils have a critical role in the innate immune response to infection and the control of inflammation. A key component of this process is the release of…”
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Neutrophil serine proteases exert proteolytic activity on endothelial cells by Jerke, Uwe, Hernandez, Daniel Perez, Beaudette, Patrick, Korkmaz, Brice, Dittmar, Gunnar, Kettritz, Ralph

“…Neutrophil serine proteases (NSPs) are released from activated neutrophils during inflammation. Here we studied the transfer of the three major NSPs, namely…”
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The neutrophil in antineutrophil cytoplasmic autoantibody-associated vasculitis by Schreiber, Adrian, Kettritz, Ralph

“…Review of ANCA‐neutrophil interactions and how mouse models helped to establish disease mechanisms and novel treatment targets. Necrotizing, small‐vessel…”
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Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes by Singer, Eugenia, Elger, Antje, Elitok, Saban, Kettritz, Ralph, Nickolas, Thomas L., Barasch, Jonathan, Luft, Friedrich C., Schmidt-Ott, Kai M.

“…In established acute kidney injury (AKI), serum creatinine poorly differentiates prerenal from intrinsic AKI. In this study, we tested whether urinary…”
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β2-integrins control HIF1α activation in human neutrophils by Kling, Lovis, Eulenberg-Gustavus, Claudia, Jerke, Uwe, Rousselle, Anthony, Eckardt, Kai-Uwe, Schreiber, Adrian, Kettritz, Ralph

“…During inflammation, human neutrophils engage β 2 -integrins to migrate from the blood circulation to inflammatory sites with high cytokine but low oxygen…”
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Protective α1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation by Ebert, Maximilian, Jerke, Uwe, Eulenberg-Gustavus, Claudia, Kling, Lovis, Jenne, Dieter, Kirchner, Marieluise, Mertins, Philipp, Bieringer, Markus, Elitok, Saban, Eckardt, Kai-Uwe, Schreiber, Adrian, Salama, Alan D, Kettritz, Ralph

“…BackgroundAntineutrophil cytoplasmic autoantibody-associated (ANCA-associated) vasculitidies (AAV) are life-threatening systemic autoimmune conditions. ANCAs…”
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β2 Integrin-mediated Cell-Cell Contact Transfers Active Myeloperoxidase from Neutrophils to Endothelial Cells by Jerke, Uwe, Rolle, Susanne, Purfürst, Bettina, Luft, Friedrich C., Nauseef, William M., Kettritz, Ralph

“…Atherosclerosis and vasculitis both feature inflammation mediated by neutrophil-endothelial cell (EC) contact. Neutrophil myeloperoxidase (MPO) can disrupt…”
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Complement Receptor Mac-1 Is an Adaptor for NB1 (CD177)-mediated PR3-ANCA Neutrophil Activation by Jerke, Uwe, Rolle, Susanne, Dittmar, Gunnar, Bayat, Behnaz, Santoso, Sentot, Sporbert, Anje, Luft, Friedrich, Kettritz, Ralph

“…The glycosylphosphatidylinositol (GPI)-anchored neutrophil-specific receptor NB1 (CD177) presents the autoantigen proteinase 3 (PR3) on the membrane of a…”
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Genetic Background but Not Intestinal Microbiota After Co-Housing Determines Hyperoxaluria-Related Nephrocalcinosis in Common Inbred Mouse Strains by Ma, Qiuyue, Grigorescu, Melissa, Schreiber, Adrian, Kettritz, Ralph, Lindenmeyer, Maja, Anders, Hans-Joachim, Steiger, Stefanie

“…Calcium oxalate (CaOx) crystal formation, aggregation and growth is a common cause of kidney stone disease and nephrocalcinosis-related chronic kidney disease…”
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Myeloperoxidase-Specific Plasma Cell Depletion by Bortezomib Protects from Anti-Neutrophil Cytoplasmic Autoantibodies-induced Glomerulonephritis by BONTSCHO, Julia, SCHREIBER, Adrian, MANZ, Rudolf A, SCHNEIDER, Wolfgang, LUFT, Friedrich C, KETTRITZ, Ralph

“…Anti-neutrophil cytoplasmic autoantibodies (ANCA) cause vasculitis and necrotizing crescentic glomerulonephritis (NCGN). Steroids and cytotoxic drugs reduce…”
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NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils by von Vietinghoff, Sibylle, Tunnemann, Gisela, Eulenberg, Claudia, Wellner, Maren, Cristina Cardoso, M., Luft, Friedrich C., Kettritz, Ralph

“…Antineutrophil cytoplasmic antibodies (ANCAs) with specificity for proteinase 3 (PR3) are central to a form of ANCA-associated vasculitis. Membrane PR3 (mPR3)…”
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Neutral serine proteases of neutrophils by Kettritz, Ralph

“…Summary Neutrophil serine proteases (NSPs) exercise tissue‐degrading and microbial‐killing effects. The spectrum of NSP‐mediated functions grows continuously,…”
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Membrane expression of proteinase 3 is genetically determined by SCHREIBER, Adrian, BUSJAHN, Andreas, LUFT, Friedrich C, KETTRITZ, Ralph

“…Isolated human neutrophils exhibit a bimodal membrane proteinase 3 (PR3) expression. PR3 is the main target antigen in Wegener granulomatosis (WG). Cells with…”
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Dysnatremias - concepts and clinical work-up by Kettritz, Ralph

“…Osmotic gradients over cell membranes lead to water movement into or out of cells. An intact osmoregulation prevents osmotic gradients, thereby protecting…”
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Potassium homeostasis – Physiology and pharmacology in a clinical context by Kettritz, Ralph, Loffing, Johannes

“…Membrane voltage controls the function of excitable cells and is mainly a consequence of the ratio between the extra- and intracellular potassium…”
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Cardiovascular Magnetic Resonance Imaging Detects Cardiac Involvement in Churg-Strauss Syndrome by Wassmuth, Ralf, MD, Göbel, Ursula, MD, Natusch, Alexander, MD, Schneider, Wolfgang, MD, Kettritz, Ralph, MD, Dietz, Rainer, MD, Luft, Friedrich C., MD, Schulz-Menger, Jeanette, MD

“…Abstract Background Cardiac involvement in Churg-Strauss vasculitis worsens the prognosis. Early detection is, therefore, warranted. Cardiac magnetic resonance…”
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