Search Results - "KERSCHENSTEINER, M"

Neuro-immune crosstalk in CNS diseases by Kerschensteiner, M, Meinl, E, Hohlfeld, R

“…Abstract Immune cells infiltrate the CNS in many neurological diseases with a primary or secondary inflammatory component. In the CNS, immune cells employ…”
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TSPO PET with [18F]GE-180 sensitively detects focal neuroinflammation in patients with relapsing–remitting multiple sclerosis by Unterrainer, Marcus, Mahler, C., Vomacka, L., Lindner, S., Havla, J., Brendel, M., Böning, G., Ertl-Wagner, B., Kümpfel, T., Milenkovic, V. M., Rupprecht, R., Kerschensteiner, M., Bartenstein, P., Albert, Nathalie L.

“…Purpose Expression of the translocator protein (TSPO) is upregulated in activated macrophages/microglia and is considered to be a marker of neuroinflammation…”
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Neuroprotective approaches in the animal model by Kerschensteiner, M

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The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis by Hohlfeld, R, Kerschensteiner, M, Stadelmann, C, Lassmann, H, Wekerle, H

“…Autoreactive T cells are a regular component of the healthy immune system. It has been proposed that some of these autoreactive T cells even might have a…”
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Mechanisms of action of Methylthioadenosine: pathways implicated in neuroprotection in models of Multiple Sclerosis and other neurological diseases by Moreno, B, Di Penta, A, Kerschensteiner, M, Matute, C, Ceña, V, Lopez, I, Alberch, J, Parent, J, Serra, J, Errea, O, Villoslada, P

“…From: 5th European Workshop on Immune-Mediated Inflammatory Diseases Sitges-Barcelona, Spain 1-3 December 2010 Author details 1-Dept. of Neuroscience, Institut…”
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Neurotrophic factors protect myelin from attack by Kerschensteiner, M, Hohlfeld, R

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The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats by Bareyre, Florence M, Kerschensteiner, Martin, Raineteau, Olivier, Mettenleiter, Thomas C, Weinmann, Oliver, Schwab, Martin E

“…In contrast to peripheral nerves, central axons do not regenerate. Partial injuries to the spinal cord, however, are followed by functional recovery. We…”
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Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases by Kerschensteiner, Martin, Stadelmann, Christine, Dechant, Georg, Wekerle, Hartmut, Hohlfeld, Reinhard

“…Inflammatory reactions in the central nervous system usually are considered detrimental, but recent evidence suggests that they also can be beneficial and even…”
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Dual role of inflammation in CNS disease by BIRNBAUM, Gary, LEIST, Thomas P, LUBLIN, Fred D, HOHLFELD, Reinhard, KERSCHENSTEINER, Martin, MEINL, Edgar

“…Inflammatory responses in the CNS have usually been perceived to cause or contribute to neuron injury. However, emerging evidence suggests that inflammatory…”
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Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury by Sanes, Joshua R, Bareyre, Florence M, Kerschensteiner, Martin, Misgeld, Thomas

“…The rodent corticospinal tract (CST) has been used extensively to investigate regeneration and remodeling of central axons after injury. CST axons are…”
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BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells? by STADELMANN, Christine, KERSCHENSTEINER, Martin, MISGELD, Thomas, BRÜCK, Wolfgang, HOHLFELD, Reinhard, LASSMANN, Hans

“…Recent immunohistological and imaging studies emphasize the crucial role of axonal injury in determining the extent of permanent neurological deficits in…”
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Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? by Kerschensteiner, M, Gallmeier, E, Behrens, L, Leal, V V, Misgeld, T, Klinkert, W E, Kolbeck, R, Hoppe, E, Oropeza-Wekerle, R L, Bartke, I, Stadelmann, C, Lassmann, H, Wekerle, H, Hohlfeld, R

“…Brain-derived neurotrophic factor (BDNF) has potent effects on neuronal survival and plasticity during development and after injury. In the nervous system,…”
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The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis by Hohlfeld, Reinhard, Kerschensteiner, Martin, Stadelmann, Christine, Lassmann, Hans, Wekerle, Hartmut

“…Autoreactive T cells are a component of the normal immune system. It has been proposed that some of these autoreactive T cells even have a protective function…”
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NEURO-IMMUNE CROSSTALK IN CNS DISEASES : Brain-Immune Interactions in Acute and Chronic Brain Disorders by KERSCHENSTEINER, M, MEINL, E, HOHLFELD, R

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In vivo imaging of axonal degeneration and regeneration in the injured spinal cord by Misgeld, Thomas, Kerschensteiner, Martin, Schwab, Martin E, Lichtman, Jeff W

“…The poor response of central axons to transection underlies the bleak prognosis following spinal cord injury. Here, we monitor individual fluorescent axons in…”
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Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis : Current status and recommendations in Germany by Bittner, Stefan, Engel, Sinah, Lange, Christoph, Weber, Martin S, Haghikia, Aiden, Luessi, Felix, Korn, Thomas, Klotz, Luisa, Bayas, Antonios, Paul, Friedemann, Heesen, Christoph, Stangel, Martin, Wildemann, Brigitte, Bergh, Florian Then, Tackenberg, Björn, Trebst, Corinna, Warnke, Clemens, Linker, Ralf, Kerschensteiner, Martin, Zettl, Uwe, Tumani, Hayrettin, Brück, Wolfgang, Meuth, Sven G, Kümpfel, Tanja, Hemmer, Bernhard, Wiendl, Heinz, Gold, Ralf, Zipp, Frauke

“…After years of low incidence, a large increase of new tuberculosis (TB) cases has been reported in Germany since 2015. New immunotherapies for the treatment of…”
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Remodeling of axonal connections contributes to recovery in an animal model of multiple sclerosis by Kerschensteiner, Martin, Bareyre, Florence M, Buddeberg, Bigna S, Merkler, Doron, Stadelmann, Christine, Brück, Wolfgang, Misgeld, Thomas, Schwab, Martin E

“…In multiple sclerosis (MS), inflammation in the central nervous system (CNS) leads to damage of axons and myelin. Early during the clinical course, patients…”
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Targeting Experimental Autoimmune Encephalomyelitis Lesions to a Predetermined Axonal Tract System Allows for Refined Behavioral Testing in an Animal Model of Multiple Sclerosis by Kerschensteiner, Martin, Stadelmann, Christine, Buddeberg, Bigna S., Merkler, Doron, Bareyre, Florence M., Anthony, Daniel C., Linington, Christopher, Brück, Wolfgang, Schwab, Martin E.

“…In multiple sclerosis (MS) the structural damage to axons determines the persistent clinical deficit patients acquire during the course of the disease. It is…”
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Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology by Storch, Maria K., Stefferl, Andreas, Brehm, Uschi, Weissert, Robert, Wallström, Erik, Kerschensteiner, Martin, Olsson, Tomas, Linington, Chris, Lassmann, Hans

“…Multiple sclerosis is a chronic inflammatory disease characterized by perivenous inflammation and focal destruction of myelin. Many attempts have been…”
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The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis by Hohlfeld, R, Kerschensteiner, M, Stadelmann, C, Lassmann, H, Wekerle, H

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