Search Results - "KERWIN, Edward"

Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti-IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma by BUSSE, William W, HOLGATE, Stephen, KERWIN, Edward, YUN CHON, JINGYUAN FENG, LIN, Joseph, LIN, Shao-Lee

“…IL-17 signaling has been implicated in development and persistence of asthma. Cytokine-targeted strategies blocking IL-17 receptor signaling may be beneficial…”
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Efficacy and safety of fixed-dose combinations of aclidinium bromide/formoterol fumarate: the 24-week, randomized, placebo-controlled AUGMENT COPD study by D'Urzo, Anthony D, Rennard, Stephen I, Kerwin, Edward M, Mergel, Victor, Leselbaum, Anne R, Caracta, Cynthia F

“…Combining two long-acting bronchodilators with complementary mechanisms of action may provide treatment benefits to patients with chronic obstructive pulmonary…”
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Efficacy of umeclidinium/vilanterol versus umeclidinium and salmeterol monotherapies in symptomatic patients with COPD not receiving inhaled corticosteroids: the EMAX randomised trial by Maltais, François, Bjermer, Leif, Kerwin, Edward M, Jones, Paul W, Watkins, Michael L, Tombs, Lee, Naya, Ian P, Boucot, Isabelle H, Lipson, David A, Compton, Chris, Vahdati-Bolouri, Mitra, Vogelmeier, Claus F

“…Prospective evidence is lacking regarding incremental benefits of long-acting dual- versus mono-bronchodilation in improving symptoms and preventing short-term…”
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Safety and Immunogenicity of a Respiratory Syncytial Virus Prefusion F (RSVPreF3) Candidate Vaccine in Older Adults: Phase 1/2 Randomized Clinical Trial by Leroux-Roels, Isabel, Davis, Matthew G, Steenackers, Katie, Essink, Brandon, Vandermeulen, Corinne, Fogarty, Charles, Andrews, Charles P, Kerwin, Edward, David, Marie-Pierre, Fissette, Laurence, Vanden Abeele, Carline, Collete, Delphine, de Heusch, Magali, Salaun, Bruno, De Schrevel, Nathalie, Koch, Juliane, Verheust, Céline, Dezutter, Nancy, Struyf, Frank, Mesaros, Narcisa, Tica, Jelena, Hulstrøm, Veronica

“…Abstract Background The aim of this study was to investigate safety and immunogenicity of vaccine formulations against respiratory syncytial virus (RSV)…”
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Relationship between handheld and clinic-based spirometry measurements in asthma patients receiving beclomethasone by Kerwin, Edward M., Hickey, Lisa, Small, Calvin J.

“…Handheld spirometers for home use by patients allow longitudinal spirometry data to be collected daily and may overcome some of the limitations of in-clinic…”
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A randomised trial of fluticasone furoate/vilanterol (50/25 μg; 100/25 μg) on lung function in COPD by Kerwin, Edward M, Scott-Wilson, Catherine, Sanford, Lisa, Rennard, Stephen, Agusti, Alvar, Barnes, Neil, Crim, Courtney

“…Summary Background Fluticasone furoate (FF)/vilanterol (VI) is a novel once-daily inhaled corticosteroid/long-acting β2 -agonist combination therapy for COPD…”
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Weighing the evidence for pharmacological treatment interventions in mild COPD; a narrative perspective by Singh, Dave, D'Urzo, Anthony D, Donohue, James F, Kerwin, Edward M

“…There is increasing focus on understanding the nature of chronic obstructive pulmonary disease (COPD) during the earlier stages. Mild COPD (Global Initiative…”
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Bone and ocular safety of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler in COPD: a 52-week randomized study by Kerwin, Edward M, Ferguson, Gary T, Mo, Mindy, DeAngelis, Kiernan, Dorinsky, Paul

“…Long-term use of inhaled corticosteroids (ICSs) has been associated with increased risk of bone and ocular comorbidities. We evaluated the effects of the…”
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Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients by Busse, William W., MD, Wenzel, Sally E., MD, Meltzer, Eli O., MD, Kerwin, Edward M., MD, Liu, Mark C., MD, Zhang, Nan, PhD, Chon, Yun, PhD, Budelsky, Alison L., PhD, Lin, Joseph, MD, Lin, Shao-Lee, MD, PhD

“…Background The D-prostanoid receptor and the chemoattractant receptor homologous molecule expressed on TH 2 cells (CRTH2) are implicated in asthma…”
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Efficacy and safety of umeclidinium plus vilanterol versus tiotropium, vilanterol, or umeclidinium monotherapies over 24 weeks in patients with chronic obstructive pulmonary disease: results from two multicentre, blinded, randomised controlled trials by Decramer, Marc, Dr Prof, Anzueto, Antonio, Prof, Kerwin, Edward, MD, Kaelin, Thomas, DO, Richard, Nathalie, MSc, Crater, Glenn, MD, Tabberer, Maggie, MSc, Harris, Stephanie, BSc, Church, Alison, MD

“…Summary Background Combination long-acting bronchodilator treatment might be more effective than long-acting bronchodilator monotherapy for the treatment of…”
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Budesonide/formoterol MDI with co-suspension delivery technology in COPD: the TELOS study by Ferguson, Gary T, Papi, Alberto, Anzueto, Antonio, Kerwin, Edward M, Cappelletti, Christy, Duncan, Elizabeth A, Nyberg, Jack, Dorinsky, Paul

“…TELOS compared budesonide (BD)/formoterol fumarate dihydrate (FF) metered dose inhaler (BFF MDI), formulated using innovative co-suspension delivery technology…”
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Initial analysis of viral dynamics and circulating viral variants during the mRNA-1273 Phase 3 COVE trial by Pajon, Rolando, Paila, Yamuna D., Girard, Bethany, Dixon, Groves, Kacena, Katherine, Baden, Lindsey R., El Sahly, Hana M., Essink, Brandon, Mullane, Kathleen M., Frank, Ian, Denhan, Douglas, Kerwin, Edward, Zhao, Xiaoping, Ding, Baoyu, Deng, Weiping, Tomassini, Joanne E., Zhou, Honghong, Leav, Brett, Schödel, Florian

“…The mRNA-1273 vaccine for coronavirus disease 2019 (COVID-19) demonstrated 93.2% efficacy in reduction of symptomatic severe acute respiratory syndrome…”
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Long term safety and efficacy of glycopyrrolate/formoterol metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with chronic obstructive pulmonary disease by Hanania, Nicola A, Tashkin, Donald P, Kerwin, Edward M, Donohue, James F, Denenberg, Michael, O'Donnell, Denis E, Quinn, Dean, Siddiqui, Shahid, Orevillo, Chad, Maes, Andrea, Reisner, Colin

“…Abstract Background The long-term safety and efficacy of a novel Co-Suspension™ Delivery Technology glycopyrrolate (GP)/formoterol fumarate (FF) 18/9.6 μg…”
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Dose-Ranging and Cumulative Dose Studies of Albuterol Sulfate MDI in Co-Suspension Delivery™ Technology (AS MDI; PT007) in Patients with Asthma: the ASPEN and ANTORA Trials by Cappelletti, Christy, Maes, Andrea, Rossman, Kimberly, Gillen, Michael, LaForce, Craig, Kerwin, Edward M., Reisner, Colin

“…Background and Objectives Co-suspension Delivery™ Technology has been developed for the administration of albuterol sulfate pressurised inhalation suspension…”
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Indacaterol once-daily provides superior efficacy to salmeterol twice-daily in COPD: A 12-week study by Korn, Stephanie, Kerwin, Edward, Atis, Sibel, Amos, Carolynn, Owen, Roger, Lassen, Cheryl

“…Summary Background Indacaterol is a novel, inhaled once-daily ultra-long-acting β2 -agonist for the treatment of COPD. Methods This 12-week randomised,…”
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Pharmacokinetics of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler formulated using co-suspension delivery technology after single and chronic dosing in patients with COPD by Dunn, Leonard J., Kerwin, Edward M., DeAngelis, Kiernan, Darken, Patrick, Gillen, Michael, Dorinsky, Paul

“…Budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler (BGF MDI), formulated using co-suspension delivery technology, is a triple fixed-dose…”
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Efficacy of umeclidinium/vilanterol according to the degree of reversibility of airflow limitation at screening: a post hoc analysis of the EMAX trial by Vogelmeier, Claus F, Jones, Paul W, Kerwin, Edward M, Boucot, Isabelle H, Maltais, François, Tombs, Lee, Compton, Chris, Lipson, David A, Bjermer, Leif H

“…In patients with chronic obstructive pulmonary disease (COPD), the relationship between short-term bronchodilator reversibility and longer-term response to…”
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A 28-day, randomized, double-blind, placebo-controlled, parallel group study of nebulized revefenacin in patients with chronic obstructive pulmonary disease by Pudi, Krishna K, Barnes, Chris N, Moran, Edmund J, Haumann, Brett, Kerwin, Edward

“…Revefenacin is a once-daily long-acting muscarinic antagonist (LAMA) in clinical development for the treatment of patients with chronic obstructive pulmonary…”
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Efficacy and safety of a 12-week treatment with twice-daily aclidinium bromide in COPD patients (ACCORD COPD I) by Kerwin, Edward M, D'Urzo, Anthony D, Gelb, Arthur F, Lakkis, Hassan, Garcia Gil, Esther, Caracta, Cynthia F

“…This Phase III study evaluated the efficacy and safety of twice-daily aclidinium 200 μg and 400 μg versus placebo in the treatment of moderate-to-severe COPD…”
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Improvement Of Lung Function As Early As Day 1 With Beclomethasone Dipropionate Breath-Actuated Inhaler In Patients With Persistent Asthma by Kerwin, Edward M., Hickey, Lisa, Small, Calvin J., Carr, Warner W.

“…Post-hoc analysis was conducted to evaluate improvement of lung function with beclomethasone dipropionate (BDP) via a new, breath-actuated inhaler (BAI, QVAR®…”
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